This is a Validated Antibody Database (VAD) review about rat Ptpn6, based on 15 published articles (read how Labome selects the articles), using Ptpn6 antibody in all methods. It is aimed to help Labome visitors find the most suited Ptpn6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ptpn6 synonym: Ptph6; Shp-1

Santa Cruz Biotechnology
mouse monoclonal (D-11)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology Ptpn6 antibody (Santa Cruz biotechnology, sc-7289) was used in western blot on human samples (fig 5a). Cell Rep (2019) ncbi
mouse monoclonal (D-11)
  • western blot; human; loading ...; fig 4b
Santa Cruz Biotechnology Ptpn6 antibody (SantaCruz, sc-7289) was used in western blot on human samples (fig 4b). Mol Cell Biol (2016) ncbi
mouse monoclonal (D-11)
  • immunoprecipitation; human; fig s2
In order to determine the contribution of low molecular weight protein tyrosine phosphatase to colorectal cancer, Santa Cruz Biotechnology Ptpn6 antibody (santa Cruz, sc-7289) was used in immunoprecipitation on human samples (fig s2). Oncotarget (2015) ncbi
mouse monoclonal (D-11)
  • immunoprecipitation; human
  • western blot; human; fig 6
Santa Cruz Biotechnology Ptpn6 antibody (Santa Cruz Biotechnology, SC-7289) was used in immunoprecipitation on human samples and in western blot on human samples (fig 6). PLoS ONE (2014) ncbi
Abcam
domestic rabbit monoclonal (Y476)
  • western blot; mouse; loading ...; fig 2b
Abcam Ptpn6 antibody (Abcam, Y476) was used in western blot on mouse samples (fig 2b). Front Immunol (2020) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:50; fig s5d
Abcam Ptpn6 antibody (Abcam, ab131500) was used in immunohistochemistry - frozen section on mouse samples at 1:50 (fig s5d). Nature (2016) ncbi
domestic rabbit monoclonal (Y476)
  • immunoprecipitation; rat
Abcam Ptpn6 antibody (Abcam, ab32559) was used in immunoprecipitation on rat samples . J Mol Med (Berl) (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; 1:10,000; loading ...; fig s1
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, C14H6) was used in western blot on mouse samples at 1:10,000 (fig s1). Nature (2019) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; loading ...; fig s4g
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 3759) was used in western blot on mouse samples (fig s4g). Cell (2018) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; human; 1:1000; loading ...
Cell Signaling Technology Ptpn6 antibody (cell Signaling, 3759) was used in western blot on human samples at 1:1000. Nature (2018) ncbi
domestic rabbit monoclonal (C14H6)
  • western blot; mouse; 1:1000; fig 1
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, 3759) was used in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C14H6)
  • immunohistochemistry - frozen section; rat; 1:1500
Cell Signaling Technology Ptpn6 antibody (Cell Signaling, C14H6) was used in immunohistochemistry - frozen section on rat samples at 1:1500. Nature (2015) ncbi
BD Biosciences
mouse monoclonal (52/PTP1C/SHP1)
  • western blot; human; loading ...; fig 5c
BD Biosciences Ptpn6 antibody (BD, 610125) was used in western blot on human samples (fig 5c). J Biol Chem (2017) ncbi
mouse monoclonal (52/PTP1C/SHP1)
  • western blot; human; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 8b
BD Biosciences Ptpn6 antibody (BD Biosciences, 610126) was used in western blot on human samples (fig 5b) and in western blot on mouse samples (fig 8b). Redox Biol (2017) ncbi
mouse monoclonal (52/PTP1C/SHP1)
  • western blot; human; fig 3
BD Biosciences Ptpn6 antibody (BD Biosciences, 610126) was used in western blot on human samples (fig 3). Am J Physiol Renal Physiol (2013) ncbi
Articles Reviewed
  1. Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  2. Celis Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Gregoire C, et al. Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy. Cell Rep. 2019;27:3315-3330.e7 pubmed publisher
  3. Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
  4. Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  5. Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
  6. Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  7. Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed publisher
  8. Sauer M, Herbst J, Diekmann U, Rudd C, Kardinal C. SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells. Mol Cell Biol. 2016;36:3113-3127 pubmed
  9. Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536:86-90 pubmed
  10. Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
  11. Hoekstra E, Kodach L, Das A, Ruela de Sousa R, Ferreira C, Hardwick J, et al. Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer. Oncotarget. 2015;6:8300-12 pubmed
  12. Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
  13. Buschmann I, Hackbusch D, Gatzke N, Dülsner A, Trappiel M, Dagnell M, et al. Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats. J Mol Med (Berl). 2014;92:983-94 pubmed publisher
  14. Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, et al. Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. PLoS ONE. 2014;9:e84746 pubmed publisher
  15. Zhou X, Wang H, Burg M, Ferraris J. High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol. 2013;305:F362-9 pubmed publisher