Geminin antibody (pAb) | Active Motif 61135 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Geminin antibody (pAb)

catalog :

61135

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

product information

Catalog Number :

61135

Product Name :

Geminin antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

Serum

CrossReactivity :

Human

Background :

Geminin is a crucial cell cycle regulatory protein that controls DNA replication and centrosome function. Geminin inhibits DNA replication by preventing the binding of the MCM complex into the pre-replication complex. Geminin accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition. Geminin functions as a homotetramer and interacts with DNA replication licensing factor CDT1. The interaction between Geminin and CDT1 is crucial to restrict DNA replication to once per cell cycle. Geminin is required for the formation of pluripotent cells in the developing embryo and essential for pluripotency in the embryonic stem cells. In ESCs, Geminin remains during G1 and sustains core pluripotency factors (Oct4, Sox2, and Nanog) by antagonizing the action of the chromatin remodeling protein BRG1.

Immunogen :

This Geminin antibody was raised against full-length recombinant human Geminin protein.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: IP: Wohlschlegel J et al. (2000) Science 290: 2309-2312.WB: Wohlschlegel J et al. (2000) Science 290: 2309-2312.