Santa Cruz Antibodies
Mary Johnson (han at labome dot com)
Synatom Research, Princeton, New Jersey, United States
DOI
//dx.doi.org/10.13070/mm.en.2.149
Date
last modified : 2022-10-14; original version : 2012-12-03
Cite as
MATER METHODS 2012;2:149
Abstract

An overview of Santa Cruze antibodies in the literature, and Santa Cruz Biotechnology.

Santa Cruz Biotechnology, often abbreviated as SCBT, founded in 1991, is one of the major suppliers of research antibodies in the world.

Santa Cruz Antibodies figure 1

If you are looking for Santa Cruz Biotechnology antibodies against a specific gene, type in gene name in the box above and click 'search'. In the resultant gene webpage, select 'antibody' link for the correct gene to go to the antibody webpage, and then use "Santa Cruz Biotechnology" filter as the supplier.

Contact Santa Cruz Biotechnology
Website and social media

http://www.scbt.com in English. Besides the English language website, Santa Cruz Biotechnology maintains websites for different languages, including in Chinese (中文: 圣克鲁斯生物技术公司 http://www.scbt.com/zh/). Facebook link: http://www.facebook.com/SantaCruzBiotechnology; Twitter: https://twitter.com/SantaCruzBio. SCBT twitter account regularly posts humorous and delightful comics and drawings.

Email and phone
LocationPhone and timeEmail
US Headquarters1.800.457.3801, 214.902.3900
Customer or Technical Service:7:00 am to 8:00 p.m. CST		scbt@scbt.com
Customer Service:customercare@scbt.com
Europe+00800 4573 8000, +49 6221 4503 0
8:30 a.m. to 6:30 p.m. Central European Time		europe@scbt.com
Asia
  • China
    8:00 a.m. to 6:00 p.m. China Standard Time
    800-820-8626, 21 6093-6350
  • Japan, Korea
    9:00 a.m. to 7:00 p.m. Japan/Korea Standard Time
    001 800-1338-3838
asia@scbio.cn
Table 1. Contact SCBT.
Physical location

SCBT maintains offices in Santa Cruz, California, Paso Robles, California, Sun Valley, Idaho, Heidelberg, Germany (Bergheimer Str. 89-2, 69115 Heidelberg, Germany), and Dallas, Texas. The Santa Cruz address is 2145 Delaware Ave., Santa Cruz, CA 95060. The Headquarters address is 10410 Finnell Street, Dallas, Texas 75220, U.S.A.

Cruz Credit Program and Promotion

SCBT maintains a credit program called Cruz® credit. One Cruz® credit equals to 1 USD or 1 Euro for any purchase of SCBT products or other expenses during purchasing. The credits cannot be refunded or redeemed for cash.

SCBT product users can submit a scientific publication using one or more SCBT products and receive 375 Cruz® Credits or submit a review to receive 15 Credits. Every year, one winner among the submitted articles receives, as Investigator Award, 5000 Cruz® Credits. Cruz® credits can also be obtained through licensing hybridoma clones to SCBT.

Product Range

SCBT provides a diverse array of reagents. They include primary and secondary antibodies, sera, siRNA and shRNA plasmids and lentiviral constructs, cell lysates and tissue extracts, buffers, biochemicals, general labware, and animal health products. SCBT discontinued all its polyclonal antibodies since 2017. Its product catalog numbers are prefixed with "sc-".

Product Num Reference
beta-Actin (C4) Antibody393 [1, 2]
p53 (DO-1) Antibody330 [3, 4]
Oct-3/4 (C-10) Antibody222 [5, 6]
Ub (P4D1) Antibody183 [7, 8]
PCNA (PC10) Antibody177 [9, 10]
p-ERK (E-4) Antibody153 [11, 12]
GAPDH (6C5) Antibody149 [13, 14]
Bcl-2 (C-2) Antibody107 [15, 16]
p21 (F-5) Antibody103 [17, 18]
NFkappaB p65 (F-6) Antibody99 [19, 20]
Chk1 (G-4) Antibody90 [21, 22]
alpha Tubulin (TU-02) Antibody85 [23, 24]
Rho A (26C4) Antibody81 [25, 26]
cyclin B1 (GNS1) Antibody80 [27, 28]
c-Myc (9E10) Antibody76 [29, 30]
p53 (DO-1) X Antibody73 [31, 32]
p53 (DO-1) AC70 [31, 32]
HSC 70 (B-6) Antibody65 [33, 34]
MDM2 (SMP14) Antibody64 [35, 36]
Actin (C-2) Antibody62 [37, 38]
Vimentin (V9) Antibody62 [39, 40]
beta-catenin (E-5) Antibody61 [41, 42]
SQSTM1 (D-3) Antibody59 [43, 44]
alpha Tubulin (B-7) Antibody58 [45, 46]
beta-Actin (ACTBD11B7) Antibody57 [47, 48]
p-JNK (G-7) Antibody55 [49, 50]
GAPDH (0411) Antibody54 [51, 52]
YAP (63.7) Antibody54 [53, 54]
NFkappaB p65 (C-20)54 [55, 56]
PPARgamma (E-8) Antibody53 [57, 58]
Table 2. The most cited antibodies from SCBT in Labome's Validated Antibody Database (VAD) and sample references. Num: number of publications.
Santa Cruz Antibodies in the Literature

Santa Cruz products have been widely used in a variety of research fields. Labome manually reviews formal publications for information about antibody applications to develop Validated Antibody Database (VAD). Among those articles citing Santa Cruz reagents, the most cited antibodies are listed in Table 2. These numbers of publications are those that are included in VAD among the formal publications reviewed by Labome. The actual numbers for each product are much higher.

Its antibody sc-47778 is one of most commonly used for detecting Western blot loading control beta-actin. Its GAPDH antibody sc-32233 is also a commonly used Western blot loading control. Here are some more recent examples of Santa Cruz antibodies in the literature. G Dixon et al stained embroynic stem cell line with an anti-OCT4 antibody from Santa Cruz ( sc-5279) as a marker of pluripotency [59]. H Kim et al detected cyclin E in cell lysates with mouse monoclonal sc-247 antibody [60]. Y Shwartz et al labeled the arrector pili muscle with mouse monoclonal anti-smooth muscle actin antibody sc-32251 [61]. L Pellegrini et al stained LAT-1 transporter in choroid plexus organoids with sc-374232 antibody [62]. Virk HS et al evaluated two lesser used monoclonals and three commonly cited polyclonals against TRPA1 and found that Santa Cruz sc-376495 was specific in Western blot, immunocytochemistry and flow cytometry [63]. Ladinsky MS et al detected early endosomes on terminal ileum paraffin sections from mice with Santa Cruz mouse monoclonal sc-137130 EEA1 antibody [64]. van de Kooij B et al detected the Plk1 protein from an in vitro kinase assay with Santa Cruz Biotechnology mouse monoclonal anti-Plk1 antibody (Cat# sc-17783) in western blots at 1:100 dilution [65]. Moro A et al used SCBT mouse monoclonal Rho B antibody (C-5) ( sc-8048) to detect Rho B protein in HUVEC lysates in Western blot [66].

Where to Meet?

Santa Cruz Biotechnology does not exhibit at the meetings like SFN, AACR, ASCB, or Pittcon. If you have any questions, it is encouraged that you email or phone SCBT, see the contact information above.

References
  1. Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, et al. Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat Commun. 2015;6:6156 pubmed publisher
  2. Shenton M, Ballinger R, Marcy B, Faux S, Cane M, LeMay M, et al. Two syndromes of schizophrenic psychopathology associated with left vs. right temporal deficits in P300 amplitude. Four case reports. J Nerv Ment Dis. 1989;177:219-25 pubmed
  3. Zhao J, Zhao D, Poage G, Mazumdar A, Zhang Y, Hill J, et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015;125:2707-20 pubmed publisher
  4. Oyanagui Y. [Possible clinical application of SOD and free radical scavengers]. Rinsho Byori. 1989;37:999-1005 pubmed
  5. Morales Hernández A, González Rico F, Román A, Rico Leo E, Alvarez Barrientos A, Sánchez L, et al. Alu retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor. Nucleic Acids Res. 2016;44:4665-83 pubmed publisher
  6. Cooper A, Hollander M, Anders M. Formation of highly reactive vinylglyoxylate (2-oxo-3-butenoate) from amino acids with good leaving groups in the gamma-position. Toxicological implications and therapeutic potential. Biochem Pharmacol. 1989;38:3895-901 pubmed
  7. Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, et al. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017;18:54-63 pubmed publisher
  8. Monefeldt K, Tollefsen T. Serum IgG antibodies reactive with lipoteichoic acid in adult patients with periodontitis. J Clin Periodontol. 1989;16:519-24 pubmed
  9. Guan C, Zhang J, Zhang J, Shi H, Ni R. Enhanced expression of early mitotic inhibitor-1 predicts a poor prognosis in esophageal squamous cell carcinoma patients. Oncol Lett. 2016;12:114-120 pubmed
  10. Neri B, Cini Neri G, Bandinelli M, Pacini P, Bartalucci S, Ciapini A. Doxorubicin and epirubicin cardiotoxicity: experimental and clinical aspects. Int J Clin Pharmacol Ther Toxicol. 1989;27:217-21 pubmed
  11. Wang H, Han X, Bretz C, Becker S, Gambhir D, Smith G, et al. Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization. Mol Ther Methods Clin Dev. 2016;3:16056 pubmed publisher
  12. Reither M. [Indications for magnetic resonance tomography in diseases of the central nervous system in children]. Padiatr Padol. 1989;24:123-35 pubmed
  13. Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, et al. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016;473:2671-85 pubmed publisher
  14. Eriksson L, Wollmer P, Olsson C, Albrechtsson U, Larusdottir H, Nilsson R, et al. Diagnosis of pulmonary embolism based upon alveolar dead space analysis. Chest. 1989;96:357-62 pubmed
  15. Chiang C, Hong Y. In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy. Sci Rep. 2021;11:18172 pubmed publisher
  16. Ali A, Kuo W, Kuo C, Lo J, Chen M, Daddam J, et al. E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages. Bioeng Transl Med. 2021;6:e10234 pubmed publisher
  17. Prekovic S, Schuurman K, Mayayo Peralta I, Manjón A, Buijs M, Yavuz S, et al. Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. Nat Commun. 2021;12:4360 pubmed publisher
  18. Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed publisher
  19. Zheng J, Yao L, Zhou Y, Gu X, Wang C, Bao K, et al. A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. Cell Death Dis. 2021;12:871 pubmed publisher
  20. Yadav A, Huang T, Chen S, Ramasamy T, Hsueh Y, Lin S, et al. Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination. J Neuroinflammation. 2021;18:238 pubmed publisher
  21. Ho K, Luo H, Zhu W, Tang Y. Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Sci Rep. 2021;11:7502 pubmed publisher
  22. Barger C, Chee L, Albahrani M, Munoz Trujillo C, Boghean L, Branick C, et al. Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer. elife. 2021;10: pubmed publisher
  23. Zhang H, Shang R, Bi P. Feedback regulation of Notch signaling and myogenesis connected by MyoD-Dll1 axis. PLoS Genet. 2021;17:e1009729 pubmed publisher
  24. Sabbir M, Taylor C, Zahradka P. CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner. Cell Commun Signal. 2021;19:98 pubmed publisher
  25. Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
  26. Xu J, Wen J, Fu L, Liao L, Zou Y, Zhang J, et al. Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice. J Neuroinflammation. 2021;18:234 pubmed publisher
  27. Langhans M, Gao J, Tang Y, Wang B, Alexander P, Tuan R. Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling. BMC Dev Biol. 2021;21:10 pubmed publisher
  28. Lou X, Ning J, Liu W, Li K, Qian B, Xu D, et al. YTHDF1 Promotes Cyclin B1 Translation through m6A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation. Cells. 2021;10: pubmed publisher
  29. Biswas A, Zhou D, Fiches G, Wu Z, Liu X, Ma Q, et al. Inhibition of polo-like kinase 1 (PLK1) facilitates reactivation of gamma-herpesviruses and their elimination. PLoS Pathog. 2021;17:e1009764 pubmed publisher
  30. Lee J, Hong J, Zhang Z, de la Peña Avalos B, Proietti C, Deamicis A, et al. Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A). Sci Adv. 2021;7: pubmed publisher
  31. Singh S, Abu Zaid A, Lin W, Low J, Abdolvahabi A, Jin H, et al. 17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma. iScience. 2021;24:101996 pubmed publisher
  32. Kim C, Jin J, Ye Z, Jadhav R, Gustafson C, Hu B, et al. Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021;131: pubmed publisher
  33. Kemper M, Schiecke A, Maar H, Nikulin S, Poloznikov A, Galatenko V, et al. Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression. J Exp Clin Cancer Res. 2021;40:214 pubmed publisher
  34. Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, et al. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model. Protein Cell. 2021;: pubmed publisher
  35. Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
  36. Kanellis D, Espinoza J, Zisi A, Sakkas E, Bartkova J, Katsori A, et al. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output. Sci Adv. 2021;7: pubmed publisher
  37. Rodríguez Baena F, Redondo García S, Peris Torres C, Martino Echarri E, Fernández Rodríguez R, Plaza Calonge M, et al. ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response. Sci Rep. 2018;8:13103 pubmed publisher
  38. Singh V, Khalil M, De Benedetti A. The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1. Cell Cycle. 2020;19:363-375 pubmed publisher
  39. Du J, Yu Q, Liu Y, Du S, Huang L, Xu D, et al. A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Theranostics. 2021;11:4207-4231 pubmed publisher
  40. Hua X, Ge S, Zhang M, Mo F, Zhang L, Zhang J, et al. Pathogenic Roles of CXCL10 in Experimental Autoimmune Prostatitis by Modulating Macrophage Chemotaxis and Cytokine Secretion. Front Immunol. 2021;12:706027 pubmed publisher
  41. Baeza V, Cifuentes M, Martinez F, Ramírez E, Nualart F, Ferrada L, et al. IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment. Sci Rep. 2021;11:18537 pubmed publisher
  42. Zhu H, Su Z, Ning J, Zhou L, Tan L, Sayed S, et al. Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer. Cell Death Dis. 2021;12:912 pubmed publisher
  43. Ray U, Roy D, Jin L, Thirusangu P, Staub J, Xiao Y, et al. Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. J Exp Clin Cancer Res. 2021;40:182 pubmed publisher
  44. Zhang H, Yang X, Zhu L, Li Z, Zuo P, Wang P, et al. ASPM promotes hepatocellular carcinoma progression by activating Wnt/β-catenin signaling through antagonizing autophagy-mediated Dvl2 degradation. FEBS Open Bio. 2021;11:2784-2799 pubmed publisher
  45. Fischietti M, Eckerdt F, Blyth G, Arslan A, Mati W, Oku C, et al. Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma. Oncogene. 2021;40:3273-3286 pubmed publisher
  46. Rivero Hinojosa S, Pugacheva E, Kang S, Mendez Catala C, Kovalchuk A, Strunnikov A, et al. The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis. Nat Commun. 2021;12:3846 pubmed publisher
  47. Loh J, Xu S, Huo J, Kim S, Wang Y, Lam K. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717-2729 pubmed publisher
  48. Chen Y, Waqar A, Nishijima K, Ning B, Kitajima S, Matsuhisa F, et al. Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits. J Cell Mol Med. 2020;24:4261-4274 pubmed publisher
  49. Siu M, Jiang Y, Wang J, Leung T, Ngu S, Cheung A, et al. PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling. Oncogenesis. 2020;9:24 pubmed publisher
  50. Zulfiqar Z, Shah F, Shafique S, Alattar A, Ali T, Alvi A, et al. Repurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats. J Inflamm Res. 2020;13:1185-1205 pubmed publisher
  51. You X, Wu J, Zhao X, Jiang X, Tao W, Chen Z, et al. Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer. Aging (Albany NY). 2021;13:18464-18481 pubmed publisher
  52. Zhang L, Yao L, Zhou W, Tian J, Ruan B, Lu Z, et al. miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling. Mol Ther Nucleic Acids. 2021;25:567-577 pubmed publisher
  53. Pocaterra A, Scattolin G, Romani P, Ament C, Ribback S, Chen X, et al. Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development. Commun Biol. 2021;4:763 pubmed publisher
  54. Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher
  55. Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al. E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021;12:3582 pubmed publisher
  56. Goyette M, Elkholi I, Apcher C, Kuasne H, Rothlin C, Muller W, et al. Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  57. Sferra R, Pompili S, Cappariello A, Gaudio E, Latella G, Vetuschi A. Prolonged Chronic Consumption of a High Fat with Sucrose Diet Alters the Morphology of the Small Intestine. Int J Mol Sci. 2021;22: pubmed publisher
  58. Cheng V, Reddam A, Bhatia A, Hur M, Kirkwood J, Volz D. Utilizing systems biology to reveal cellular responses to peroxisome proliferator-activated receptor γ ligand exposure. Curr Res Toxicol. 2021;2:169-178 pubmed publisher
  59. Dixon G, Pan H, Yang D, Rosen B, Jashari T, Verma N, et al. QSER1 protects DNA methylation valleys from de novo methylation. Science. 2021;372: pubmed publisher
  60. Kim H, Kim J, Yu S, Lee Y, Park J, Choi R, et al. A Mechanism for microRNA Arm Switching Regulated by Uridylation. Mol Cell. 2020;78:1224-1236.e5 pubmed publisher
  61. Shwartz Y, Gonzalez Celeiro M, Chen C, Pasolli H, Sheu S, Fan S, et al. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells. Cell. 2020;: pubmed publisher
  62. Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed publisher
  63. Virk H, Rekas M, Biddle M, Wright A, Sousa J, Weston C, et al. Validation of antibodies for the specific detection of human TRPA1. Sci Rep. 2019;9:18500 pubmed publisher
  64. Ladinsky M, Araujo L, Zhang X, Veltri J, Galán Díez M, Soualhi S, et al. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science. 2019;363: pubmed publisher
  65. van de Kooij B, Creixell P, van Vlimmeren A, Joughin B, Miller C, Haider N, et al. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. elife. 2019;8: pubmed publisher
  66. Moro A, Driscoll T, Boraas L, Armero W, Kasper D, Baeyens N, et al. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis. Nat Cell Biol. 2019;21:348-358 pubmed publisher
ISSN : 2329-5139