This is a Validated Antibody Database (VAD) review about rat Psen1, based on 24 published articles (read how Labome selects the articles), using Psen1 antibody in all methods. It is aimed to help Labome visitors find the most suited Psen1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Abcam
domestic rabbit monoclonal (EP2000Y)
  • western blot; mouse; 1:2000; loading ...; fig 1b
Abcam Psen1 antibody (Abcam, ab76083) was used in western blot on mouse samples at 1:2000 (fig 1b). elife (2020) ncbi
mouse monoclonal (APS 11)
  • immunocytochemistry; mouse; 1:200; loading ...; fig s1c
Abcam Psen1 antibody (Abcam, ab15456) was used in immunocytochemistry on mouse samples at 1:200 (fig s1c). elife (2019) ncbi
domestic rabbit monoclonal (EP2000Y)
  • western blot; mouse; loading ...; fig 5c
Abcam Psen1 antibody (Abcam, ab76083) was used in western blot on mouse samples (fig 5c). Neurotherapeutics (2018) ncbi
domestic rabbit monoclonal (EP2000Y)
  • immunocytochemistry; rat; loading ...; fig 3a
Abcam Psen1 antibody (Abcam, ab76083) was used in immunocytochemistry on rat samples (fig 3a). Mol Neurodegener (2017) ncbi
mouse monoclonal (APS 11)
  • western blot; rat; loading ...; fig 2d
Abcam Psen1 antibody (Abcam, ab15456) was used in western blot on rat samples (fig 2d). Mol Neurodegener (2017) ncbi
domestic rabbit monoclonal (EP2000Y)
  • western blot; mouse; 1:1000; loading ...; fig 2d
In order to report that the receptor tyrosine kinase AXL is efficiently and sequentially cleaved by alpha- and beta-secretases in various types of cancer cell lines, Abcam Psen1 antibody (Abcam, ab76083) was used in western blot on mouse samples at 1:1000 (fig 2d). FASEB J (2017) ncbi
Invitrogen
mouse monoclonal (APS 18)
  • western blot; mouse; 1:250; tbl 1
  • western blot; human; 1:250; tbl 1
In order to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice, Invitrogen Psen1 antibody (Pierce, APS 18) was used in western blot on mouse samples at 1:250 (tbl 1) and in western blot on human samples at 1:250 (tbl 1). Front Cell Neurosci (2015) ncbi
mouse monoclonal (APS 18)
  • western blot; mouse
In order to study the self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated after stroke, Invitrogen Psen1 antibody (Thermo Scientific, MA1-752) was used in western blot on mouse samples . J Neurosci (2012) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D39D1)
  • western blot; mouse; loading ...; fig 4c
  • western blot; human; fig 1c
Cell Signaling Technology Psen1 antibody (Cell Signaling, D39D1) was used in western blot on mouse samples (fig 4c) and in western blot on human samples (fig 1c). Int J Mol Sci (2022) ncbi
domestic rabbit monoclonal (D39D1)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2e
Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, 5643) was used in immunohistochemistry on mouse samples at 1:100 (fig 2e). J Clin Invest (2022) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; human; 1:1000; fig s7f
Cell Signaling Technology Psen1 antibody (Cell Signaling, 5643) was used in western blot on human samples at 1:1000 (fig s7f). Signal Transduct Target Ther (2021) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; mouse; 1:1000; loading ...; fig 3a
Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, 5643) was used in western blot on mouse samples at 1:1000 (fig 3a). Alzheimers Res Ther (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3e
Cell Signaling Technology Psen1 antibody (Cell Signaling, 3622S) was used in western blot on human samples (fig 3e). Mol Neurodegener (2020) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; human; loading ...; fig 5g
Cell Signaling Technology Psen1 antibody (Cell Signaling, 5643) was used in western blot on human samples (fig 5g). Sci Adv (2020) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; mouse; loading ...; fig s1a
Cell Signaling Technology Psen1 antibody (Cell Signaling, 5643) was used in western blot on mouse samples (fig s1a). Cell (2019) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; mouse; 1:1000; loading ...; fig s3e
Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, 5643) was used in western blot on mouse samples at 1:1000 (fig s3e). J Clin Invest (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 3d
In order to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype, Cell Signaling Technology Psen1 antibody (Cell Signaling, 3622S) was used in western blot on mouse samples (fig 3d). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; rat; loading ...; fig 2d
Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, mAb5643) was used in western blot on rat samples (fig 2d). Mol Neurodegener (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 4
In order to identify and characterize a DYRK1A inhibitor, Cell Signaling Technology Psen1 antibody (Cell Signaling, 3622) was used in western blot on human samples at 1:1000 (fig 4). Dis Model Mech (2016) ncbi
domestic rabbit monoclonal (D39D1)
  • immunoprecipitation; mouse; fig 4d
  • western blot; mouse; fig 3b
  • western blot; hamsters; fig 6b
In order to study the activity-driven interaction between presenilin 1 and synaptotagmin 1 and links to calcium, amyloid beta, and synapse, Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, D3901) was used in immunoprecipitation on mouse samples (fig 4d), in western blot on mouse samples (fig 3b) and in western blot on hamsters samples (fig 6b). BMC Biol (2016) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; human; fig 5
In order to characterize promotion of non-productive angiogenesis by inhibition of endothelial Cdk5 that reduces tumor growth, Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, 5643) was used in western blot on human samples (fig 5). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; human; fig s2
Cell Signaling Technology Psen1 antibody (Cell Signaling Tech, 5643) was used in western blot on human samples (fig s2). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D39D1)
  • immunoprecipitation; human
  • western blot; human
In order to study cadherin-11 extracellular domain fragments in rheumatoid arthritis, Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, D39D1) was used in immunoprecipitation on human samples and in western blot on human samples . Arthritis Res Ther (2015) ncbi
domestic rabbit monoclonal (D39D1)
  • western blot; human
In order to investigate presenilin assembly and catalytic activity, Cell Signaling Technology Psen1 antibody (Cell Signaling, D39D1) was used in western blot on human samples . J Biol Chem (2015) ncbi
domestic rabbit monoclonal (D39D1)
  • immunohistochemistry - paraffin section; rat; 1:1000
  • western blot; rat; 1:1000
Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, 5643S) was used in immunohistochemistry - paraffin section on rat samples at 1:1000 and in western blot on rat samples at 1:1000. Mol Neurobiol (2016) ncbi
domestic rabbit monoclonal (D39D1)
  • immunohistochemistry; rat
  • western blot; rat; 1:1000
Cell Signaling Technology Psen1 antibody (Cell Signaling Technology, 5643S) was used in immunohistochemistry on rat samples and in western blot on rat samples at 1:1000. Toxicol Sci (2015) ncbi
Articles Reviewed
  1. Wuli W, Lin S, Chen S, Tannous B, Huang W, Woon P, et al. Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function. Int J Mol Sci. 2022;23: pubmed publisher
  2. Dave J, Chakraborty R, Ntokou A, Saito J, Saddouk F, Feng Z, et al. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. J Clin Invest. 2022;132: pubmed publisher
  3. Luo R, Fan Y, Yang J, Ye M, Zhang D, Guo K, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduct Target Ther. 2021;6:325 pubmed publisher
  4. Escamilla Ayala A, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, et al. Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface. elife. 2020;9: pubmed publisher
  5. Gee M, Son S, Jeon S, Do J, Kim N, Ju Y, et al. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. 2020;12:45 pubmed publisher
  6. Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
  7. Liu H, Mei F, Yang W, Wang H, Wong E, Cai J, et al. Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling. Sci Adv. 2020;6:eaay3566 pubmed publisher
  8. Javier Torrent M, Marco S, Rocandio D, Pons Vizcarra M, Janes P, Lackmann M, et al. Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA. elife. 2019;8: pubmed publisher
  9. Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher
  10. Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
  11. Huang M, Qi W, Fang S, Jiang P, Yang C, Mo Y, et al. Pigment Epithelium-Derived Factor Plays a Role in Alzheimer's Disease by Negatively Regulating Aβ42. Neurotherapeutics. 2018;15:728-741 pubmed publisher
  12. Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher
  13. Zoltowska K, Maesako M, Lushnikova I, Takeda S, Keller L, Skibo G, et al. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Mol Neurodegener. 2017;12:15 pubmed publisher
  14. Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, et al. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. FASEB J. 2017;31:1382-1397 pubmed publisher
  15. Kim H, Lee K, Kim A, Choi M, Choi K, Kang M, et al. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech. 2016;9:839-48 pubmed publisher
  16. Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  17. Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
  18. Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb J, et al. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016;7:6088-104 pubmed publisher
  19. Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed publisher
  20. Noss E, Watts G, Zocco D, Keller T, Whitman M, Blobel C, et al. Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Res Ther. 2015;17:126 pubmed publisher
  21. Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero A, Dewachter I, et al. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem. 2015;290:7169-84 pubmed publisher
  22. Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher
  23. Ashok A, Rai N, Tripathi S, Bandyopadhyay S. Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. Toxicol Sci. 2015;143:64-80 pubmed publisher
  24. Shimada I, LeComte M, Granger J, Quinlan N, Spees J. Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci. 2012;32:7926-40 pubmed publisher