This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Ascent Scientific
product type :
antibody
product name :
DNA PKcs antibody [18-2]
catalog :
ab1832
quantity :
500 ul
clonality :
monoclonal
host :
mouse
clone name :
18-2
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, proximity ligation assay
citations: 20
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig 2
  • proximity ligation assay; human; fig 3
Sahlberg S, Gustafsson A, Pendekanti P, Glimelius B, Stenerlow B. The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. Tumour Biol. 2014;35:3525-34 pubmed publisher
  • western blot; human; fig 4
Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
  • immunocytochemistry; human; fig s7
Saquilabon Cruz G, Kong X, Silva B, Khatibzadeh N, Thai R, Berns M, et al. Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res. 2016;44:e27 pubmed publisher
  • immunohistochemistry; mouse; fig 8
Quigley H, Pitha I, Welsbie D, Nguyen C, Steinhart M, Nguyen T, et al. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS ONE. 2015;10:e0141137 pubmed publisher
  • western blot; human
Zhou Y, Caron P, Legube G, Paull T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res. 2014;42:e19 pubmed publisher
  • western blot; human
Vidi P, Liu J, Salles D, Jayaraman S, Dorfman G, Gray M, et al. NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks. Nucleic Acids Res. 2014;42:6365-79 pubmed publisher
  • western blot; human; 1:5000; fig s6
Fernandez-Vidal A, Guitton-Sert L, Cadoret J, Drac M, Schwob E, Baldacci G, et al. A role for DNA polymerase θ in the timing of DNA replication. Nat Commun. 2014;5:4285 pubmed publisher
  • western blot; human
Bombarde O, Boby C, Gomez D, Frit P, Giraud-Panis M, Gilson E, et al. TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J. 2010;29:1573-84 pubmed publisher
Keka I, Mohiuddin -, Maede Y, Rahman M, Sakuma T, Honma M, et al. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic Acids Res. 2015;43:6359-72 pubmed publisher
Li W, Zhang L, Li H, Zheng S, Zhao L. WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS ONE. 2014;9:e94751 pubmed publisher
Yuan M, Eberhart C, Kai M. RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation. Oncotarget. 2014;5:2820-6 pubmed
Liccardi G, Hartley J, Hochhauser D. EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res. 2011;71:1103-14 pubmed publisher
Lossaint G, Besnard E, Fisher D, Piette J, Dulic V. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene. 2011;30:4261-74 pubmed publisher
Qi Y, Schoene N, Lartey F, Cheng W. Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells. J Biol Chem. 2010;285:33010-7 pubmed publisher
Sun L, Prince T, Manjarrez J, Scroggins B, Matts R. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012;1823:1092-101 pubmed publisher
Sanz-García M, Monsalve D, Sevilla A, Lazo P. Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem. 2012;287:23757-68 pubmed publisher
Huston E, Lynch M, Mohamed A, Collins D, Hill E, MacLeod R, et al. EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proc Natl Acad Sci U S A. 2008;105:12791-6 pubmed publisher
Bindra R, Goglia A, Jasin M, Powell S. Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res. 2013;41:e115 pubmed publisher
Baserga M, Hale M, Ke X, Wang Z, Yu X, Callaway C, et al. Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006;291:R412-8 pubmed
O'Brien E, Barnes V, Zhao L, McKnight R, Yu X, Callaway C, et al. Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. Am J Physiol Regul Integr Comp Physiol. 2007;293:R314-22 pubmed
product information
Catalog Number :
ab1832
Product Name :
DNA PKcs antibody [18-2]
Host Species :
Mouse
Clonality :
monoclonal
Product Type :
Primary antibodies
Size :
500 ul
SwissProtID :
P78527
Isotype :
IgG1
CrossReactivity :
Reacts with: Human, Mouse, Rat.
Application Summary :
Flow Cyt, FuncS, ICC/IF, IHC-Fr, IHC-P, IP, WB
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK