DOG1 (Discovered on GIST 1) | BioLogo DOG001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

DOG1 (Discovered on GIST 1)

catalog :

DOG001

quantity :

1 ml

price :

360 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DOG1.1

application :

immunohistochemistry

product information

Catalog Number :

DOG001

Product Name :

DOG1 (Discovered on GIST 1)

Host Species :

Mouse

Product Type :

Primary Antibody

Size :

1 ml

List Price :

360 USD

Clone :

DOG1.1

Isotype :

IgG

CrossReactivity :

Human, chicken, hamster, rat

Background :

DOG1 (Discovered on GIST 1) Gen encodes a cell surface protein of unknown function, which is exprimed especially in gastrointestinal stromal tumours (GIST). The expression in GIST is independent of the expression of c-kit and PDGFR-alpha mutations. For this reason DOG1 antibody can detect a higher percentage of GIST (87%) than traditionally used markers like CD117 (c-kit)(74%) and CD34, which are used for the differential diagnoses of gastrointestinal stromal tumours (Espinosa et al., 2008). DOG1 immunoreactivity was 79% in GIST with PDGFRa mutations, while only 9% of these were CD117-positive. Therefore the diagnosis with DOG1 could also influence the therapy with Imatinib (Glivec®) a tyrosinkinase inhibitor, which is used for the treatment of CML and GIST.

Immunogen :

QKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL .
MSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQ
QLLETCMEKER
Synthetic peptide (FLJ34272) human DOG1 sequence:

Specificity :

Human DOG1, gastrointestinal stromal tumours (GIST)

Concentration :

50 µg/ml

Application Summary :

IHC(C, P)

Storage :

2-8°C

General References :

1. West R.B., et al. (2004) The novel marker , DOG1, is expressed ubiquitously in gastrointestinal stromal tumours irrespective of KIT or PDGFRA mutation. Am J. Pathol. 165(1) 107-113.

Product References :

2. Espinosa I., et al.(2008) A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumours. Am J. Surg. Pathol 32(2)210-218