This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Cdk2-HA
catalog :
1884
citations: 10
Reference
Kelly R, Huehls A, Venkatachalam A, Huntoon C, Machida Y, Karnitz L. Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress. J Biol Chem. 2022;298:101777 pubmed publisher
Xia P, Chen J, Liu Y, Fletcher M, Jensen B, Cheng Z. Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. J Biol Chem. 2020;295:4265-4276 pubmed publisher
Xia P, Liu Y, Chen J, Coates S, Liu D, Cheng Z. Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy. J Biol Chem. 2018;293:19672-19685 pubmed publisher
UmaƱa A, Iwahori S, Kalejta R. Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk). ACS Chem Biol. 2018;13:189-199 pubmed publisher
Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher
Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S. NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell. 2017;65:801-817.e4 pubmed publisher
Mazzolini L, Broban A, Froment C, Burlet Schiltz O, Besson A, Manenti S, et al. Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry. Cell Cycle. 2016;15:2742-52 pubmed publisher
Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
Vacher H, Yang J, Cerda O, Autillo Touati A, Dargent B, Trimmer J. Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting. J Cell Biol. 2011;192:813-24 pubmed publisher
van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science. 1993;262:2050-4 pubmed
product information
Catalog Number :
1884
Product Name :
Cdk2-HA
article :
doi10.1126/science.8266103
id114
pubmed_id8266103
bacterial resistance :
Ampicillin
cloning :
backbonepCMV-neo-Bam
backbone_mutation
backbone_originVogelstein lab (Addgene plasmid# 16440)
backbone_size6550
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
See scanned map.
origin :
37
pi :
alt_names
cyclin-dependent kinase 2
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5BamHI
promoterCMV
sequencing_primer_3Bglob-pA-R
sequencing_primer_5Bglob-intron-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCDKN2, p33(CDK2)
geneCDK2
id1017
genbank_ids
mutation
nameCdk2
shRNA_sequence
size900
species
9606
Homo sapiens
tags
locationC terminal on insert
tagHA
resistance markers :
544
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA