This is a Validated Antibody Database (VAD) review about rat TACE, based on 14 published articles (read how Labome selects the articles), using TACE antibody in all methods. It is aimed to help Labome visitors find the most suited TACE antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TACE synonym: TACE; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; TNF-alpha-converting enzyme; a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)

Knockout validation
Abcam
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; loading ...; fig 2
Abcam TACE antibody (Abcam, ab39163) was used in immunohistochemistry knockout validation on mouse samples (fig 2). Hypertension (2016) ncbi
Abcam
rabbit polyclonal
  • western blot; human; 1:1000; fig 1h
Abcam TACE antibody (Abcam, ab39162) was used in western blot on human samples at 1:1000 (fig 1h). Nat Commun (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 5c
In order to investigate the role of FURIN in LysM positive myeloid cells in vivo, Abcam TACE antibody (Abcam, ab39162) was used in western blot on mouse samples (fig 5c). Oncotarget (2016) ncbi
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; loading ...; fig 2
Abcam TACE antibody (Abcam, ab39163) was used in immunohistochemistry knockout validation on mouse samples (fig 2). Hypertension (2016) ncbi
rabbit polyclonal
  • immunoprecipitation; hamsters; fig 2
  • western blot; hamsters; fig 2
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, Abcam TACE antibody (Abcam, ab75609) was used in immunoprecipitation on hamsters samples (fig 2) and in western blot on hamsters samples (fig 2). J Cell Biol (2015) ncbi
rabbit polyclonal
  • western blot; human
In order to study the role of ADAM17 in cellular senescence and senescence secretome, Abcam TACE antibody (Abcam, ab39162) was used in western blot on human samples . Breast Cancer Res (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 3
  • western blot; human; fig 3
Abcam TACE antibody (Abcam, ab2051) was used in western blot on mouse samples (fig 3) and in western blot on human samples (fig 3). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1100
Abcam TACE antibody (Abcam, ab2051) was used in western blot on mouse samples at 1:1100. Proc Natl Acad Sci U S A (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:1000
  • western blot; human; 1:1000
In order to examine the importance of iron in relation to amyloid-beta production within the retina, Abcam TACE antibody (Abcam, ab2051) was used in immunohistochemistry - paraffin section on human samples at 1:1000 and in western blot on human samples at 1:1000. Exp Eye Res (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:2000
In order to study the role of iRhom2 in the regulation of EGF receptor signalling in mice, Abcam TACE antibody (Abcam, ab39161) was used in western blot on human samples at 1:2000. Biol Open (2014) ncbi
rabbit polyclonal
  • flow cytometry; mouse
In order to study the mechanism for the effect of HMGB1 on myeloid-derived suppressor cells, Abcam TACE antibody (Abcam, ab2051) was used in flow cytometry on mouse samples . Cancer Res (2014) ncbi
rabbit polyclonal
  • western blot; human
Abcam TACE antibody (Abcam, ab39162) was used in western blot on human samples . Int J Biol Sci (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam TACE antibody (Abcam, ab2051) was used in western blot on mouse samples . Biochim Biophys Acta (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:3000
Abcam TACE antibody (Abcam, 2051) was used in western blot on human samples at 1:3000. J Biol Chem (2013) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; 1:1000; fig 7
Sigma-Aldrich TACE antibody (Sigma-aldrich, SAB3500367) was used in western blot on human samples at 1:1000 (fig 7). PLoS Pathog (2015) ncbi
Articles Reviewed
  1. Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  2. Cordova Z, Grönholm A, Kytölä V, Taverniti V, Hämäläinen S, Aittomäki S, et al. Myeloid cell expressed proprotein convertase FURIN attenuates inflammation. Oncotarget. 2016;7:54392-54404 pubmed publisher
  3. Takayanagi T, Forrester S, Kawai T, Obama T, Tsuji T, Elliott K, et al. Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Hypertension. 2016;68:949-955 pubmed publisher
  4. Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  5. Morancho B, Martínez Barriocanal Ã, Villanueva J, Arribas J. Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence. Breast Cancer Res. 2015;17:106 pubmed publisher
  6. Dombernowsky S, Samsøe Petersen J, Petersen C, Instrell R, Hedegaard A, Thomas L, et al. The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. Nat Commun. 2015;6:7518 pubmed publisher
  7. Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher
  8. Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher
  9. Guo L, Alekseev O, Li Y, Song Y, Dunaief J. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res. 2014;129:31-7 pubmed publisher
  10. Siggs O, Grieve A, Xu H, Bambrough P, Christova Y, Freeman M. Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice. Biol Open. 2014;3:1151-7 pubmed publisher
  11. Parker K, Sinha P, Horn L, Clements V, Yang H, Li J, et al. HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells. Cancer Res. 2014;74:5723-33 pubmed publisher
  12. Huang Y, Benaich N, Tape C, Kwok H, Murphy G. Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation. Int J Biol Sci. 2014;10:702-14 pubmed publisher
  13. Fiaturi N, Ritzkat A, Dammann C, Castellot J, Nielsen H. Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation. Biochim Biophys Acta. 2014;1843:797-805 pubmed publisher
  14. Woods N, Padmanabhan J. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. J Biol Chem. 2013;288:30114-24 pubmed publisher