This is a Validated Antibody Database (VAD) review about rat Rab7a, based on 83 published articles (read how Labome selects the articles), using Rab7a antibody in all methods. It is aimed to help Labome visitors find the most suited Rab7a antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Rab7a synonym: Rab7
Knockout validation
Abcam domestic rabbit monoclonal (EPR7589) |
| Abcam Rab7a antibody (Abcam, EPR7589) was used in immunocytochemistry knockout validation on human samples at 1:100 (fig 1b) and in western blot on human samples at 1:1000 (fig s4d). EMBO J (2018) ncbi |
Abcam domestic rabbit monoclonal (EPR7589) |
| In order to report a B cell-intrinsic role for Rab7, Abcam Rab7a antibody (Abcam, ab137029) was used in immunocytochemistry knockout validation on mouse samples (fig 2D) and in western blot knockout validation on mouse samples (fig 2C). J Immunol (2015) ncbi |
Cell Signaling Technology domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry knockout validation on mouse samples (fig 1), in western blot knockout validation on mouse samples (fig 1) and in flow cytometry on mouse samples (fig 1). Autophagy (2013) ncbi |
Abcam
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in western blot on human samples at 1:1000 (fig 1d). elife (2019) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, Rab7-117) was used in immunocytochemistry on human samples (fig 4m). Front Immunol (2018) ncbi |
domestic rabbit monoclonal (EPR7589) |
| Abcam Rab7a antibody (Abcam, ab137029) was used in ELISA on mouse samples at 1:1000 (fig 3c). Nat Cell Biol (2019) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on mouse samples (fig s10e). Science (2018) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunohistochemistry on mouse samples at 1:2000 (fig s5). J Clin Invest (2018) ncbi |
domestic rabbit monoclonal (EPR7589) |
| Abcam Rab7a antibody (Abcam, EPR7589) was used in immunocytochemistry knockout validation on human samples at 1:100 (fig 1b) and in western blot on human samples at 1:1000 (fig s4d). EMBO J (2018) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, 50533) was used in western blot on rat samples at 1:500 (fig 5e). J Cell Biol (2017) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on swine samples (fig 3d). Biochim Biophys Acta Mol Cell Biol Lipids (2017) ncbi |
mouse monoclonal (Rab7-117) |
| In order to study the role of CD146 in the formation and retention of macrophage foam cells, Abcam Rab7a antibody (Abcam, ab50533) was used in western blot on mouse samples (fig 8). Cell Res (2017) ncbi |
domestic rabbit monoclonal (EPR7588(B)) |
| Abcam Rab7a antibody (Abcam, ab126712) was used in immunohistochemistry - frozen section on rat samples (fig 5). PLoS ONE (2016) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on mouse samples (fig 3g). Oncotarget (2016) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunohistochemistry on human samples at 1:100 (fig 4e). J Immunol (2016) ncbi |
domestic rabbit monoclonal (EPR7589) |
| Abcam Rab7a antibody (Abcam, Ab137029) was used in western blot on mouse samples (fig 1). EMBO J (2016) ncbi |
mouse monoclonal (Rab7-117) |
| In order to mediate direct uptake of RNA by lysosomes by lysosomal putative RNA transporter SIDT2, Abcam Rab7a antibody (Abcam, ab50533) was used in western blot on mouse samples (fig 1). Autophagy (2016) ncbi |
mouse monoclonal (Rab7-117) |
| In order to study how importation of copper into cells is regulated, Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on human samples at 1:1000 (fig 4). J Cell Sci (2016) ncbi |
mouse monoclonal (Rab7-117) |
| In order to research the involvement of miRNA in cholesterol homeostasis, Abcam Rab7a antibody (Abcam, 50533) was used in immunocytochemistry on human samples (fig 4). Arterioscler Thromb Vasc Biol (2016) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on mouse samples at 1:200-1:500 (fig 7). PLoS Genet (2015) ncbi |
mouse monoclonal (Rab7-117) |
| In order to assess the effects of an autophagy inducer on col6a1 knock out mice, Abcam Rab7a antibody (Abcam, ab50533) was used in western blot on mouse samples . Autophagy (2015) ncbi |
domestic rabbit monoclonal (EPR7589) |
| Abcam Rab7a antibody (Abcam, ab137029) was used in immunocytochemistry on human samples at 1:300 (fig 2) and in western blot on human samples at 1:1000 (fig 4). Nat Commun (2015) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, Rab7-117) was used in immunohistochemistry - paraffin section on mouse samples . Front Cell Neurosci (2015) ncbi |
domestic rabbit monoclonal (EPR7589) |
| In order to report a B cell-intrinsic role for Rab7, Abcam Rab7a antibody (Abcam, ab137029) was used in immunocytochemistry knockout validation on mouse samples (fig 2D) and in western blot knockout validation on mouse samples (fig 2C). J Immunol (2015) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunoprecipitation on mouse samples , in western blot on mouse samples , in immunoprecipitation on rat samples and in western blot on rat samples . J Neurosci (2015) ncbi |
mouse monoclonal (Rab7-117) |
| In order to show that C9ORF72 regulates endosomal trafficking, Abcam Rab7a antibody (Abcam, ab50533) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 4a), in immunocytochemistry on mouse samples at 1:50 (fig 2a) and in western blot on mouse samples at 1:500 (fig 2b). Hum Mol Genet (2014) ncbi |
mouse monoclonal (Rab7-117) |
| In order to study the interaction of the TIP47 lipid droplet-binding protein with HCV NS5A and the role of this interaction in the regulation of viral RNA replication, Abcam Rab7a antibody (Abcam, ab50533) was used in western blot on human samples (fig 3). PLoS Pathog (2013) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on human samples . FASEB J (2013) ncbi |
mouse monoclonal (Rab7-117) |
| Abcam Rab7a antibody (Abcam, ab50533) was used in immunocytochemistry on dogs samples and in western blot on dogs samples . J Biol Chem (2012) ncbi |
Santa Cruz Biotechnology
mouse monoclonal (B-3) |
| In order to investigate Rab7 and Arl8b crosstalk, Santa Cruz Biotechnology Rab7a antibody (Santa Cruz, sc-376362) was used in immunocytochemistry on human samples (fig 4f) and in western blot on human samples (fig 5f). J Cell Biol (2017) ncbi |
mouse monoclonal (B-3) |
| Santa Cruz Biotechnology Rab7a antibody (SantaCruz, sc-376362) was used in western blot on human samples at 1:800 (fig 7f). EMBO Mol Med (2017) ncbi |
mouse monoclonal (B-3) |
| Santa Cruz Biotechnology Rab7a antibody (Santa Cruz Biotechnology, sc-376362) was used in blocking or activating experiments on mouse samples (fig 3) and in immunocytochemistry on mouse samples (fig 2). Sci Rep (2016) ncbi |
mouse monoclonal (B-3) |
| In order to research the modulation of beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1 by SEPT8, Santa Cruz Biotechnology Rab7a antibody (Santa Cruz, sc-376362) was used in immunocytochemistry on human samples at 1:50 (fig 6). J Cell Sci (2016) ncbi |
mouse monoclonal (D-4) |
| Santa Cruz Biotechnology Rab7a antibody (Santa Cruz, sc-271608) was used in western blot on human samples at 1:1000 (fig 6). Cell Death Dis (2014) ncbi |
GeneTex
mouse monoclonal (Rab7-117) |
| In order to research the role of C9orf72 in macrophage and microglial function, GeneTex Rab7a antibody (GeneTex, GTX 16196) was used in immunocytochemistry on mouse samples (fig s7a). Science (2016) ncbi |
Cell Signaling Technology
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (CST, 9367) was used in western blot on mouse samples at 1:1000 (fig 5c). Science (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on human samples (fig 2d). Biol Open (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on mouse samples (fig 9e). J Exp Med (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367S) was used in immunocytochemistry on human samples at 1:250 (fig s2). J Cell Sci (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on mouse samples (fig 3a). EMBO J (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367S) was used in western blot on human samples (fig 2e). Cell (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367s) was used in immunocytochemistry on human samples at 1:100 (fig 5a) and in western blot on human samples (fig 6f). Nat Commun (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on mouse samples at 1:200 (fig 6c) and in immunocytochemistry on Drosophila melanogaster samples at 1:5 (fig 2h). elife (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on mouse samples at 1:100 (fig 1d). J Cell Biol (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on mouse samples at 1:100 (fig 6e). J Cell Biol (2019) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in proximity ligation assay on human samples at 1:100 (fig 5b, 5f). Cell Rep (2018) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367S) was used in immunocytochemistry on mouse samples (fig s3g). Cell (2018) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, 9367) was used in western blot on mouse samples (fig 5a). EMBO J (2018) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on mouse samples (fig 7a). J Biol Chem (2018) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on mouse samples (fig 6b). Proc Natl Acad Sci U S A (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on mouse samples (fig s5b). PLoS Genet (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (cell signalling, D95F2) was used in immunocytochemistry on human samples (fig s5). PLoS Pathog (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to investigate Rab7 and Arl8b crosstalk, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunoprecipitation on human samples (fig 5g), in immunocytochemistry on human samples (fig 5k) and in western blot on human samples (fig 5g). J Cell Biol (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on human samples (fig s5e). Nature (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to elucidate a novel pathway for mitochondrial elimination, in which these organelles undergo Parkin-dependent sequestration into Rab5-positive early endosomes via the ESCRT machinery, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on mouse samples at 1:1000 (fig 7c). Nat Commun (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to determine the role of SNAPIN in macrophages, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on human samples (fig 4a) and in western blot on human samples (fig 1c). Autophagy (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to observe that a single amino acid change within Rabep2 accounting for the difference in collateral extent and infarct volume between B6 and BC mice maps to Dce1, Cell Signaling Technology Rab7a antibody (cell signalling, 9367S) was used in western blot on mouse samples at 1:1000 (fig 6a). Stroke (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on mouse samples at 1:300 (fig 3) and in western blot on mouse samples at 1:5000 (fig 3). J Cell Sci (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (cell signalling, 9367) was used in immunocytochemistry on human samples (fig 7a) and in western blot on human samples (fig 7e). PLoS Pathog (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on rat samples (fig 5f). Microbiologyopen (2017) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to elucidate the mechanism by which hypotonic stress reduces claudin-1 and -2 expression in renal tubular epithelial and canine kidney cells, Cell Signaling Technology Rab7a antibody (Cell signaling, 9367) was used in western blot on dogs samples (fig 11a). J Biol Chem (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to report the mechanism by which thrombospondin-4 regulates skeletal muscle integrity, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on mouse samples at 1:100 (fig 1s3). elife (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to show that LAMP-2 is essential for STX17 expression and for fusion of autophagasomes with lysosomes, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on mouse samples (fig s8e). Biol Open (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to study a phosphoinositide-based mechanism that Arf6 uses to control retromer traffic and intracellular cholesterol distribution, Cell Signaling Technology Rab7a antibody (Cell signaling, 9367) was used in immunocytochemistry on mouse samples at 1:100 (fig 1). Nat Commun (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on human samples at 1:100 (fig s1c). Nat Commun (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to analyze control of MT1-MMP endocytic and E-cadherin polarized golgi trafficking to promote invasive breast cancer programs by RAB2A, Cell Signaling Technology Rab7a antibody (Cell signaling, 9367) was used in immunocytochemistry on human samples (fig 4). EMBO Rep (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on human samples (fig 2c). EMBO Rep (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, 9367) was used in immunocytochemistry on mouse samples (fig 2). Mol Metab (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, D95F2) was used in immunocytochemistry on human samples (fig 8a) and in immunocytochemistry on mouse samples (fig 2). Sci Rep (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell signaling, 9367) was used in western blot on human samples at 1:1000 (fig 2). elife (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to use Kcne3 knockout mice to investigate atrial electrophysiology and the development of aldosterone-dependent atrial fibrillation, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on mouse samples at 1:500 (fig 5a). FASEB J (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (CST, 9367) was used in immunocytochemistry on mouse samples (fig s5). Acta Neuropathol (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to study the conversion of phosphatidylinositol 3-phosphate to phosphatidylinositol 4-phosphate at endosomes en route to the plasma membrane, Cell Signaling Technology Rab7a antibody (Cell Signalling, D95F2) was used in immunocytochemistry on human samples at 1:50. Nature (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in western blot on mouse samples at 1:1000 (fig 6d). Oncotarget (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to investigate a mechanism of late endosomal maturation, Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, D95F2) was used in western blot on mouse samples (fig 2). Mol Biol Cell (2016) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (BD, 9367) was used in immunocytochemistry on human samples (fig 2). J Cell Biol (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to investigate the role of p18, Rab4, Rab7, and Rab9 in vessel formation within the pulmonary vasculature, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367S) was used in western blot on rat samples at 1:1000. Am J Physiol Lung Cell Mol Physiol (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to determine the role of PICALM in Abeta transcytosis across the blood brain barrier, Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry on human samples at 1:100 (fig 7) and in western blot on human samples at 1:2000 (fig 7). Nat Neurosci (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to study regulation of selective autophagic clearance of protein aggregates due to proteotoxic stress inducing phosphorylation of p62/SQSTM1 by ULK1, Cell Signaling Technology Rab7a antibody (Cell signaling, 9367) was used in immunocytochemistry on mouse samples (fig 7). PLoS Genet (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to explore a macrophage TLR9-BTK-calcineurin-NFAT signaling pathway involved in impair fungal immunity, Cell Signaling Technology Rab7a antibody (Cell signaling, 9367) was used in immunocytochemistry on mouse samples at 1:50 (fig s7a). EMBO Mol Med (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to study the effect of bisecting N-acetylglucosamine on beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) activity, Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, 9367) was used in western blot on mouse samples (fig 5b). EMBO Mol Med (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on human samples at 1:100. J Clin Invest (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to assess adeno-associated virus transduction and its requirement for syntaxin 5-dependent retrograde transport to the trans-Golgi network, Cell Signaling Technology Rab7a antibody (Cell Signaling Technologies, D95F2) was used in western blot on human samples (fig 4). J Virol (2015) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, D95F2) was used in immunocytochemistry on human samples . J Cell Sci (2014) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling Technology, D95F2) was used in immunocytochemistry on mouse samples . PLoS ONE (2014) ncbi |
domestic rabbit monoclonal (D95F2) |
| In order to study the intracellular role of sorcin, Cell Signaling Technology Rab7a antibody (Cell Signaling, D95F2) was used in immunocytochemistry on mouse samples . PLoS ONE (2014) ncbi |
domestic rabbit monoclonal (D95F2) |
| Cell Signaling Technology Rab7a antibody (Cell Signaling, 9367) was used in immunocytochemistry knockout validation on mouse samples (fig 1), in western blot knockout validation on mouse samples (fig 1) and in flow cytometry on mouse samples (fig 1). Autophagy (2013) ncbi |
Articles Reviewed
- Kober A, Manavalan A, Tam Amersdorfer C, Holmér A, Saeed A, Fanaee Danesh E, et al. Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:573-588 pubmed publisher
- Lucitti J, Sealock R, Buckley B, Zhang H, Xiao L, Dudley A, et al. Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. Stroke. 2016;47:3022-3031 pubmed
- Jaber N, Mohd Naim N, Wang Z, Deleon J, Kim S, Zhong H, et al. Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus. J Cell Sci. 2016;129:4424-4435 pubmed
- Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells. J Biol Chem. 2016;291:24787-24799 pubmed
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