LAMP-1 Polyclonal Antibody | Bioss bs-1970R product information

product summary

company name :

Bioss

product type :

antibody

product name :

LAMP-1 Polyclonal Antibody

catalog :

bs-1970R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

primates, human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Bechor S, Nachmias D, Elia N, Haim Y, Vatarescu M, Leikin Frenkel A, et al. Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:1001-1012 pubmed publisher
western blot; mouse	Guo H, Zhao M, Qiu X, Deis J, Huang H, Tang Q, et al. Niemann-Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes. J Lipid Res. 2016;57:1644-58 pubmed publisher
western blot; mouse	Jeong K, Lee E, Yang S, Seong J. Combination of macrophage inflammatory protein 1 alpha with existing therapies to enhance the antitumor effects on murine hepatoma. J Radiat Res. 2015;56:37-45 pubmed publisher
immunocytochemistry; primates	Sun M, Huang L, Wang R, Yu Y, Li C, Li P, et al. Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication. Autophagy. 2012;8:1434-47 pubmed publisher
	Goreczny G, Forsythe I, Turner C. Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1. Oncogene. 2018;37:1699-1713 pubmed publisher

product information

sku :

bs-1970R

name :

LAMP-1 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

LAMP-1

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

300-350/417

subcellular locations :

Lumenal, Lysosome

source :

KLH conjugated synthetic peptide derived from human LAMP-1

gene id link :

Entrez Gene: 3916

swiss prot :

P11279

swiss prot link :

Swiss Prot: P11279

applications :

WB, FCM, IHC-P, IF(IHC-P), IF(ICC)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

LAMPA; CD17a; LGP12; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD17 antigen-like family member A; LAMP1

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage