This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Agrisera
product type :
antibody
product name :
F12 Coagulation factor XII
catalog :
IMS01-137-306
quantity :
100 µl (15.1 mg/ml)
price :
348 USD
clonality :
polyclonal
host :
chicken
conjugate :
nonconjugated
reactivity :
human
product information
Product number :
IMS01-137-306
Product name :
F12 Coagulation factor XII
Quantity :
100 µl (15.1 mg/ml)
List Price :
348 USD
Immunogen :
Purified full length native protein UnniProt:P00748
Host :
Chicken
Clonality :
Polyclonal
Purity :
Purified, total IgY (chicken egg yolk immunoglobulin) in 0.9% NaCl, 0.02% sodium azide.
Format :
Liquid
Recommended dilutions :
1: 10 000 (ELISA)
Expected apparent MW :
67 kDa
Confirmed reactivity :
Human
Predicted reactivity :
Human
Not reactive in :
No confirmed exceptions from predicted reactivity are currently known.
Additional information :
Detects human coagulation factor XII and XIIa
Related products :
Secondary antibodies
Background :
Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any apparent clinical symptoms and the sole effect is that whole blood clotting time is prolonged.
Storage :
Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
UniProt number :
P00748
Commodity Code :
38220000
Our Category :
Immunology
Research area :
Immunology
company information
Agrisera
Agrisera is a Swedish company specializing in polyclonal and monoclonal antibody production, offering primary and secondary antibodies off-the-shelf. Agrisera offers an extensive list of antibodies suitable for detection of plant and algal proteins in a wide range of research areas and applications. They are reactive in thousands of plant and algal species and cited in thousands of scientific articles. Agrisera was awarded as the Plant Science Antibody Supplier of the Year by CiteAB for the company with the most antibody citations for research related to plant science during 2018.
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