CDK9 (Thr186) Polyclonal Antibody | Bioss bs-3097R product information

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product summary

company name :

Bioss

product type :

antibody

product name :

CDK9 (Thr186) Polyclonal Antibody

catalog :

bs-3097R

quantity :

100 ul

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

bs-3097R

Product Name :

CDK9 (Thr186) Polyclonal Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

Thr186

Product Type :

Primary Antibody

Size :

100 ul

List Price :

289 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement.

ALTnames :

TAK; C-2k; CTK1; CDC2L4; PITALRE; Cyclin-dependent kinase 9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; CDK9

Epitope :

KLH conjugated synthetic phosphopeptide derived from human CDK9 around the phosphorylation site of Thr186

Purity :

Purified by Protein A.

Concentration :

1ug/ul

Storage :

Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

Uses :

WB, IHC-P, IF(IHC-P)

Application Summary :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)