American Research Products

protein

IL-17E/IL-25

19-C092

10 ug

119.00 USD

19-C092

IL-17E/IL-25

Recombinant Protein

10 ug

119.00 USD

The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25(IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR,and the cross-linking induces NF-kappaB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells. Human IL-17E cDNA encodes a 177 amino acid residues (aa) precursor protein with a putative 32 aa signal peptide. A second isoform of human IL-17E encoding a 161 aa precursor protein also exists.

Greater than 95% as determined by reducing SDS-PAGE.

Recombinant Human IL-17E was lyophilized at 1mg/ml in 20mM PBS.