This is a Validated Antibody Database (VAD) review about rat caspase 8, based on 43 published articles (read how Labome selects the articles), using caspase 8 antibody in all methods. It is aimed to help Labome visitors find the most suited caspase 8 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
caspase 8 synonym: CASP-8

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D35G2)
  • western blot knockout validation; mouse; fig s4b
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot knockout validation on mouse samples (fig s4b). J Clin Invest (2022) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4c
Abcam caspase 8 antibody (Abcam, ab25901) was used in western blot on mouse samples (fig 4c). Cell Death Dis (2022) ncbi
domestic rabbit polyclonal
  • western blot; rat; 1:1000; fig 7a
Abcam caspase 8 antibody (Abcam, ab25901) was used in western blot on rat samples at 1:1000 (fig 7a). J Neuroinflammation (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 8
Abcam caspase 8 antibody (Abcam, ab25901) was used in western blot on human samples (fig 8). Biomolecules (2020) ncbi
domestic rabbit monoclonal (EPR162)
  • western blot; bovine; 1:1000; loading ...; fig 2b
Abcam caspase 8 antibody (Abcam, ab108333) was used in western blot on bovine samples at 1:1000 (fig 2b). BMC Vet Res (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:3000; loading ...; fig s5
  • western blot; rat; fig s5
Abcam caspase 8 antibody (Abcam, ab 25,901) was used in western blot on human samples at 1:3000 (fig s5) and in western blot on rat samples (fig s5). J Exp Clin Cancer Res (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 6b
Abcam caspase 8 antibody (Abcam, ab25901) was used in western blot on mouse samples (fig 6b). Autophagy (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; loading ...; fig s8
Abcam caspase 8 antibody (Abcam, ab25901) was used in immunohistochemistry on human samples (fig s8). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3b
Abcam caspase 8 antibody (Abcam, ab25901) was used in western blot on human samples at 1:1000 (fig 3b). Mol Med Rep (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; rat; 1:500; fig 6a
In order to examine the effects of hypothyroidism on late lactation, Abcam caspase 8 antibody (Abcam, ab25901) was used in immunohistochemistry - paraffin section on rat samples at 1:500 (fig 6a). Mol Cell Endocrinol (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (1.1.40)
  • western blot; mouse; fig 1d
Santa Cruz Biotechnology caspase 8 antibody (Santa Cruz Biotechnology, sc-81656) was used in western blot on mouse samples (fig 1d). Int J Mol Med (2016) ncbi
mouse monoclonal (1.1.40)
  • western blot; human; 1:200; fig 7
Santa Cruz Biotechnology caspase 8 antibody (santa Cruz, sc-81656) was used in western blot on human samples at 1:200 (fig 7). Mol Med Rep (2015) ncbi
mouse monoclonal (8CSP01)
  • western blot; human; fig 8
Santa Cruz Biotechnology caspase 8 antibody (santa Cruz, sc-81661) was used in western blot on human samples (fig 8). PLoS ONE (2015) ncbi
mouse monoclonal (E-8)
  • western blot; rat; 1:1000
Santa Cruz Biotechnology caspase 8 antibody (Santa Cruz Biotechnology, sc-166320) was used in western blot on rat samples at 1:1000. World J Biol Chem (2014) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:25; fig 2c
  • western blot; human; loading ...; fig 1b
In order to assess the prognostic potential of caspase-3 and -8 and calpain in breast cancer, Invitrogen caspase 8 antibody (Thermo, PA1-29159) was used in immunohistochemistry on human samples at 1:25 (fig 2c) and in western blot on human samples (fig 1b). Apoptosis (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4c
In order to investigate the role of IL-1beta produced by a T helper 17 cell-intrinsic ASC-NLRP3-caspase-8 inflammasome in experimental autoimmune encephalomyelitis, Invitrogen caspase 8 antibody (Thermo Fisher, PA1-29159) was used in western blot on mouse samples at 1:1000 (fig 4c). Nat Immunol (2016) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3c
Novus Biologicals caspase 8 antibody (Novus, NB100-56116) was used in western blot on mouse samples (fig 3c). Cell Death Dis (2022) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1d
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 9429) was used in western blot on mouse samples at 1:1000 (fig 1d). Immunity (2022) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot knockout validation; mouse; fig s4b
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot knockout validation on mouse samples (fig s4b). J Clin Invest (2022) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; loading ...; fig 3f
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot on mouse samples (fig 3f). Front Immunol (2021) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; loading ...; fig 1b, 1c
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot on human samples (fig 1b, 1c). Cell Death Differ (2020) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; loading ...; fig 3d
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, 4790) was used in western blot on human samples (fig 3d). Theranostics (2020) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; loading ...; fig 3d
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, 4790) was used in western blot on mouse samples (fig 3d). Cell (2019) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; loading ...; fig s1g
Cell Signaling Technology caspase 8 antibody (Cell Signaling, D35G2) was used in western blot on mouse samples (fig s1g). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2e
Cell Signaling Technology caspase 8 antibody (cell Signaling, 9429) was used in western blot on mouse samples (fig 2e). Nature (2018) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, D35G2) was used in western blot on mouse samples (fig 2a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; 1:1000; fig 5e
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, D35G2) was used in western blot on human samples at 1:1000 (fig 5e). Immun Inflamm Dis (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1c
  • western blot; human; loading ...; fig 1f
Cell Signaling Technology caspase 8 antibody (cell signalling, 9429) was used in western blot on mouse samples (fig 1c) and in western blot on human samples (fig 1f). EMBO J (2017) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; fig 4
In order to elucidate the mechanism by which RIPK1 counteracts RIPK3-MLKL-mediated necroptosis, Cell Signaling Technology caspase 8 antibody (Cell signaling, 4790) was used in western blot on mouse samples (fig 4). Nature (2016) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; 1:1000; fig s15
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot on human samples at 1:1000 (fig s15). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 1
In order to analyze induction of efficient anti-tumor immunity by vaccination with necroptotic cancer cells, Cell Signaling Technology caspase 8 antibody (Cell Signaling, 9429) was used in western blot on mouse samples (fig 1). Cell Rep (2016) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; loading ...; fig 1c
In order to report how the parallel networks of necroptosis-induced CXCL1 and Mincle signaling promote pancreatic ductal adenocarcinoma progression, Cell Signaling Technology caspase 8 antibody (Cell Signaling, D35G2) was used in western blot on human samples (fig 1c). Nature (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 8
Cell Signaling Technology caspase 8 antibody (Cell Signaling Tech, 9429) was used in western blot on mouse samples at 1:1000 (fig 8). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; fig 7
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, 4790) was used in western blot on human samples (fig 7). Oncotarget (2015) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; rat; 1:1000
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, 4790) was used in western blot on rat samples at 1:1000. Mol Med Rep (2015) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; rat; 1:1000; fig 4
In order to elucidate ketamine-induced ulcerative cystitis and bladder apoptosis in association with oxidative stress mediated by mitochondria and the endoplasmic reticulum, Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot on rat samples at 1:1000 (fig 4). Am J Physiol Renal Physiol (2015) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; fig 4c
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in western blot on mouse samples (fig 4c). Cell Death Dis (2015) ncbi
domestic rabbit monoclonal (D35G2)
  • immunocytochemistry; human
  • western blot; rat
Cell Signaling Technology caspase 8 antibody (Cell Signaling, 4790) was used in immunocytochemistry on human samples and in western blot on rat samples . Toxicol Lett (2015) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; mouse; 1:1000
In order to study the role of Musashi-1 in blood-testis barrier structure during spermatogenesis, Cell Signaling Technology caspase 8 antibody (CST, 4790) was used in western blot on mouse samples at 1:1000. Mol Biol Cell (2015) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; 1:2000; fig 6
  • western blot; mouse; 1:2000; fig 1
Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, 4790) was used in western blot on human samples at 1:2000 (fig 6) and in western blot on mouse samples at 1:2000 (fig 1). Nat Commun (2014) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; 1:500
In order to study the role of p150glued in apoptosis, Cell Signaling Technology caspase 8 antibody (Cell Signaling Technology, 4790) was used in western blot on human samples at 1:500. PLoS ONE (2014) ncbi
domestic rabbit monoclonal (D35G2)
  • western blot; human; 1:1000
Cell Signaling Technology caspase 8 antibody (Cell Signaling, D35G2) was used in western blot on human samples at 1:1000. PLoS ONE (2014) ncbi
BioVision
  • western blot; rat; 1:1000; loading ...; fig 8a
BioVision caspase 8 antibody (BioVision, 3259-100) was used in western blot on rat samples at 1:1000 (fig 8a). BMC Complement Altern Med (2015) ncbi
ProSci
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s1j
ProSci caspase 8 antibody (ProSci, 3473) was used in western blot on human samples (fig s1j). Nature (2016) ncbi
Articles Reviewed
  1. Chen J, Chen K, Wang L, Luo J, Zheng Q, He Y. Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy. Cell Death Dis. 2022;13:522 pubmed publisher
  2. Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher
  3. Simpson D, Pang J, Weir A, Kong I, Fritsch M, Rashidi M, et al. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022;55:423-441.e9 pubmed publisher
  4. Rusu I, Mennillo E, Bain J, Li Z, Sun X, Ly K, et al. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022;132: pubmed publisher
  5. Li B, Lian M, Li Y, Qian Q, Zhang J, Liu Q, et al. Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune Hepatitis. Front Immunol. 2021;12:732102 pubmed publisher
  6. Liang H, Matei N, McBride D, Xu Y, Zhou Z, Tang J, et al. TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. J Neuroinflammation. 2021;18:40 pubmed publisher
  7. Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
  8. Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed publisher
  9. Sheng L, Zhang J, Li L, Xie X, Wen X, Cheng K. Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers Through an Intrinsic Apoptosis Pathway. Biomolecules. 2020;10: pubmed publisher
  10. Jonczyk A, Piotrowska Tomala K, Skarzynski D. Effects of prostaglandin F2α (PGF2α) on cell-death pathways in the bovine corpus luteum (CL). BMC Vet Res. 2019;15:416 pubmed publisher
  11. Vredevoogd D, Kuilman T, Ligtenberg M, Boshuizen J, Stecker K, de Bruijn B, et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019;178:585-599.e15 pubmed publisher
  12. Liu X, Zhao P, Wang X, Wang L, Zhu Y, Song Y, et al. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. J Exp Clin Cancer Res. 2019;38:184 pubmed publisher
  13. Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed publisher
  14. Peltzer N, Darding M, Montinaro A, Dráber P, Draberova H, Kupka S, et al. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018;557:112-117 pubmed publisher
  15. Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher
  16. Lang M, Jenkins S, Balzano P, Owoyele A, Patel A, Bamezai A. Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4+ T-cell lines. Immun Inflamm Dis. 2017;5:448-460 pubmed publisher
  17. Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  18. Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13:739-753 pubmed publisher
  19. Lin J, Kumari S, Kim C, Van T, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124-128 pubmed publisher
  20. Pu X, Storr S, Zhang Y, Rakha E, Green A, Ellis I, et al. Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival. Apoptosis. 2017;22:357-368 pubmed publisher
  21. Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  22. Strilic B, Yang L, Albarrán Juárez J, Wachsmuth L, Han K, Müller U, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016;536:215-8 pubmed
  23. Al Lamki R, Lu W, Manalo P, Wang J, Warren A, Tolkovsky A, et al. Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis. Cell Death Dis. 2016;7:e2287 pubmed publisher
  24. Song J, Wang Y, Teng M, Zhang S, Yin M, Lu J, et al. Cordyceps militaris induces tumor cell death via the caspase?dependent mitochondrial pathway in HepG2 and MCF?7 cells. Mol Med Rep. 2016;13:5132-40 pubmed publisher
  25. Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher
  26. Seifert L, Werba G, Tiwari S, Giao Ly N, Alothman S, Alqunaibit D, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532:245-9 pubmed publisher
  27. Martin B, Wang C, Zhang C, Kang Z, Gulen M, Zepp J, et al. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. 2016;17:583-92 pubmed publisher
  28. Orme M, Liccardi G, Moderau N, Feltham R, Wicky John S, Tenev T, et al. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nat Commun. 2016;7:10972 pubmed publisher
  29. Wu M, Ai W, Chen L, Zhao S, Liu E. Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice. Int J Mol Med. 2016;37:565-74 pubmed publisher
  30. Oh Y, Yue P, Wang D, Tong J, Chen Z, Khuri F, et al. Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling. Oncotarget. 2015;6:41324-38 pubmed publisher
  31. Campo Verde Arboccó F, Sasso C, Actis E, Carón R, Hapon M, Jahn G. Hypothyroidism advances mammary involution in lactating rats through inhibition of PRL signaling and induction of LIF/STAT3 mRNAs. Mol Cell Endocrinol. 2016;419:18-28 pubmed publisher
  32. Mao D, Che J, Han S, Zhao H, Zhu Y, Zhu H. RNAi-mediated knockdown of the CLN3 gene inhibits proliferation and promotes apoptosis in drug-resistant ovarian cancer cells. Mol Med Rep. 2015;12:6635-41 pubmed publisher
  33. Stefanowicz Hajduk J, Bartoszewski R, Bartoszewska S, Kochan K, Adamska A, Kosiński I, et al. Pennogenyl Saponins from Paris quadrifolia L. Induce Extrinsic and Intrinsic Pathway of Apoptosis in Human Cervical Cancer HeLa Cells. PLoS ONE. 2015;10:e0135993 pubmed publisher
  34. Cheng C, Lin J, Tang N, Kao S, Hsieh C. Electroacupuncture at different frequencies (5Hz and 25Hz) ameliorates cerebral ischemia-reperfusion injury in rats: possible involvement of p38 MAPK-mediated anti-apoptotic signaling pathways. BMC Complement Altern Med. 2015;15:241 pubmed publisher
  35. Wang Y, Li Q, Wei X, Xu J, Chen Q, Song S, et al. Targeted knockout of TNF-? by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats. Mol Med Rep. 2015;12:4389-4395 pubmed publisher
  36. Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed publisher
  37. Deutsch M, Graffeo C, Rokosh R, Pansari M, Ochi A, Levie E, et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 2015;6:e1759 pubmed publisher
  38. Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher
  39. ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, et al. Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress. Mol Biol Cell. 2015;26:1947-56 pubmed publisher
  40. Pooya S, Liu X, Kumar V, Anderson J, Imai F, Zhang W, et al. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nat Commun. 2014;5:4993 pubmed publisher
  41. Dirks Naylor A, Kouzi S, Bero J, Tran N, Yang S, Mabolo R. Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment. World J Biol Chem. 2014;5:377-86 pubmed publisher
  42. Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed publisher
  43. Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher