GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody | Bioss bs-2073R product information

product summary

company name :

Bioss

product type :

antibody

product name :

GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody

catalog :

bs-2073R

quantity :

100 ul

price :

309.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse western blot; mouse	Zhao H, Di J, Liu W, Liu H, Lai H, Lu Y. Involvement of GSK3 and PP2A in ginsenoside Rb1's attenuation of aluminum-induced tau hyperphosphorylation. Behav Brain Res. 2013;241:228-34 pubmed publisher

product information

sku :

bs-2073R

name :

GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

GSK3 Alpha/Beta Tyr279+Tyr216

modification :

Phosphorylation

modification site :

Tyr279+Tyr216

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

250-300/483

subcellular locations :

Nucleus, Cell membrane

source :

KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha/Beta around the phosphorylation site of Tyr279/Tyr216

gene id link :

Entrez Gene: 29,312,932

swiss prot :

P49840

swiss prot link :

Swiss Prot: P49840

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

309.5 USD

background :

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3A

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage