This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3.1-p300
catalog :
23252
citations: 36
Reference
Shin D, Jo J, Choi M, Kim K, Bae Y, Kim S. Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer. Exp Mol Med. 2023;55:2220-2237 pubmed publisher
Yu D, Liang Y, Kim C, Jaganathan A, Ji D, Han X, et al. Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma. Nat Commun. 2023;14:378 pubmed publisher
Portuguez A, Grbesa I, Tal M, Deitch R, Raz D, Kliker L, et al. Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression. Nucleic Acids Res. 2022;: pubmed publisher
Kolling L, Tatti R, Lowry T, Loeven A, Fadool J, Fadool D. Modulating the excitability of olfactory output neurons affects whole-body metabolism. J Neurosci. 2022;: pubmed publisher
Li W, Wang Y, Zhu L, DU S, Mao J, Wang Y, et al. The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. J Cell Mol Med. 2021;25:6709-6720 pubmed publisher
Chang C, Liu Y, Lin C, Liao Y. Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells. Biochem Biophys Res Commun. 2021;534:53-58 pubmed publisher
Schwartz A, Kapur A, Huang Z, Anangi R, Spear J, Stagg S, et al. Olfactory bulb-targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice. J Neurochem. 2020;: pubmed publisher
Son S, Park S, Stamatakou E, Vicinanza M, Menzies F, Rubinsztein D. Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Nat Commun. 2020;11:3148 pubmed publisher
Cheng Q, Shang Y, Huang W, Zhang Q, Li X, Zhou Q. p300 mediates the histone acetylation of ORMDL3 to affect airway inflammation and remodeling in asthma. Int Immunopharmacol. 2019;76:105885 pubmed publisher
Mahmud Z, Gomes A, Lee H, Aimjongjun S, Jiramongkol Y, YAO S, et al. EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer. Cancers (Basel). 2019;11: pubmed publisher
Li J, Aponte Paris S, Thakur H, Kapiloff M, Dodge Kafka K. Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. J Biol Chem. 2019;294:2543-2554 pubmed publisher
Mirza A, McKellar S, Urman N, Brown A, Hollmig T, Aasi S, et al. LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Cell. 2019;176:198-212.e15 pubmed publisher
Wu T, Kamikawa Y, Donohoe M. Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1. Cell Rep. 2018;25:1756-1771 pubmed publisher
Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher
Sacta M, Tharmalingam B, Coppo M, Rollins D, Deochand D, Benjamin B, et al. Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages. elife. 2018;7: pubmed publisher
Duex J, Swain K, Dancik G, Paucek R, Owens C, Churchill M, et al. Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. Mol Cancer Res. 2018;16:69-77 pubmed publisher
Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res. 2017;77:4342-4354 pubmed publisher
Boudreau H, Ma W, Korzeniowska A, Park J, Bhagwat M, Leto T. Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53. Oncotarget. 2017;8:44379-44397 pubmed publisher
Yan L, Wang Y, Liu J, Nie Y, Zhong X, Kan Q, et al. Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin. Mol Pharmacol. 2017;92:113-123 pubmed publisher
Ma Z, Chalkley R, Vosseller K. Hyper-O-GlcNAcylation activates nuclear factor ?-light-chain-enhancer of activated B cells (NF-?B) signaling through interplay with phosphorylation and acetylation. J Biol Chem. 2017;292:9150-9163 pubmed publisher
Sato Y, Tsuyama T, Sato C, Karim M, Yoshizawa T, Inoue M, et al. Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase. J Biol Chem. 2017;292:8716-8728 pubmed publisher
Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin M, Singh P, et al. Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. Breast Cancer Res Treat. 2017;163:461-474 pubmed publisher
Ding L, Yang M, Zhao T, Lv G. Roles of p300 and cyclic adenosine monophosphate response element binding protein in high glucose-induced hypoxia-inducible factor 1α inactivation under hypoxic conditions. J Diabetes Investig. 2017;8:277-285 pubmed publisher
Andrews P, Kao K. Wnt/?-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members. Biochem J. 2016;473:4193-4203 pubmed
Piekna Przybylska D, Bambara R, Balakrishnan L. Acetylation regulates DNA repair mechanisms in human cells. Cell Cycle. 2016;15:1506-17 pubmed publisher
Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski M, Biswas A, et al. Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Biochim Biophys Acta. 2016;1859:1155-1169 pubmed publisher
Park J, Kim T, Jo S, Kim M, Ahn Y. Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity. Sci Rep. 2015;5:17395 pubmed publisher
Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, et al. Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Cancer Discov. 2016;6:430-45 pubmed publisher
Hilton I, D Ippolito A, Vockley C, Thakore P, Crawford G, Reddy T, et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol. 2015;33:510-7 pubmed publisher
Xiao Y, Nagai Y, Deng G, Ohtani T, Zhu Z, Zhou Z, et al. Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep. 2014;7:1471-1480 pubmed publisher
Kim S, Lim J, Woo C. ERK5 inhibition ameliorates pulmonary fibrosis via regulating Smad3 acetylation. Am J Pathol. 2013;183:1758-1768 pubmed publisher
Chen W, Jia W, Wang K, Si X, Zhu S, Duan T, et al. Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells. PLoS ONE. 2013;8:e66076 pubmed publisher
Gao B, Xu W, Zhong L, Zhang Q, Su Y, Xiong S. p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity. Eur J Immunol. 2013;43:2174-84 pubmed publisher
Fatoba S, Tognetti S, Berto M, Leo E, Mulvey C, Godovac Zimmermann J, et al. Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation. Nucleic Acids Res. 2013;41:4065-79 pubmed publisher
Wu L, Ma C, Zhao Y, Jain A. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem. 2011;286:2236-44 pubmed publisher
Chen L, Mu Y, Greene W. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 2002;21:6539-48 pubmed
product information
Catalog Number :
23252
Product Name :
pcDNA3.1-p300
article :
doi10.1093/emboj/cdf660
id3110
pubmed_id12456660
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1 (-)
backbone_mutation
backbone_originInvitrogen
backbone_size5428
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3HindIII
cloning_site_5NotI
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesKAT3B, MKHK2, RSTS2, p300
geneEP300
id2033
genbank_ids
mutation
namep300
shRNA_sequence
size7245
species
9606
Homo sapiens
tags
locationC terminal on insert
tag6xHis
resistance markers :
176
tags :
Unknown
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA