RAGE Antibody, CT | EMD Millipore AB5601 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RAGE Antibody, CT

catalog :

AB5601

quantity :

200 µL

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

application :

immunohistochemistry

citations: 1

Reference
Foster D, Spruill L, Walter K, Nogueira L, Fedarovich H, Turner R, et al. AGE metabolites: a biomarker linked to cancer disparity?. Cancer Epidemiol Biomarkers Prev. 2014;23:2186-91 pubmed publisher

product information

Catalog Number :

AB5601

Subcategory :

Neuroscience

Product Name :

Anti-RAGE Antibody, CT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9UQ07

Host Name :

Goat

Antigen :

RAGE

Conjugate :

Serum

Product Description :

Anti-RAGE Antibody, CT

Cross Reactivity :

Human

Background :

RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

Immunogen :

Synthetic peptide from the C-terminus of human RAGE, amino acids 385 to 399. {RAELNQSEEPEAGES}.

Specificity :

Specific for Receptor of Advanced Glycosylated End Products (RAGE). This antibody immunolabels vessels from diabetic tissues in formalin-fixed paraffin sections.

Package Size :

200 µL

Uses :

ELISA;Immunohistochemistry

Storage :

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.