This is a Validated Antibody Database (VAD) review about rat Socs3, based on 27 published articles (read how Labome selects the articles), using Socs3 antibody in all methods. It is aimed to help Labome visitors find the most suited Socs3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Socs3 synonym: Cish3; Socs-3; Ssi-3

Knockout validation
Abcam
domestic rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4d
In order to study the roles of STAT3 and SOCS3 in NG2 cell proliferation and differentiation after spinal cord injury, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot knockout validation on mouse samples at 1:1000 (fig 4d). Neurobiol Dis (2016) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 5c, 6a, 8d
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples at 1:1000 (fig 5c, 6a, 8d). Aging (Albany NY) (2021) ncbi
mouse monoclonal (SO1)
  • immunocytochemistry; mouse; loading ...; fig 1b
  • western blot; mouse; 1:1000; loading ...; fig 1a
Abcam Socs3 antibody (Abcam, ab14939) was used in immunocytochemistry on mouse samples (fig 1b) and in western blot on mouse samples at 1:1000 (fig 1a). Neuropsychiatr Dis Treat (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5a
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples (fig 5a). Oncogene (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 5
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on mouse samples (fig 5). Int J Obes (Lond) (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 3g
In order to report that TrkC contributes to tumorigenicity, metastasis, and self-renewal traits of metastatic breast cancer, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples (fig 3g). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • flow cytometry; mouse; loading ...; fig 5d
Abcam Socs3 antibody (Abcam, ab16030) was used in flow cytometry on mouse samples (fig 5d). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; rat; fig 3
Abcam Socs3 antibody (abcam, ab16030) was used in western blot on rat samples (fig 3). Int J Mol Sci (2016) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 4d
In order to study the roles of STAT3 and SOCS3 in NG2 cell proliferation and differentiation after spinal cord injury, Abcam Socs3 antibody (Abcam, ab16030) was used in western blot knockout validation on mouse samples at 1:1000 (fig 4d). Neurobiol Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 5b
Abcam Socs3 antibody (AbCam, AB16030) was used in western blot on human samples (fig 5b). Int J Obes (Lond) (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig s6
Abcam Socs3 antibody (Abcam, ab16030) was used in western blot on human samples (fig s6). Leukemia (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (SO1)
  • immunohistochemistry - paraffin section; human; 1:50; tbl 1
In order to examine the oncogenic function of signal transducer and activator of transcription 1 in malignant pleural mesothelioma, Santa Cruz Biotechnology Socs3 antibody (Santa Cruz, sc-51699) was used in immunohistochemistry - paraffin section on human samples at 1:50 (tbl 1). Pathol Oncol Res (2017) ncbi
mouse monoclonal (SO1)
  • western blot; human; fig 5
Santa Cruz Biotechnology Socs3 antibody (Santa Cruz, sc51699) was used in western blot on human samples (fig 5). BMC Genomics (2015) ncbi
mouse monoclonal (SO1)
  • western blot; human; 1:200
Santa Cruz Biotechnology Socs3 antibody (Santa Cruz, sc-51699) was used in western blot on human samples at 1:200. Cell Death Dis (2014) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 2c
Cell Signaling Technology Socs3 antibody (Cell Signalling, 2923) was used in immunohistochemistry on mouse samples (fig 2c). EBioMedicine (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 6b
Cell Signaling Technology Socs3 antibody (Cell signaling, 2923) was used in western blot on mouse samples at 1:500 (fig 6b). J Lipid Res (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s8b
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig s8b). Proc Natl Acad Sci U S A (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 2c
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples (fig 2c). Nature (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s5d
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923S) was used in western blot on mouse samples (fig s5d). J Clin Invest (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5a
Cell Signaling Technology Socs3 antibody (Cell signaling, 2923) was used in western blot on mouse samples (fig 5a). Mol Biol Cell (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig st2
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig st2). Brain Behav Immun (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3a
In order to show that the MEK1/2 pathway is a key regulator of macrophage reparative properties, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2923) was used in western blot on mouse samples (fig 3a). J Immunol (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; fig s6a
In order to study the mechanisms driving uterine leiomyoma growth and survival via aberrant activation of AKT, Cell Signaling Technology Socs3 antibody (Cell signaling, 2932) was used in western blot on human samples (fig s6a). Sci Adv (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4
In order to investigate the effect of a microtubule inhibitor, MPT0B098, on STAT3 signaling in oral squamous cell carcinoma, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on human samples (fig 4). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 4
Cell Signaling Technology Socs3 antibody (Cell signaling, 2923) was used in western blot on mouse samples at 1:1000 (fig 4). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; bovine; 1:1000; fig 2
In order to study how the IL6R/STAT3 signaling pathway regulates IL-8 production by primary endometrial cells in response to lipopolysaccharide treatment, Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on bovine samples at 1:1000 (fig 2). Mucosal Immunol (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s3b
Cell Signaling Technology Socs3 antibody (Cell Signaling, 2932) was used in western blot on mouse samples (fig s3b). Cell Death Differ (2016) ncbi
Articles Reviewed
  1. Wang T, Zhou P, Xie X, Tomita Y, Cho S, Tsirukis D, et al. Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3. EBioMedicine. 2021;73:103632 pubmed publisher
  2. Berger C, Heyne H, Heiland T, Dommel S, Höfling C, Guiu Jurado E, et al. A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice. J Lipid Res. 2021;62:100105 pubmed publisher
  3. Liu W, Long Q, Zhang W, Zeng D, Hu B, Liu S, et al. miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis. Aging (Albany NY). 2021;13:19760-19775 pubmed publisher
  4. Liang E, Li X, Fu W, Zhao C, Yang B, Yang Z. COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein. Neuropsychiatr Dis Treat. 2021;17:1217-1227 pubmed publisher
  5. Lee E, Ouzounova M, Piranlioglu R, Ma M, Guzel M, Marasco D, et al. The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20. Oncogene. 2019;38:469-482 pubmed publisher
  6. Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, et al. Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proc Natl Acad Sci U S A. 2018;115:E2801-E2810 pubmed publisher
  7. Shen Q, Zhang Q, Shi Y, Shi Q, Jiang Y, Gu Y, et al. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature. 2018;554:123-127 pubmed publisher
  8. Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
  9. Chaudhari A, Gupta R, Patel S, Velingkaar N, Kondratov R. Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. Mol Biol Cell. 2017;28:834-842 pubmed publisher
  10. Liu W, Liu J, Xia J, Xue X, Wang H, Qi Z, et al. Leptin receptor knockout-induced depression-like behaviors and attenuated antidepressant effects of exercise are associated with STAT3/SOCS3 signaling. Brain Behav Immun. 2017;61:297-305 pubmed publisher
  11. Long M, Eddy W, Gong K, Lovelace Macon L, McMahan R, Charron J, et al. MEK1/2 Inhibition Promotes Macrophage Reparative Properties. J Immunol. 2017;198:862-872 pubmed publisher
  12. Arzt L, Halbwedl I, Gogg Kamerer M, Popper H. Signal Transducer and Activator of Transcription 1 (STAT1) Knock-down Induces Apoptosis in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2017;23:595-605 pubmed publisher
  13. Hwang M, Go Y, Park J, Shin S, Song S, Oh B, et al. Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance. Int J Obes (Lond). 2017;41:279-288 pubmed publisher
  14. Vidimar V, Gius D, Chakravarti D, Bulun S, Wei J, Kim J. Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2016;2:e1601132 pubmed
  15. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  16. Kim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisher
  17. Chen W, Gao L, Wang J, Wang Y, Dong Z, Zhao J, et al. Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes. Oncotarget. 2016;7:57485-57497 pubmed publisher
  18. Peng H, Cheng Y, Hsu Y, Wu G, Kuo C, Liou J, et al. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0158440 pubmed publisher
  19. Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  20. Huang Y, Chen C, Tang K, Sheen J, Tiao M, Tain Y, et al. Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect. Int J Mol Sci. 2016;17:369 pubmed publisher
  21. Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
  22. Hackett A, Lee D, Dawood A, Rodriguez M, Funk L, Tsoulfas P, et al. STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. Neurobiol Dis. 2016;89:10-22 pubmed publisher
  23. Trierweiler C, Hockenjos B, Zatloukal K, Thimme R, Blum H, Wagner E, et al. The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice. Cell Death Differ. 2016;23:576-82 pubmed publisher
  24. Singh P, Sharma P, Sahakyan K, Davison D, Sert Kuniyoshi F, Romero Corral A, et al. Differential effects of leptin on adiponectin expression with weight gain versus obesity. Int J Obes (Lond). 2016;40:266-74 pubmed publisher
  25. Roncero A, López Nieva P, Cobos Fernández M, Villa Morales M, González Sánchez L, López Lorenzo J, et al. Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development. Leukemia. 2016;30:94-103 pubmed publisher
  26. Masotti A, Donninelli G, Da Sacco L, Varano B, Del Cornò M, Gessani S. HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation. BMC Genomics. 2015;16:480 pubmed publisher
  27. Mathieu M, Miles A, Ahmad M, Buczek M, Pockley A, Rees R, et al. The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. Cell Death Dis. 2014;5:e1061 pubmed publisher