This is a Validated Antibody Database (VAD) review about rat presenilin 2, based on 8 published articles (read how Labome selects the articles), using presenilin 2 antibody in all methods. It is aimed to help Labome visitors find the most suited presenilin 2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Knockout validation
Abcam
domestic rabbit monoclonal (EP1515Y)
  • western blot knockout validation; mouse; fig 6a
In order to assess the effects of presenilin dosage on cortical neuron survival in mice, Abcam presenilin 2 antibody (Abcam, ab51249) was used in western blot knockout validation on mouse samples (fig 6a). J Neurosci (2014) ncbi
Abcam
domestic rabbit monoclonal (EP1515Y)
  • western blot; mouse; loading ...; fig 2a
Abcam presenilin 2 antibody (Abcam, EP-1515Y) was used in western blot on mouse samples (fig 2a). J Cell Biol (2019) ncbi
domestic rabbit monoclonal (EP1515Y)
  • western blot knockout validation; mouse; fig 6a
In order to assess the effects of presenilin dosage on cortical neuron survival in mice, Abcam presenilin 2 antibody (Abcam, ab51249) was used in western blot knockout validation on mouse samples (fig 6a). J Neurosci (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D30G3)
  • western blot; human; 1:1000; fig s7f
Cell Signaling Technology presenilin 2 antibody (Cell Signaling, 9979) was used in western blot on human samples at 1:1000 (fig s7f). Signal Transduct Target Ther (2021) ncbi
domestic rabbit monoclonal (D30G3)
  • western blot; mouse; 1:1000; loading ...; fig s3f
Cell Signaling Technology presenilin 2 antibody (Cell Signaling Technology, 9979) was used in western blot on mouse samples at 1:1000 (fig s3f). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (D30G3)
  • western blot; human; fig s2
Cell Signaling Technology presenilin 2 antibody (Cell Signaling Tech, 9979) was used in western blot on human samples (fig s2). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D30G3)
  • western blot; human
In order to investigate presenilin assembly and catalytic activity, Cell Signaling Technology presenilin 2 antibody (Cell Signaling, D30G3) was used in western blot on human samples . J Biol Chem (2015) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; rat; 1:1000
  • western blot; rat; 1:1000
Cell Signaling Technology presenilin 2 antibody (Cell Signaling Technology, 2192S) was used in immunohistochemistry - paraffin section on rat samples at 1:1000 and in western blot on rat samples at 1:1000. Mol Neurobiol (2016) ncbi
domestic rabbit monoclonal (D30G3)
  • western blot; human; loading ...; fig 6b
Cell Signaling Technology presenilin 2 antibody (Cell Signaling Technology Inc., 9979) was used in western blot on human samples (fig 6b). Mol Carcinog (2015) ncbi
Articles Reviewed
  1. Luo R, Fan Y, Yang J, Ye M, Zhang D, Guo K, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduct Target Ther. 2021;6:325 pubmed publisher
  2. Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
  3. Liu L, Ding L, Rovere M, Wolfe M, Selkoe D. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. J Cell Biol. 2019;218:644-663 pubmed publisher
  4. Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed publisher
  5. Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero A, Dewachter I, et al. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem. 2015;290:7169-84 pubmed publisher
  6. Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher
  7. Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher
  8. Watanabe H, Iqbal M, Zheng J, Wines Samuelson M, Shen J. Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci. 2014;34:15912-22 pubmed publisher