This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Ascent Scientific
product type :
antibody
product name :
Giantin antibody
catalog :
ab24586
quantity :
100 ul
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 60
Published Application/Species/DilutionReference
  • immunocytochemistry; human; 1:250
Siupka P, Hamming O, Kang L, Gad H, Hartmann R. A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane. Genes Immun. 2015;16:405-13 pubmed publisher
  • western blot; human; fig 1
  • immunocytochemistry; human; fig 1
Isogai T, van der Kammen R, Innocenti M. SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep. 2015;5:9802 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig s15a
Jewell J, Kim Y, Russell R, Yu F, Park H, Plouffe S, et al. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015;347:194-8 pubmed publisher
  • immunocytochemistry; human
Ramakrishnan R, Tyurin V, Tuyrin V, Veglia F, Condamine T, Amoscato A, et al. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol. 2014;192:2920-31 pubmed publisher
  • immunohistochemistry; human
Liaunardy-Jopeace A, Bryant C, Gay N. The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. Sci Signal. 2014;7:ra70 pubmed publisher
  • immunocytochemistry; human; 1:1000
Zouk H, d'Hennezel E, Du X, Ounissi-Benkalha H, Piccirillo C, Polychronakos C. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. Clin Exp Immunol. 2014;175:485-97 pubmed publisher
  • immunocytochemistry; human; 1:500
Dolega M, Wagh J, Gerbaud S, Kermarrec F, Alcaraz J, Martin D, et al. Facile bench-top fabrication of enclosed circular microchannels provides 3D confined structure for growth of prostate epithelial cells. PLoS ONE. 2014;9:e99416 pubmed publisher
  • immunocytochemistry; human; 1:500
Mousnier A, Schroeder G, Stoneham C, So E, Garnett J, Yu L, et al. A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases. MBio. 2014;5: pubmed publisher
  • immunohistochemistry - frozen section; human
Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin U, et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014;23:4621-38 pubmed publisher
  • immunocytochemistry; human
  • immunocytochemistry; mouse
Oliveira C, Querido B, Sluijter M, de Groot A, van der Zee R, Rabelink M, et al. New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation. J Immunol. 2013;191:4020-8 pubmed publisher
  • immunocytochemistry; human; 1 ug/ml
Dupuis N, Lebon S, Kumar M, Drunat S, Graul-Neumann L, Gressens P, et al. A novel RAB33B mutation in Smith-McCort dysplasia. Hum Mutat. 2013;34:283-6 pubmed publisher
  • immunocytochemistry; human; 1:1000
Körschen H, Yildiz Y, Raju D, Schonauer S, Bönigk W, Jansen V, et al. The non-lysosomal β-glucosidase GBA2 is a non-integral membrane-associated protein at the endoplasmic reticulum (ER) and Golgi. J Biol Chem. 2013;288:3381-93 pubmed publisher
Nonnenmacher M, Cintrat J, Gillet D, Weber T. Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction. J Virol. 2015;89:1673-87 pubmed publisher
Gee H, Kim J, Lee M. Analysis of conventional and unconventional trafficking of CFTR and other membrane proteins. Methods Mol Biol. 2015;1270:137-54 pubmed publisher
Petrosyan A, Ali M, Cheng P. Keratin 1 plays a critical role in golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail. J Biol Chem. 2015;290:6256-69 pubmed publisher
Petrosyan A, Holzapfel M, Muirhead D, Cheng P. Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis. Mol Cancer Res. 2014;12:1704-16 pubmed publisher
Rudell J, Borges L, Rudell J, Beck K, Ferns M. Determinants in the β and δ subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor. J Biol Chem. 2014;289:203-14 pubmed publisher
Koreishi M, Gniadek T, Yu S, Masuda J, Honjo Y, Satoh A. The golgin tether giantin regulates the secretory pathway by controlling stack organization within Golgi apparatus. PLoS ONE. 2013;8:e59821 pubmed publisher
Hajdin K, D'Alessandro V, Niggli F, Schafer B, Bernasconi M. Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model. PLoS ONE. 2010;5:e10445 pubmed publisher
Boassa D, Solan J, Papas A, Thornton P, Lampe P, Sosinsky G. Trafficking and recycling of the connexin43 gap junction protein during mitosis. Traffic. 2010;11:1471-86 pubmed publisher
Rismanchi N, Puertollano R, Blackstone C. STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Traffic. 2009;10:201-17 pubmed publisher
Leonhardt R, Vigneron N, Rahner C, van den Eynde B, Cresswell P. Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction. J Biol Chem. 2010;285:16166-83 pubmed publisher
Lee J, Reich R, Xu F, Sehgal P. Golgi, trafficking, and mitosis dysfunctions in pulmonary arterial endothelial cells exposed to monocrotaline pyrrole and NO scavenging. Am J Physiol Lung Cell Mol Physiol. 2009;297:L715-28 pubmed publisher
Raykhel I, Alanen H, Salo K, Jurvansuu J, Nguyen V, Latva-Ranta M, et al. A molecular specificity code for the three mammalian KDEL receptors. J Cell Biol. 2007;179:1193-204 pubmed
Grimsey N, Han G, O'Hara L, Rochford J, Carman G, Siniossoglou S. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. J Biol Chem. 2008;283:29166-74 pubmed publisher
Dron M, Dandoy-Dron F, Farooq Salamat M, Laude H. Proteasome inhibitors promote the sequestration of PrPSc into aggresomes within the cytosol of prion-infected CAD neuronal cells. J Gen Virol. 2009;90:2050-60 pubmed publisher
Bacac M, Fusco C, Planche A, Santodomingo J, Demaurex N, Leemann-Zakaryan R, et al. Securin and separase modulate membrane traffic by affecting endosomal acidification. Traffic. 2011;12:615-26 pubmed publisher
Tucker D, Ghosh M, Ghomashchi F, Loper R, Suram S, John B, et al. Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. J Biol Chem. 2009;284:9596-611 pubmed publisher
Harhaj N, Sun S, Harhaj E. Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem. 2007;282:4185-92 pubmed
Pak Y, Glowacka W, Bruce M, Pham N, Rotin D. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J Cell Biol. 2006;175:631-45 pubmed
Ishikawa H, Ma Z, Barber G. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 2009;461:788-92 pubmed publisher
Johnson J, Li C, DiPrimio N, Weinberg M, McCown T, Samulski R. Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction. J Virol. 2010;84:8888-902 pubmed publisher
Sun Q, Ju T, Cummings R. The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum. J Biol Chem. 2011;286:11529-42 pubmed publisher
Cornell C, Kiosses W, Harkins S, Whitton J. Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I. J Virol. 2007;81:6785-97 pubmed
Lee J, Yang Y, Liang F, Gough D, Levy D, Sehgal P. Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function. Am J Physiol Cell Physiol. 2012;302:C804-20 pubmed publisher
Lee J, Patel K, Almodovar S, Tuder R, Flores S, Sehgal P. Dependence of Golgi apparatus integrity on nitric oxide in vascular cells: implications in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2011;300:H1141-58 pubmed publisher
Burnett J, Zhong S, Jiang Z, Hooper A, Fisher E, McLeod R, et al. Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia. J Biol Chem. 2007;282:24270-83 pubmed
Kanda A, Chen W, Othman M, Branham K, Brooks M, Khanna R, et al. A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A. 2007;104:16227-32 pubmed
Stevanin G, Santorelli F, Azzedine H, Coutinho P, Chomilier J, Denora P, et al. Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum. Nat Genet. 2007;39:366-72 pubmed
Botella-Lopez A, Cuchillo-Ibanez I, Cotrufo T, Mok S, Li Q, Barquero M, et al. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Neurobiol Dis. 2010;37:682-91 pubmed publisher
van de Loo S, Eich F, Nonis D, Auburger G, Nowock J. Ataxin-2 associates with rough endoplasmic reticulum. Exp Neurol. 2009;215:110-8 pubmed publisher
Zhou R, Yazdi A, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469:221-5 pubmed publisher
Nhek S, Ngo M, Yang X, Ng M, Field S, Asara J, et al. Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation. Mol Biol Cell. 2010;21:2327-37 pubmed publisher
Miorin L, Maiuri P, Hoenninger V, Mandl C, Marcello A. Spatial and temporal organization of tick-borne encephalitis flavivirus replicated RNA in living cells. Virology. 2008;379:64-77 pubmed publisher
Progida C, Cogli L, Piro F, De Luca A, Bakke O, Bucci C. Rab7b controls trafficking from endosomes to the TGN. J Cell Sci. 2010;123:1480-91 pubmed publisher
Kockx M, Guo D, Traini M, Gaus K, Kay J, Wimmer-Kleikamp S, et al. Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway. J Biol Chem. 2009;284:24144-54 pubmed publisher
Tani M, Hannun Y. Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem. 2007;282:10047-56 pubmed
Hanein S, Martin E, Boukhris A, Byrne P, Goizet C, Hamri A, et al. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. Am J Hum Genet. 2008;82:992-1002 pubmed publisher
Achour L, Scott M, Shirvani H, Thuret A, Bismuth G, Labbé-Jullié C, et al. CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface. Blood. 2009;113:1938-47 pubmed publisher
Alshammari M, Al-Otaibi L, Alkuraya F. Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve--Melchior--Clausen locus. J Med Genet. 2012;49:455-61 pubmed publisher
Ramonet D, Podhajska A, Stafa K, Sonnay S, Trancikova A, Tsika E, et al. PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Hum Mol Genet. 2012;21:1725-43 pubmed publisher
Orlandi F, Venanzi F, Concetti A, Yamauchi H, Tiwari S, Norton L, et al. Antibody and CD8+ T cell responses against HER2/neu required for tumor eradication after DNA immunization with a Flt-3 ligand fusion vaccine. Clin Cancer Res. 2007;13:6195-203 pubmed
Yang G, Yang M, Lim Y, Lu J, Wang T, Qi J, et al. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J Neurochem. 2012;122:1010-22 pubmed publisher
Evans R, Schwarz N, Nagel-Wolfrum K, Wolfrum U, Hardcastle A, Cheetham M. The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Hum Mol Genet. 2010;19:1358-67 pubmed publisher
Jovic M, Kieken F, Naslavsky N, Sorgen P, Caplan S. Eps15 homology domain 1-associated tubules contain phosphatidylinositol-4-phosphate and phosphatidylinositol-(4,5)-bisphosphate and are required for efficient recycling. Mol Biol Cell. 2009;20:2731-43 pubmed publisher
Chan K, Zhang P, Song Z. Identification of essential amino acid residues in the hydrophilic loop regions of the CMP-sialic acid transporter and UDP-galactose transporter. Glycobiology. 2010;20:689-701 pubmed publisher
Nayak R, Sen P, Ghosh S, Gopalakrishnan R, Esmon C, Pendurthi U, et al. Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. Blood. 2009;114:1974-86 pubmed publisher
Loschi M, Leishman C, Berardone N, Boccaccio G. Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci. 2009;122:3973-82 pubmed publisher
Salamat M, Dron M, Chapuis J, Langevin C, Laude H. Prion propagation in cells expressing PrP glycosylation mutants. J Virol. 2011;85:3077-85 pubmed publisher
Madan V, Castello A, Carrasco L. Viroporins from RNA viruses induce caspase-dependent apoptosis. Cell Microbiol. 2008;10:437-51 pubmed
product information
Catalog Number :
ab24586
Product Name :
Giantin antibody
Host Species :
Rabbit
Clonality :
polyclonal
Product Type :
Primary antibodies
Size :
100 ul
SwissProtID :
Q14789
Isotype :
IgG
CrossReactivity :
Reacts with: Human, Mouse, Rat, Hamster, Monkey.
Application Summary :
ICC/IF, IHC-Fr, WB
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK