This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ALPCO
product type :
ELISA/assay
product name :
VEGF-R2/KDR ELISA
catalog :
61-KDRHU-E01
quantity :
96 Wells
price :
700.00 USD
product information
Catalog Number :
61-KDRHU-E01
Product Name :
VEGF-R2/KDR ELISA
List Price :
700.00 USD
Description :
VEGF-A (also called VEGF) and its receptors represent the best characterized signalling pathway in developmental and tumour angiogenesis. VEGF-A binds to two receptor-tyrosine kinases: VEGFR-1/Flt-1 and VEGFR-2/KDR. VEGFR-2 is the major mediator of the mitogenic, angiogenic and permeability-enhancing effects of VEGF-A. The VEGFR's possess an approximately 750 amino acid residue extracellular domain, which is organized into seven immunoglobulin (Ig)- like folds. This extracellular domain is followed by a single transmembrane region, a juxtamembrane domain, a split tyrosine-kinase domain interrupted by a 70-amino acid kinase insert and a C-terminal tail. Alternative splicing or proteolytic processing of VEGFR's give rise to secreted variants of VEGFR-2, also called soluble VEGFR-2. Although the VEGFR's are primarily expressed in the vascular system, sensitive methods like sandwich ELISA's have allowed the detection of VEGFR expression in non-endothelial cells like hematopoietic stem cells. Besides its putative role as a surrogate marker for tumour angiogenesis, naturally occurring sVEGFR-2 is a molecular regulator for VEGF and VEGFR signalling.
Therapeutic Areas :
Immunology
Species :
Human
Sample Types :
Cell Culture, Citrate Plasma, EDTA Plasma, Heparin Plasma, Serum
Size :
96 Wells
Regulatory Status :
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution :
Available Worldwide
Applications :
Immunoassays
Sample Size :
50 µL
Range :
78 - 5,000 pg/mL
Sensitivity :
7.0 pg/mL
Incubation Time :
3hr 30min
company information
ALPCO
26G Keewaydin Drive
Salem, NH 03079
email@alpco.com
http://www.alpco.com
1-603-893-8914
headquarters: USA
ALPCO was founded in 1990 as an importer and distributor of high quality research immunoassay kits. Since that time, their primary goals have been to offer a diverse line of assays that appeal to their broad customer base while also providing exceptional customer service and product support.