This is a Validated Antibody Database (VAD) review about rat Pink1, based on 32 published articles (read how Labome selects the articles), using Pink1 antibody in all methods. It is aimed to help Labome visitors find the most suited Pink1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Pink1 synonym: serine/threonine-protein kinase PINK1, mitochondrial

Knockout validation
Novus Biologicals
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig s20c
Novus Biologicals Pink1 antibody (Novus, BC-100-494) was used in western blot knockout validation on human samples (fig s20c). Nucleic Acids Res (2017) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot; human; loading ...; fig 1a
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples (fig 1a). Cell Death Differ (2018) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2a
Novus Biologicals Pink1 antibody (Novusbio, BC100-494) was used in western blot on mouse samples at 1:1000 (fig 2a). Endocrinology (2018) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3e
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples at 1:1000 (fig 3e). J Biol Chem (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 4
Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in western blot on human samples at 1:1000 (fig 4). Hum Mol Genet (2017) ncbi
rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 3g
  • immunocytochemistry; human; loading ...; fig 3h
  • western blot; human; loading ...; fig 4a
Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in immunoprecipitation on human samples (fig 3g), in immunocytochemistry on human samples (fig 3h) and in western blot on human samples (fig 4a). Oncotarget (2017) ncbi
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig s20c
Novus Biologicals Pink1 antibody (Novus, BC-100-494) was used in western blot knockout validation on human samples (fig s20c). Nucleic Acids Res (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4a
In order to investigate the contribution of PINK1 and PARKIN to cell death, Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in western blot on human samples (fig 4a). J Biol Chem (2016) ncbi
rabbit polyclonal
  • proximity ligation assay; human; fig 2
  • western blot; human; fig 1
In order to study how Parkin is responsible for polyubiquitination of apurinic/apyrimidinic endonuclease 1, Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in proximity ligation assay on human samples (fig 2) and in western blot on human samples (fig 1). Mol Carcinog (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 3a
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples (fig 3a). J Neurochem (2016) ncbi
rabbit polyclonal
  • western blot; human
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples . Cell Signal (2015) ncbi
rabbit polyclonal
  • immunoprecipitation; human; fig 3
  • immunocytochemistry; human; fig 5
  • western blot; human; fig 1
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in immunoprecipitation on human samples (fig 3), in immunocytochemistry on human samples (fig 5) and in western blot on human samples (fig 1). J Biol Chem (2015) ncbi
rabbit polyclonal
  • immunoprecipitation; human; 1:1000; fig 1
  • immunocytochemistry; human; 1:1000; fig 5
  • western blot; human
In order to investigate how PINK1 recruits Parkin, Novus Biologicals Pink1 antibody (Santa Cruz Biotechnology, PN BC100-494) was used in immunoprecipitation on human samples at 1:1000 (fig 1), in immunocytochemistry on human samples at 1:1000 (fig 5) and in western blot on human samples . J Cell Biol (2015) ncbi
rabbit polyclonal
  • western blot; human
  • western blot; mouse; loading ...; fig 5a, 5b, 5c
Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in western blot on human samples and in western blot on mouse samples (fig 5a, 5b, 5c). EMBO Mol Med (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig s2a
In order to study the role of Jnk2 in mitophagy., Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on mouse samples (fig s2a). Nat Immunol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 2f
Novus Biologicals Pink1 antibody (Novus Biological, BC100-494) was used in western blot on mouse samples (fig 2f). Autophagy (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:50
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in immunohistochemistry - paraffin section on mouse samples at 1:50. PLoS Genet (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 1
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples at 1:1000 (fig 1). Cell Res (2015) ncbi
rabbit polyclonal
  • western blot; human
  • western blot; mouse; 1:1,000
In order to examine the involvement of lysine 63-linked polyubiquitin during Parkin-mediated mitophagy, Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples and in western blot on mouse samples at 1:1,000. J Biol Chem (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; loading ...; fig s2c
  • immunoprecipitation; human
  • western blot; human; fig 1a
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in immunocytochemistry on mouse samples (fig s2c), in immunoprecipitation on human samples and in western blot on human samples (fig 1a). Hum Mol Genet (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:500
In order to identify E2s that regulate the activation, translocation, and enzymatic functions of Parkin during mitochondrial quality control, Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in western blot on human samples at 1:500. J Cell Sci (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:300
In order to report and characterize the interaction between BECN1 and PARK2, Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in western blot on human samples at 1:300. Autophagy (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; human
  • western blot; human
Novus Biologicals Pink1 antibody (Novus Biologicals, BC100-494) was used in immunocytochemistry on human samples and in western blot on human samples . Neurobiol Dis (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Novus Biologicals Pink1 antibody (Novus, BC100-494) was used in western blot on mouse samples . J Biol Chem (2013) ncbi
Abcam
rabbit polyclonal
  • flow cytometry; human; 1:100-1:200; loading ...; fig s5f
  • flow cytometry; mouse; 1:100-1:200; loading ...; fig s5e
Abcam Pink1 antibody (Abcam, ab23707) was used in flow cytometry on human samples at 1:100-1:200 (fig s5f) and in flow cytometry on mouse samples at 1:100-1:200 (fig s5e). Cell Stem Cell (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1e
Abcam Pink1 antibody (Abcam, ab23707) was used in western blot on human samples (fig 1e). Cell Syst (2017) ncbi
rabbit polyclonal
  • immunohistochemistry; human; fig 2
  • western blot; human; fig 2
Abcam Pink1 antibody (Abcam, 23707) was used in immunohistochemistry on human samples (fig 2) and in western blot on human samples (fig 2). J Immunol (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:500; fig 5
  • western blot; human; 1:1000; fig 5
Abcam Pink1 antibody (Abcam, ab23707) was used in immunocytochemistry on human samples at 1:500 (fig 5) and in western blot on human samples at 1:1000 (fig 5). Sci Rep (2016) ncbi
rabbit polyclonal
  • other; mouse; 1:1000; fig s4
Abcam Pink1 antibody (Abcam, ab23707) was used in other on mouse samples at 1:1000 (fig s4). Nat Commun (2015) ncbi
rabbit polyclonal
  • immunohistochemistry; pig
Abcam Pink1 antibody (Abcam, ab23707) was used in immunohistochemistry on pig samples . Cell Mol Life Sci (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 1
Abcam Pink1 antibody (Abcam, ab23707) was used in western blot on mouse samples (fig 1). Biochim Biophys Acta (2015) ncbi
rabbit polyclonal
  • western blot; human
Abcam Pink1 antibody (abcam, ab23707) was used in western blot on human samples . PLoS ONE (2014) ncbi
Proteintech Group
rabbit polyclonal
  • proximity ligation assay; human; fig 2
  • western blot; human; fig 1
In order to study how Parkin is responsible for polyubiquitination of apurinic/apyrimidinic endonuclease 1, Proteintech Group Pink1 antibody (Protein Tech, 23274-1-AP) was used in proximity ligation assay on human samples (fig 2) and in western blot on human samples (fig 1). Mol Carcinog (2017) ncbi
EMD Millipore
mouse monoclonal (N4/15)
  • immunohistochemistry - paraffin section; mouse; 1:200
  • western blot; mouse
EMD Millipore Pink1 antibody (Millipore, N4/15) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 and in western blot on mouse samples . J Immunol (2014) ncbi
Articles Reviewed
  1. Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  2. Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed publisher
  3. Malty R, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, et al. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017;5:564-577.e12 pubmed publisher
  4. Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed publisher
  5. Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed publisher
  6. Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
  7. Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher
  8. Wettengel J, Reautschnig P, Geisler S, Kahle P, Stafforst T. Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res. 2017;45:2797-2808 pubmed publisher
  9. Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed publisher
  10. Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
  11. Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed publisher
  12. Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep. 2016;6:24700 pubmed publisher
  13. Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed publisher
  14. Wu S, Kao C, Wang L, Creighton C, Yang J, Donti T, et al. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015;6:8245 pubmed publisher
  15. Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed publisher
  16. Lim G, Chua D, Basil A, Chan H, Chai C, Arumugam T, et al. Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy. J Biol Chem. 2015;290:16882-93 pubmed publisher
  17. Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed publisher
  18. Seillier M, Pouyet L, N Guessan P, Nollet M, Capo F, Guillaumond F, et al. Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med. 2015;7:802-18 pubmed publisher
  19. Zhang Q, Kuang H, Chen C, Yan J, Do Umehara H, Liu X, et al. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol. 2015;16:458-66 pubmed publisher
  20. Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, et al. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy. 2015;11:166-82 pubmed publisher
  21. Bifsha P, Yang J, Fisher R, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10:e1004863 pubmed publisher
  22. Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, et al. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015;25:394-7 pubmed publisher
  23. Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy. J Biol Chem. 2014;289:33131-6 pubmed publisher
  24. Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed publisher
  25. Zhou X, Xin J, Fan N, Zou Q, Huang J, Ouyang Z, et al. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cell Mol Life Sci. 2015;72:1175-84 pubmed publisher
  26. Roe N, Xu X, Kandadi M, Hu N, Pang J, Weiser Evans M, et al. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015;1852:290-8 pubmed publisher
  27. Fiesel F, Moussaud Lamodière E, Ando M, Springer W. A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently. J Cell Sci. 2014;127:3488-504 pubmed publisher
  28. Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed publisher
  29. Zhang Y, Sauler M, Shinn A, Gong H, Haslip M, Shan P, et al. Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury. J Immunol. 2014;192:5296-304 pubmed publisher
  30. Zou J, Yue F, Li W, Song K, Jiang X, Yi J, et al. Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin. PLoS ONE. 2014;9:e94903 pubmed publisher
  31. Gómez Sánchez R, Gegg M, Bravo San Pedro J, Niso Santano M, Alvarez Erviti L, Pizarro Estrella E, et al. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. Neurobiol Dis. 2014;62:426-40 pubmed publisher
  32. Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, et al. Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J Biol Chem. 2013;288:22019-32 pubmed publisher