This is a Validated Antibody Database (VAD) review about rat Xrcc1, based on 15 published articles (read how Labome selects the articles), using Xrcc1 antibody in all methods. It is aimed to help Labome visitors find the most suited Xrcc1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Xrcc1 synonym: DNA repair protein XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; x-ray repair cross-complementing group 1 protein

Abcam
rabbit monoclonal (EPR4389(2))
  • immunohistochemistry - paraffin section; human; loading ...; fig s7
  • western blot; human; loading ...; fig s2b
Abcam Xrcc1 antibody (Abcam, ab134056) was used in immunohistochemistry - paraffin section on human samples (fig s7) and in western blot on human samples (fig s2b). Nucleic Acids Res (2018) ncbi
mouse monoclonal (33-2-5)
  • western blot; human; 1:200
Abcam Xrcc1 antibody (Abcam, ab1838) was used in western blot on human samples at 1:200. Genome Biol (2018) ncbi
mouse monoclonal (33-2-5)
  • immunocytochemistry; human; loading ...; fig 2
  • western blot; human; loading ...; fig 1
Abcam Xrcc1 antibody (Abcam, ab1838) was used in immunocytochemistry on human samples (fig 2) and in western blot on human samples (fig 1). Nucleic Acids Res (2017) ncbi
rabbit monoclonal (EPR4389(2))
  • immunocytochemistry; human; 1:1000; loading ...; fig 1a
In order to assess the effect of the ROS burst on DNA integrity, cell death and differentiation potential of monocytes, Abcam Xrcc1 antibody (Abcam, ab134056) was used in immunocytochemistry on human samples at 1:1000 (fig 1a). PLoS ONE (2017) ncbi
mouse monoclonal (33-2-5)
  • immunocytochemistry; mouse; 1:50
Abcam Xrcc1 antibody (Abcam, ab1838) was used in immunocytochemistry on mouse samples at 1:50. DNA Repair (Amst) (2015) ncbi
mouse monoclonal (33-2-5)
  • immunocytochemistry; human; fig 5
  • western blot; human; fig s1
Abcam Xrcc1 antibody (Abcam, ab1838-250) was used in immunocytochemistry on human samples (fig 5) and in western blot on human samples (fig s1). Nucleic Acids Res (2015) ncbi
mouse monoclonal (33-2-5)
  • western blot; human; 1:500; fig s1d
In order to investigate the role of protein stability in the choice of DNA repair mechanism, Abcam Xrcc1 antibody (Abcam, 33-2-5) was used in western blot on human samples at 1:500 (fig s1d). Nat Commun (2014) ncbi
rabbit monoclonal (EPR4389(2))
  • western blot; mouse; 1:2000
Abcam Xrcc1 antibody (Epitomics, 3631-1) was used in western blot on mouse samples at 1:2000. PLoS ONE (2014) ncbi
mouse monoclonal (33-2-5)
  • western blot; human
Abcam Xrcc1 antibody (Abcam, ab1838) was used in western blot on human samples . Cancer Res (2014) ncbi
mouse monoclonal (33-2-5)
  • immunocytochemistry; mouse; 1:50
In order to study the effect of cellular XRCC1 oxidation on PARP-mediated DNA damage responses, Abcam Xrcc1 antibody (Abcam, ab1838) was used in immunocytochemistry on mouse samples at 1:50. DNA Repair (Amst) (2013) ncbi
mouse monoclonal (33-2-5)
  • western blot; human; fig 4
Abcam Xrcc1 antibody (Abcam, 33-2-5) was used in western blot on human samples (fig 4). Mutat Res (2011) ncbi
Invitrogen
mouse monoclonal (33-2-5)
  • western blot; mouse
Invitrogen Xrcc1 antibody (Thermo Fisher Scientific, 33-2-5) was used in western blot on mouse samples . DNA Repair (Amst) (2015) ncbi
mouse monoclonal (33-2-5)
  • western blot; mouse
In order to investigate the effect of base excision repair defects on PARP inhibition, Invitrogen Xrcc1 antibody (Thermo Fisher Scientific, 33-2-5) was used in western blot on mouse samples . Mol Cancer Res (2014) ncbi
mouse monoclonal (33-2-5)
  • western blot; mouse
In order to study the effect of cellular XRCC1 oxidation on PARP-mediated DNA damage responses, Invitrogen Xrcc1 antibody (Thermo Fisher, 33-2-5) was used in western blot on mouse samples . DNA Repair (Amst) (2013) ncbi
mouse monoclonal (33-2-5)
  • western blot; human; fig s2
In order to study the functional significance of the DNA polymerase-beta interaction with BRCA1, Invitrogen Xrcc1 antibody (Thermo Fisher Scientific, 33-2-5) was used in western blot on human samples (fig s2). PLoS ONE (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (33-2-5)
  • immunocytochemistry; human; fig 7
Santa Cruz Biotechnology Xrcc1 antibody (Santa Cruz, sc-56254) was used in immunocytochemistry on human samples (fig 7). Nucleic Acids Res (2016) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; loading ...; fig 4a
Sigma-Aldrich Xrcc1 antibody (SIGMA, X0629) was used in western blot on human samples (fig 4a). Sci Rep (2016) ncbi
Articles Reviewed
  1. Li M, Yang X, LU X, Dai N, Zhang S, Cheng Y, et al. APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res. 2018;46:5664-5677 pubmed publisher
  2. Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018;19:37 pubmed publisher
  3. Bj Rås K, Sousa M, Sharma A, Fonseca D, S Gaard C, Bj Rås M, et al. Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Nucleic Acids Res. 2017;45:8291-8301 pubmed publisher
  4. Ponath V, Kaina B. Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans. PLoS ONE. 2017;12:e0170347 pubmed publisher
  5. Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet Robinet E, Salles B, et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep. 2016;6:36022 pubmed publisher
  6. Yu Z, Huang Y, Shieh S. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic Acids Res. 2016;44:1133-50 pubmed publisher
  7. Horton J, Gassman N, Dunigan B, Stefanick D, Wilson S. DNA polymerase β-dependent cell survival independent of XRCC1 expression. DNA Repair (Amst). 2015;26:23-9 pubmed publisher
  8. Abdou I, Poirier G, Hendzel M, Weinfeld M. DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair. Nucleic Acids Res. 2015;43:875-92 pubmed publisher
  9. Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun. 2014;5:5513 pubmed publisher
  10. Horton J, Stefanick D, Prasad R, Gassman N, Kedar P, Wilson S. Base excision repair defects invoke hypersensitivity to PARP inhibition. Mol Cancer Res. 2014;12:1128-39 pubmed publisher
  11. FAYZULLINA S, Martin L. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PLoS ONE. 2014;9:e93329 pubmed publisher
  12. Prensner J, Chen W, Iyer M, Cao Q, Ma T, Han S, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 2014;74:1651-60 pubmed publisher
  13. Horton J, Stefanick D, Gassman N, Williams J, Gabel S, Cuneo M, et al. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst). 2013;12:774-85 pubmed publisher
  14. Masaoka A, Gassman N, Horton J, Kedar P, Witt K, Hobbs C, et al. Interaction between DNA Polymerase ? and BRCA1. PLoS ONE. 2013;8:e66801 pubmed publisher
  15. Ebert F, Weiss A, Bültemeyer M, Hamann I, Hartwig A, Schwerdtle T. Arsenicals affect base excision repair by several mechanisms. Mutat Res. 2011;715:32-41 pubmed publisher