This is a Validated Antibody Database (VAD) review about rat Pc, based on 10 published articles (read how Labome selects the articles), using Pc antibody in all methods. It is aimed to help Labome visitors find the most suited Pc antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Pc synonym: Pcx; pyruvate carboxylase, mitochondrial; PCB; pyruvic carboxylase

Abcam
rabbit monoclonal (EPR7366)
  • western blot; human; loading ...; fig 5a
Abcam Pc antibody (Abcam, ab126707) was used in western blot on human samples (fig 5a). Oncotarget (2017) ncbi
rabbit monoclonal (EPR7365)
  • western blot; mouse; loading ...; fig 6b
In order to identify posttranscriptional mechanisms that regulate mitochondrial protein expression, Abcam Pc antibody (Abcam, ab128952) was used in western blot on mouse samples (fig 6b). J Cell Biol (2017) ncbi
rabbit monoclonal (EPR7365)
  • western blot; mouse; 1:1000; fig 7
Abcam Pc antibody (Abcam, Ab128952) was used in western blot on mouse samples at 1:1000 (fig 7). Nat Commun (2016) ncbi
rabbit monoclonal (EPR7366)
  • western blot; human; 1:10,000; fig 4
Abcam Pc antibody (Abcam, ab126707) was used in western blot on human samples at 1:10,000 (fig 4). Nat Cell Biol (2015) ncbi
rabbit monoclonal (EPR7365)
  • western blot; mouse
In order to study the metabolic responses during chronic pressure overloads in mouse hearts expressing ssTnI, Abcam Pc antibody (Abcam, ab128952) was used in western blot on mouse samples . Circ Heart Fail (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-2)
  • western blot; rat; fig s1t
Santa Cruz Biotechnology Pc antibody (SantaCruz, sc-271493) was used in western blot on rat samples (fig s1t). Cell (2018) ncbi
mouse monoclonal (H-2)
  • western blot; mouse; loading ...; fig 5
Santa Cruz Biotechnology Pc antibody (SantaCruz, sc-271493) was used in western blot on mouse samples (fig 5). J Physiol Sci (2018) ncbi
mouse monoclonal (H-2)
  • western blot; human; loading ...; fig 4a
Santa Cruz Biotechnology Pc antibody (Santa Cruz, sc-271493) was used in western blot on human samples (fig 4a). Oncotarget (2016) ncbi
mouse monoclonal (H-2)
  • western blot; rat; fig e3
Santa Cruz Biotechnology Pc antibody (Santa Cruz Biotechnology, sc-271493) was used in western blot on rat samples (fig e3). Nature (2014) ncbi
Proteintech Group
rabbit polyclonal
  • western blot; human
Proteintech Group Pc antibody (Proteintech Group, 16588-1-AP) was used in western blot on human samples . PLoS ONE (2014) ncbi
Articles Reviewed
  1. Perry R, Wang Y, Cline G, Rabin Court A, Song J, Dufour S, et al. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell. 2018;172:234-248.e17 pubmed publisher
  2. Muñoz V, Gaspar R, Crisol B, Formigari G, Sant Ana M, Botezelli J, et al. Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice. J Physiol Sci. 2018;68:493-501 pubmed publisher
  3. Kitazawa S, Ebara S, Ando A, Baba Y, Satomi Y, Soga T, et al. Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors. Oncotarget. 2017;8:28922-28938 pubmed publisher
  4. Schatton D, Pla Martín D, Marx M, Hansen H, Mourier A, Nemazanyy I, et al. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017;216:675-693 pubmed publisher
  5. Yin C, He D, Chen S, Tan X, Sang N. Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate. Oncotarget. 2016;7:47494-47510 pubmed publisher
  6. Li X, Cheng K, Liu Z, Yang J, Wang B, Jiang X, et al. The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic ?-cells. Nat Commun. 2016;7:11740 pubmed publisher
  7. Cardaci S, Zheng L, Mackay G, van den Broek N, MacKenzie E, Nixon C, et al. Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nat Cell Biol. 2015;17:1317-26 pubmed publisher
  8. Ulanet D, Couto K, Jha A, Choe S, Wang A, Woo H, et al. Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition. PLoS ONE. 2014;9:e115144 pubmed publisher
  9. Carley A, Taglieri D, Bi J, Solaro R, Lewandowski E. Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I. Circ Heart Fail. 2015;8:119-27 pubmed publisher
  10. Madiraju A, Erion D, Rahimi Y, Zhang X, Braddock D, Albright R, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014;510:542-6 pubmed publisher