Nibrin/NBS1 Antibody, clone Y112, rabbit monoclonal | EMD Millipore 04-236 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Nibrin/NBS1 Antibody, clone Y112, rabbit monoclonal

catalog :

04-236

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y112

The same clone is also sold as:

Abcam: ab32074

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; fig s1	Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed publisher
western blot; mouse; fig 6	Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed publisher

product information

Catalog Number :

04-236

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Nibrin/NBS1 Antibody, clone Y112, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O60934

Host Name :

Rabbit

Antigen :

Nibrin/NBS1

Clone :

Y112

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-Nibrin/NBS1 Antibody, clone Y112, rabbit monoclonal

Cross Reactivity :

Human;Mouse

Background :

Nibrin (NBS1, NBN) is known to be a key regulator of DNA Damage repair by forming a complex with Rad50 and MRE11. This complex, more commonly referred to as MRN (Mre11/Rad50/Nibrin) is important in double-stranded break repair, DNA recombination, cell cycle checkpoint control, and meiosis. This complex quickly recognizes double stranded break (DSB) sites and quickly relocates to these sites. Nibrin senses DNA damage by recruiting ATM, ATR, and DNA-PK to the damage sites and activation their functions.

ALT Names :

Cell cycle regulatory protein p95;Nijmegen breakage syndrome 1 (nibrin) ;Nijmegen breakage syndrome protein 1;p95 protein of the MRE11/RAD50 complex

Immunogen :

KLH conjugated to Nibrin/NBS1 linear peptide.

Specificity :

This antibody recognizes Nibrin/NBS1.

Package Size :

100 μL

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.