This is a Validated Antibody Database (VAD) review about sheep LOC101121024, based on 27 published articles (read how Labome selects the articles), using LOC101121024 antibody in all methods. It is aimed to help Labome visitors find the most suited LOC101121024 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LOC101121024 synonym: MAPT; microtubule-associated protein tau

Invitrogen
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:1000; loading ...; fig 4b
In order to evaluate the efficacy of an orally bioactive and brain permeable gamma-secretase inhibitor in a mouse model of Alzheimer's disease, Invitrogen LOC101121024 antibody (Thermo, MA5-12805) was used in western blot on mouse samples at 1:1000 (fig 4b). Nat Commun (2017) ncbi
mouse monoclonal (Tau-5)
  • immunocytochemistry; rat; 1:1000; loading ...; fig s1a
In order to study the role of SNARE machinery in neuronal polarity and selective protein targeting, Invitrogen LOC101121024 antibody (Invitrogen, Tau-5) was used in immunocytochemistry on rat samples at 1:1000 (fig s1a). PLoS ONE (2016) ncbi
mouse monoclonal (Tau-5)
  • western blot; human; 1:10,000; fig 3f
In order to investigate the role of channel gating in mammalian proteasomes, Invitrogen LOC101121024 antibody (Invitrogen, Tau-5) was used in western blot on human samples at 1:10,000 (fig 3f). Nat Commun (2016) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:1000; tbl 1
  • western blot; human; 1:1000; tbl 1
In order to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice, Invitrogen LOC101121024 antibody (Thermo Fisher, TAU-5) was used in western blot on mouse samples at 1:1000 (tbl 1) and in western blot on human samples at 1:1000 (tbl 1). Front Cell Neurosci (2015) ncbi
mouse monoclonal (Tau-5)
  • western blot; cat; 1:1000; fig 4
In order to study Alzheimer's disease by use of a domestic cat animal model, Invitrogen LOC101121024 antibody (Life Technologies, TAU-5) was used in western blot on cat samples at 1:1000 (fig 4). Acta Neuropathol Commun (2015) ncbi
mouse monoclonal (Tau-5)
  • immunohistochemistry - paraffin section; human; 1:500; fig 2
  • western blot; human; 1:1000; fig 4
In order to evaluate motor function and tau pathology of P301S tau transgenic mice, Invitrogen LOC101121024 antibody (Invitrogen, TAU5) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 2) and in western blot on human samples at 1:1000 (fig 4). Mol Neurodegener (2014) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; fig 2
In order to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology, Invitrogen LOC101121024 antibody (Invitrogen, Tau5) was used in western blot on mouse samples (fig 2). Front Aging Neurosci (2014) ncbi
mouse monoclonal (Tau-5)
  • immunohistochemistry; mouse; 1:3000
In order to assess if tau reduction benefits intractable genetic epilepsies, Invitrogen LOC101121024 antibody (Life Technologies, tau-5) was used in immunohistochemistry on mouse samples at 1:3000. Ann Neurol (2014) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:500
In order to study how induction of Calyculin A in N2a cells can attenuate axonal transport impairment and axonopathy by Berberine, Invitrogen LOC101121024 antibody (NeoMarkers, tau-5) was used in western blot on mouse samples at 1:500. PLoS ONE (2014) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:4000
In order to identify a method for simultaneous use of both biochemistry and immunohistochemistry in regards to the same tissue, Invitrogen LOC101121024 antibody (Thermo Fisher Scientific, Tau-5) was used in western blot on mouse samples at 1:4000. Eur J Neurosci (2014) ncbi
mouse monoclonal (Tau-5)
  • western blot; human; 1:200; fig 2
In order to study the ability of pharmacological activation of AMPK to protect a human neuroblastoma cell line against homocysteine-induced toxicity, Invitrogen LOC101121024 antibody (Lab Vision, MS-247-P0) was used in western blot on human samples at 1:200 (fig 2). Neurochem Res (2013) ncbi
mouse monoclonal (Tau-5)
  • immunohistochemistry; human; 1:1000
  • western blot; human; 1:1000; fig 3
  • western blot; rat; 1:1000
In order to study changes in autophagy and the roles of Tau hyperphosphorylation and fractalkine in an animal model of Abeta42-induced Tau hyperphosphorylation, Invitrogen LOC101121024 antibody (Thermo Scientific, Tau-5) was used in immunohistochemistry on human samples at 1:1000, in western blot on human samples at 1:1000 (fig 3) and in western blot on rat samples at 1:1000. Exp Neurol (2014) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; fig 3
In order to investigate the contribution of Ang II to Alzheimer disease, Invitrogen LOC101121024 antibody (Invitrogen, Tau-5) was used in western blot on mouse samples (fig 3). FEBS Lett (2012) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; fig 1
In order to investigate interactions between MAP2 and PP2A/Balpha in the brain, Invitrogen LOC101121024 antibody (BIOSOURCE, Tau-5) was used in western blot on mouse samples (fig 1). J Biol Chem (2012) ncbi
mouse monoclonal (Tau-5)
  • ELISA; human; fig 1a
In order to test if HFE polymorphisms are associated with alterations in tau phosphorylation in a human neuroblastoma cell line, Invitrogen LOC101121024 antibody (Biosource International, Tau-5) was used in ELISA on human samples (fig 1a). Neurobiol Aging (2011) ncbi
mouse monoclonal (Tau-5)
  • western blot; rat; 1:1000; fig 3
In order to assess the neuroprotective effects of delphinidin against Abeta-induced toxicity, Invitrogen LOC101121024 antibody (Biosource, tau-5) was used in western blot on rat samples at 1:1000 (fig 3). Biosci Biotechnol Biochem (2009) ncbi
mouse monoclonal (Tau-5)
  • western blot; rat; 1:1000
In order to investigate the potential neuroprotective effects of caffeic acid against Abeta-induced toxicity, Invitrogen LOC101121024 antibody (Biosource, tau-5) was used in western blot on rat samples at 1:1000. Life Sci (2009) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:1000
In order to investigate the neurotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin, Invitrogen LOC101121024 antibody (Biosource, tau-5) was used in western blot on mouse samples at 1:1000. Toxicology (2009) ncbi
mouse monoclonal (Tau-5)
  • immunocytochemistry; rat; 1:200
In order to develop an electrophysiologically active 3D neural construct with neurons and astrocytes encased in a bioactive extracellular matrix-based scaffold, Invitrogen LOC101121024 antibody (NeoMarkers, MS247P) was used in immunocytochemistry on rat samples at 1:200. J Neural Eng (2008) ncbi
mouse monoclonal (Tau-5)
  • western blot; rat; 1:1000; fig 6
In order to elucidate the neuroprotective mechanisms by which curcumin protects against Abeta-induced toxicity, Invitrogen LOC101121024 antibody (Biosource, tau-5) was used in western blot on rat samples at 1:1000 (fig 6). Food Chem Toxicol (2008) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:1000; fig 5
In order to determine that Abeta deposition or oestrogen deficiency increases PP2A phosphorylation to compromise tau dephosphorylation and cause neurofibrillary tangle formation in Alzheimer's disease, Invitrogen LOC101121024 antibody (Biosource, Tau-5) was used in western blot on mouse samples at 1:1000 (fig 5). J Cell Mol Med (2008) ncbi
mouse monoclonal (Tau-5)
  • western blot; rat; 1:5000
In order to evaluate five glycogen synthase kinase-3beta inhibitors and lithium in lowering phosphorylated tau and glycogen synthase kinase-3beta enzyme activity levels in 12-day old postnatal rats, Invitrogen LOC101121024 antibody (BioSource/Invitrogen, tau-5) was used in western blot on rat samples at 1:5000. Br J Pharmacol (2007) ncbi
mouse monoclonal (Tau-5)
  • western blot; rat; 1:1000; fig 3
In order to test if sex hormones prevent tau cleavage and Abeta toxicity, Invitrogen LOC101121024 antibody (Biosource, tau-5) was used in western blot on rat samples at 1:1000 (fig 3). Neuroscience (2007) ncbi
mouse monoclonal (Tau-5)
  • immunohistochemistry - paraffin section; human; 1:10,000; tbl 1
  • western blot; human; 1:10,000; tbl 1
In order to characterize a new mouse model of Alzheimer's disease, Invitrogen LOC101121024 antibody (Biosource, Tau-5) was used in immunohistochemistry - paraffin section on human samples at 1:10,000 (tbl 1) and in western blot on human samples at 1:10,000 (tbl 1). Am J Pathol (2006) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse
In order to assess the effects lithium chloride on cold water stress-induced changes in tau phosphorylation in the mouse hippocampus, Invitrogen LOC101121024 antibody (Biosource, TAU-5) was used in western blot on mouse samples . J Neural Transm (Vienna) (2006) ncbi
mouse monoclonal (Tau-5)
  • western blot; mouse; 1:1000
In order to elucidate how the removal of assembled neurofilaments from axons or misaccumulating neurofilaments in motor neuron cell bodies slows disease in a mouse model of amyotrophic lateral sclerosis, Invitrogen LOC101121024 antibody (BioSource, Tau-5) was used in western blot on mouse samples at 1:1000. Proc Natl Acad Sci U S A (2005) ncbi
mouse monoclonal (Tau-5)
  • western blot; rat
In order to test if calpain cleave the cyclin-dependent kinase 5 activator p35 to a p25 fragment and results in tau hyperphosphorylation, Invitrogen LOC101121024 antibody (BioSource, tau-5) was used in western blot on rat samples . Biochem Biophys Res Commun (2002) ncbi
Articles Reviewed
  1. Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017;8:14740 pubmed publisher
  2. Soo Hoo L, Banna C, Radeke C, Sharma N, Albertolle M, Low S, et al. The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. PLoS ONE. 2016;11:e0163671 pubmed publisher
  3. Choi W, de Poot S, Lee J, Kim J, Han D, Kim Y, et al. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016;7:10963 pubmed publisher
  4. Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
  5. Chambers J, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, et al. The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun. 2015;3:78 pubmed publisher
  6. Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed publisher
  7. Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed publisher
  8. Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed publisher
  9. Liu X, Zhou J, Abid M, Yan H, Huang H, Wan L, et al. Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. PLoS ONE. 2014;9:e93974 pubmed publisher
  10. Notter T, Panzanelli P, PFISTER S, Mircsof D, Fritschy J. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system. Eur J Neurosci. 2014;39:165-75 pubmed publisher
  11. Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed publisher
  12. Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed publisher
  13. Tian M, Zhu D, Xie W, Shi J. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 2012;586:3737-45 pubmed publisher
  14. Sontag J, Nunbhakdi Craig V, White C, Halpain S, Sontag E. The protein phosphatase PP2A/B? binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. J Biol Chem. 2012;287:14984-93 pubmed publisher
  15. Hall E, Lee S, Mairuae N, Simmons Z, Connor J. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011;32:1409-19 pubmed publisher
  16. Kim H, Sul D, Lim J, Lee D, Joo S, Hwang K, et al. Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. Biosci Biotechnol Biochem. 2009;73:1685-9 pubmed
  17. Sul D, Kim H, Lee D, Joo S, Hwang K, Park S. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation. Life Sci. 2009;84:257-62 pubmed publisher
  18. Sul D, Kim H, Cho E, Lee M, Kim H, Jung W, et al. 2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation. Toxicology. 2009;255:65-71 pubmed publisher
  19. Irons H, Cullen D, Shapiro N, Lambert N, Lee R, LaPlaca M. Three-dimensional neural constructs: a novel platform for neurophysiological investigation. J Neural Eng. 2008;5:333-41 pubmed publisher
  20. Park S, Kim H, Cho E, Kwon B, Phark S, Hwang K, et al. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol. 2008;46:2881-7 pubmed publisher
  21. Liu R, Zhou X, Tanila H, Bjorkdahl C, Wang J, Guan Z, et al. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med. 2008;12:241-57 pubmed publisher
  22. Selenica M, Jensen H, Larsen A, Pedersen M, Helboe L, Leist M, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007;152:959-79 pubmed
  23. Park S, Tournell C, Sinjoanu R, Ferreira A. Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons. Neuroscience. 2007;144:119-27 pubmed
  24. Schindowski K, Bretteville A, Leroy K, Bégard S, Brion J, Hamdane M, et al. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006;169:599-616 pubmed
  25. Yoshida S, Maeda M, Kaku S, Ikeya H, Yamada K, Nakaike S. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. J Neural Transm (Vienna). 2006;113:1803-14 pubmed
  26. Lobsiger C, Garcia M, Ward C, Cleveland D. Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A. 2005;102:10351-6 pubmed
  27. Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T. Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation. Biochem Biophys Res Commun. 2002;298:693-8 pubmed