Interleukin 27 (IL-27) Antibody | EMD Millipore 06-1082 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Interleukin 27 (IL-27) Antibody

catalog :

06-1082

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, chimpanzee

application :

western blot, flow cytometry

product information

Catalog Number :

06-1082

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Interleukin 27 (IL-27) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8NEV9

Host Name :

Rabbit

Antigen :

Interleukin 27 (IL-27)

Conjugate :

Affinity Purified

Product Description :

Anti-Interleukin 27 (IL-27) Antibody

Cross Reactivity :

Human;Chimpanzee

Background :

Interleukin 27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits: Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-27A). IL-27 has pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. IL-27 is secreted by antigen-presenting cells and plays an important function in regulating the activity of B and T lymphocytes. IL-27 suppresses the expression of GATA3, the inhibitor TH1 cells development. In addition to suppressing cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication (Uniprot/Swissprot).

ALT Names :

Interleukin-27 subunit alpha;IL-27 subunit alpha

Immunogen :

KLH-conjugated linear peptide corresponding to the mature chain of Interleukin 27 (IL-27), subunit alpha.

Specificity :

This antibody recognizes the mature chain of interleukin 27 (IL-27), subunit alpha. In endogenous lysates, antibody may detect the heterodimeric IL-27, composed of both IL-27 subunit alpha and beta.

Package Size :

100 μg

Uses :

Western Blotting;Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt