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product summary
company name :
ALPCO
product type :
ELISA/assay
product name :
IL-27 ELISA
catalog :
61-I27HU-E01
quantity :
96 Wells
price :
700.00 USD
product information
Catalog Number :
61-I27HU-E01
Product Name :
IL-27 ELISA
List Price :
700.00 USD
Description :
IL-27 is a member of the IL-12 family, a subgroup of the IL-6 family of cytokines. It is a heterodimer of the subunits EBI3 (Epstein-Barr Virus Induced Gene 3), which is homologous to the p40 subunit shared by IL-12 and IL-23, and p28 (IL-30), which is homologous to p35. IL-27 is produced by activated dendritic cells and macrophages in response to TLR ligands and inflammatory cytokines. . The IL-27 receptor shares one subunit, gp130, with other members of the IL-6 family. The subunit WSX-1 (IL-27Ralpha, TCCR) is unique to IL-27 and is believed to be the only part of the receptor that interacts with the cytokine. The IL-27R is most abundantly expressed on activated T-cells and NK cells, although expression has also been shown on B-cells and na‹ve T-cells. IL-27R activation leads to the phosphorylation of Jak/STAT proteins, with STAT1 and STAT3 being critical to the function of IL-27. IL-27 has been shown to have both pro-inflammatory and anti-inflammatory effects. It influences the commitment of CD4+ T-cells toward the Th1 lineage by inducing the expression of the T-bet transcription factor and the upregulation of IL-12Rbeta2. Its anti-inflammatory functions include the suppression of Th2 and Th17 proliferation and differentiation. Susceptibility to T-cell mediated autoimmunity has been observed in WSX-1 knockout mice.
Therapeutic Areas :
Immunology
Species :
Human
Sample Types :
Cell Culture, Citrate Plasma, EDTA Plasma, Serum
Size :
96 Wells
Regulatory Status :
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution :
Available Worldwide
Applications :
Immunoassays
Sample Size :
50 µL
Range :
62.5 - 4,000 pg/mL
Sensitivity :
9.5 pg/mL
Incubation Time :
3hr 30min
company information
ALPCO
26G Keewaydin Drive
Salem, NH 03079
email@alpco.com
http://www.alpco.com
1-603-893-8914
headquarters: USA
ALPCO was founded in 1990 as an importer and distributor of high quality research immunoassay kits. Since that time, their primary goals have been to offer a diverse line of assays that appeal to their broad customer base while also providing exceptional customer service and product support.