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product summary
company name :
ALPCO
product type :
ELISA/assay
product name :
VEGF-A ELISA (Vascular Endothelial Growth Factor-A ELISA)
catalog :
61-VGAHU-E01
quantity :
96 Wells
price :
700.00 USD
product information
Catalog Number :
61-VGAHU-E01
Product Name :
VEGF-A ELISA (Vascular Endothelial Growth Factor-A ELISA)
List Price :
700.00 USD
Description :
One of the key molecules for angiogenesis and for the survival of the endothelium is vascular endothelial growth factor (VEGF-A). It is a specific endothelial cell mitogen and a strong vascular permeability factor (VPF).  . VEGF-A is a heparin-binding glycoprotein, secreted as a homodimer of 45 kDa by many different cell types. VEGF-A also causes vasodilation through the nitiric oxide synthase pathway in endothelial cells and can activate migration in monocytes. Many different splice variants of VEGF-A have been described, but VEGF165 is the most predominant protein and anchors with its heparin binding domain to extracellular matrix and to heparin sulfate. Examples where VEGF-A plays an important role are psoriasis andrheumatoid arthritis, as well as the ovarian hyperstimulation syndrome. Diabetic retinopathy is associated with high intraocular levels of VEGF-A, and inhibition of VEGF-A function may result in infertility by blockage of corpus luteum function. Direct demonstration of the importance of VEGF-A in tumor growth has been achieved using dominant negative VEGF receptors to block in vivo proliferation, as well as blocking antibodies to VEGF or to one of the VEGF receptors. VEGF-A transcription is highly activated by hypoxia and by oncogenes like H-ras and several transmembrane tyrosine kinases, such as epidermal growth factor receptor and ErbB2. Together these pathways account for a marked upregulation of VEGF-A in tumors compared to normal tissues and are often of prognostic importance and relevance. Targeting the VEGF signalling may be of major therapeutic importance for many diseases and serves as a basis for the design of future (anti)-angiogenic treatments.
Therapeutic Areas :
Immunology
Species :
Human
Sample Types :
Cell Culture, Citrate Plasma, EDTA Plasma, Heparin Plasma, Serum
Size :
96 Wells
Regulatory Status :
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution :
Available Worldwide
Applications :
Immunoassays
Sample Size :
50 µL
Range :
15.6 - 1,000 pg/mL
Sensitivity :
7.9 pg/mL
Incubation Time :
4hr 30min
company information
ALPCO
26G Keewaydin Drive
Salem, NH 03079
email@alpco.com
http://www.alpco.com
1-603-893-8914
headquarters: USA
ALPCO was founded in 1990 as an importer and distributor of high quality research immunoassay kits. Since that time, their primary goals have been to offer a diverse line of assays that appeal to their broad customer base while also providing exceptional customer service and product support.