This is a Validated Antibody Database (VAD) review about rat Tek, based on 4 published articles (read how Labome selects the articles), using Tek antibody in all methods. It is aimed to help Labome visitors find the most suited Tek antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Tek synonym: Tie-2; Tie2; angiopoietin-1 receptor; TEK tyrosine kinase, endothelial; endothelial-specific receptor tyrosine kinase; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2

Knockout validation
R&D Systems
goat polyclonal
  • immunohistochemistry - frozen section; human; loading ...; fig 2a
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1b
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1a
R&D Systems Tek antibody (R&D Systems, AF762) was used in immunohistochemistry - frozen section on human samples (fig 2a), in immunohistochemistry knockout validation on mouse samples (fig s1b) and in immunohistochemistry - frozen section on mouse samples (fig 1a). J Clin Invest (2017) ncbi
R&D Systems
goat polyclonal
  • immunohistochemistry - frozen section; human; loading ...; fig 2a
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1b
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1a
R&D Systems Tek antibody (R&D Systems, AF762) was used in immunohistochemistry - frozen section on human samples (fig 2a), in immunohistochemistry knockout validation on mouse samples (fig s1b) and in immunohistochemistry - frozen section on mouse samples (fig 1a). J Clin Invest (2017) ncbi
goat polyclonal
  • immunohistochemistry - free floating section; mouse; 1:50; fig 9
  • western blot; mouse; 1:500; fig 8
In order to determine the rescue of VE-PTP-dependent restoration of Tie2 signaling from angiopoietin-2-induced blood-brain barrier compromise and increased stroke size, R&D Systems Tek antibody (R&D Systems, AF762) was used in immunohistochemistry - free floating section on mouse samples at 1:50 (fig 9) and in western blot on mouse samples at 1:500 (fig 8). Acta Neuropathol (2016) ncbi
goat polyclonal
  • immunohistochemistry; mouse; fig 5
In order to determine the roles of Sox7, Sox17, and Sox18 in the developing and mature mouse vasculature, R&D Systems Tek antibody (R&D Systems, AF762) was used in immunohistochemistry on mouse samples (fig 5). PLoS ONE (2015) ncbi
Abcam
rabbit polyclonal
  • western blot; human; loading ...; fig s1c
In order to study the role of distinct RNA transcriptome patterns in angiogenesis in Tie2-expressing monocytes, Abcam Tek antibody (Abcam, ab137786) was used in western blot on human samples (fig s1c). Gene (2016) ncbi
Articles Reviewed
  1. Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
  2. Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, et al. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol. 2016;131:753-73 pubmed publisher
  3. Wang X, Dai Z, Wu X, Wang K, Wang X. Distinct RNA transcriptome patterns are potentially associated with angiogenesis in Tie2-expressing monocytes. Gene. 2016;580:1-7 pubmed publisher
  4. Zhou Y, Williams J, Smallwood P, Nathans J. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE. 2015;10:e0143650 pubmed publisher