This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ALPCO
product type :
ELISA/assay
product name :
Monkey IL-8 ELISA
catalog :
61-IL8MK-E01
quantity :
96 Wells
price :
700.00 USD
product information
Catalog Number :
61-IL8MK-E01
Product Name :
Monkey IL-8 ELISA
List Price :
700.00 USD
Description :
Interleukin-8 selectively stimulates the ability of neutrophils and T-lymphocytes to invade injured or inflamed tissue. IL-8 also known as CXCL8 that is purified from peripheral blood monocytes is a 10 kDa protein showing at least 4 variant forms (77, 72, 70, and 69 amino acids, respectively) which differ in the length of the N-terminal and readily form dimers in solution. Two cystin-bridges are essential for the biological activity of IL-8. . Exogenous stimuli like LPS, but also IL-1, TNF-alpha and TNF-beta induce the secretion of IL-8 in a variety of different cell types including monocytes, endothelial and epithelial cells, peripheral blood mononuclear cells, dermal fibroblasts, keratinocytes, neutrophils, hepatocytes, synovial cells, and T-lymphocytes. The activities of IL-8 are not species-specific. Human IL-8 is also active in rodent and rabbit cells and differs from all other cytokines in its ability to specifically activate neutrophil granulocytes. This chemokine activates multiple intracellular signaling pathways downstream of two cell-surface, G protein-coupled receptors (CXCR1 and CXCR2). The property of IL-8 to stimulate movement of neutrophils across endothelial monolayers in vitro supports the concept of a central role for this molecule in the accumulation of neutrophils at inflammatory lesions in vivo.
Therapeutic Areas :
Diabetes & Obesity, Immunology
Species :
Non-Human Primate
Sample Types :
Cell Culture, Serum
Size :
96 Wells
Regulatory Status :
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution :
Available Worldwide
Applications :
Immunoassays
Sample Size :
50 µL
Range :
19.5 - 1,250 U/mL
Sensitivity :
3.0 U/mL
Incubation Time :
3hr 10min
company information
ALPCO
26G Keewaydin Drive
Salem, NH 03079
email@alpco.com
http://www.alpco.com
1-603-893-8914
headquarters: USA
ALPCO was founded in 1990 as an importer and distributor of high quality research immunoassay kits. Since that time, their primary goals have been to offer a diverse line of assays that appeal to their broad customer base while also providing exceptional customer service and product support.