This is a Validated Antibody Database (VAD) review about rat Ripk2, based on 8 published articles (read how Labome selects the articles), using Ripk2 antibody in all methods. It is aimed to help Labome visitors find the most suited Ripk2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ripk2 synonym: receptor-interacting serine/threonine-protein kinase 2; receptor (TNFRSF)-interacting serine-threonine kinase 2

Knockout validation
Abnova
mouse monoclonal (6F7)
  • western blot; human; loading ...; fig 5c
  • western blot knockout validation; mouse; loading ...; fig 5a
In order to find that LRRK2 regulates Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway, Abnova Ripk2 antibody (Abnova, H0000876-M02) was used in western blot on human samples (fig 5c) and in western blot knockout validation on mouse samples (fig 5a). Protein Cell (2017) ncbi
Abnova
mouse monoclonal (6F7)
  • western blot; human; loading ...; fig 5c
  • western blot knockout validation; mouse; loading ...; fig 5a
In order to find that LRRK2 regulates Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway, Abnova Ripk2 antibody (Abnova, H0000876-M02) was used in western blot on human samples (fig 5c) and in western blot knockout validation on mouse samples (fig 5a). Protein Cell (2017) ncbi
Abcam
rabbit polyclonal
  • western blot; human; fig 5
Abcam Ripk2 antibody (Abcam, ab8428) was used in western blot on human samples (fig 5). Biochem Biophys Res Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000
Abcam Ripk2 antibody (Abcam, ab8428) was used in western blot on human samples at 1:1000. Mol Immunol (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (25)
  • immunocytochemistry; human
  • western blot; human
Santa Cruz Biotechnology Ripk2 antibody (Santa Cruz Biotech, sc-136059) was used in immunocytochemistry on human samples and in western blot on human samples . Breast Cancer Res (2014) ncbi
Enzo Life Sciences
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3d
Enzo Life Sciences Ripk2 antibody (Enzo Life Sciences, ADI-AAP-460) was used in western blot on mouse samples (fig 3d). Front Pharmacol (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (D10B11)
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology Ripk2 antibody (Cell signaling technology, 4142) was used in western blot on mouse samples at 1:1000 (fig 4c). Nat Commun (2018) ncbi
rabbit monoclonal (D10B11)
  • western blot; mouse
In order to assess the role of receptor-interacting protein 2 in VEGF signalling and myocardial ischaemia/reperfusion injury, Cell Signaling Technology Ripk2 antibody (Cell Signalling Technologies, 4142) was used in western blot on mouse samples . Cardiovasc Res (2015) ncbi
rabbit monoclonal (D10B11)
  • western blot; human
Cell Signaling Technology Ripk2 antibody (Cell Signaling Technology, D10B11) was used in western blot on human samples . J Immunol (2014) ncbi
Articles Reviewed
  1. Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher
  2. Pediaditakis I, Kourgiantaki A, Prousis K, Potamitis C, Xanthopoulos K, Zervou M, et al. BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis. Front Pharmacol. 2016;7:512 pubmed publisher
  3. Yan R, Liu Z. LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. Protein Cell. 2017;8:55-66 pubmed publisher
  4. Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
  5. Andersson L, Scharin Täng M, Lundqvist A, Lindbom M, Mardani I, Fogelstrand P, et al. Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia. Cardiovasc Res. 2015;107:478-86 pubmed publisher
  6. Wu J, Zhang Y, Xin Z, Wu X. The crosstalk between TLR2 and NOD2 in Aspergillus fumigatus keratitis. Mol Immunol. 2015;64:235-43 pubmed publisher
  7. Heymann M, Winkler S, Luksch H, Flecks S, Franke M, Ruß S, et al. Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-?B signaling. J Immunol. 2014;192:4379-85 pubmed publisher
  8. Singel S, Batten K, Cornelius C, Jia G, Fasciani G, Barron S, et al. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res. 2014;16:R28 pubmed publisher