This is a Validated Antibody Database (VAD) review about rat Numb, based on 17 published articles (read how Labome selects the articles), using Numb antibody in all methods. It is aimed to help Labome visitors find the most suited Numb antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Numb synonym: protein numb homolog; numb gene homolog; numb homolog

Abcam
rabbit polyclonal
  • immunocytochemistry; human; fig 3d
Abcam Numb antibody (Abcam, ab14140) was used in immunocytochemistry on human samples (fig 3d). Cell (2018) ncbi
rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 1a
  • western blot; human; loading ...; fig 1a
In order to research the role of cargo protein MAP17 in cancer stem cells, Abcam Numb antibody (Abcam, ab14140) was used in immunoprecipitation on human samples (fig 1a) and in western blot on human samples (fig 1a). Clin Cancer Res (2017) ncbi
goat polyclonal
  • western blot; mouse; loading ...; fig s3a
In order to study NaV1.7 trafficking, Abcam Numb antibody (Abcam, ab4147) was used in western blot on mouse samples (fig s3a). Proc Natl Acad Sci U S A (2016) ncbi
goat polyclonal
  • immunohistochemistry - frozen section; mouse; 1:400; fig 1s2
In order to determine the contribution of TBC1D3 to cortical folding, Abcam Numb antibody (Abcam, ab4147) was used in immunohistochemistry - frozen section on mouse samples at 1:400 (fig 1s2). elife (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; fig 1
Abcam Numb antibody (Abcam, ab14140) was used in immunocytochemistry on mouse samples (fig 1). Nature (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:250; fig 5
Abcam Numb antibody (Abcam, ab14140) was used in western blot on human samples at 1:250 (fig 5). Nat Commun (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; fig 5e
  • western blot; mouse; fig 5d
Abcam Numb antibody (Abcam, ab14140) was used in immunocytochemistry on mouse samples (fig 5e) and in western blot on mouse samples (fig 5d). Nat Commun (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; dog; fig s2a
In order to assess the contribution of aPKC to epithelial cell transformation, Abcam Numb antibody (Abcam, ab14140) was used in immunocytochemistry on dog samples (fig s2a). Mol Biol Cell (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig st13
  • immunoprecipitation; human; loading ...; fig st13
  • immunocytochemistry; human; 1:200; loading ...; fig st13
  • western blot; human; 1:1000; loading ...; fig st13
Abcam Numb antibody (abcam, ab14140) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig st13), in immunoprecipitation on human samples (fig st13), in immunocytochemistry on human samples at 1:200 (fig st13) and in western blot on human samples at 1:1000 (fig st13). Nat Cell Biol (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (48)
  • western blot; human; 1:1000; loading ...; fig 4a
Santa Cruz Biotechnology Numb antibody (Santa Cruz, sc-136554) was used in western blot on human samples at 1:1000 (fig 4a). Apoptosis (2017) ncbi
mouse monoclonal (48)
  • immunocytochemistry; dog; 1:200; loading ...; fig 6b
In order to find and characterize the interaction between Eps15 and pS227-FIP2, Santa Cruz Biotechnology Numb antibody (Santa Cruz Biotechnology, SC-136554) was used in immunocytochemistry on dog samples at 1:200 (fig 6b). Mol Biol Cell (2017) ncbi
Cell Signaling Technology
rabbit monoclonal (C29G11)
  • western blot; human; loading ...; fig 3e
Cell Signaling Technology Numb antibody (Cell Signaling Technology, 2756) was used in western blot on human samples (fig 3e). Cancer Res (2017) ncbi
rabbit monoclonal (C29G11)
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s1b
  • western blot; mouse; 1:250; loading ...; fig 3c
Cell Signaling Technology Numb antibody (Cell Signaling Technology, C29G11) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig s1b) and in western blot on mouse samples at 1:250 (fig 3c). J Clin Invest (2017) ncbi
rabbit monoclonal (C29G11)
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...
Cell Signaling Technology Numb antibody (Cell Signaling, C29G11) was used in immunohistochemistry - frozen section on mouse samples at 1:400. Proc Natl Acad Sci U S A (2016) ncbi
rabbit monoclonal (C29G11)
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology Numb antibody (Cell signaling, 2756) was used in western blot on mouse samples (fig 1f). Cell Death Dis (2016) ncbi
rabbit monoclonal (C29G11)
  • western blot; human
Cell Signaling Technology Numb antibody (Cell Signaling Technology, C29G11) was used in western blot on human samples . Cancer Res (2013) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; fig 3d
Sigma-Aldrich Numb antibody (Sigma Aldrich, N6539) was used in western blot on human samples (fig 3d). Science (2017) ncbi
Articles Reviewed
  1. Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
  2. Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed publisher
  3. Chavali P, Stojic L, Meredith L, Joseph N, Nahorski M, Sanford T, et al. Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication. Science. 2017;357:83-88 pubmed publisher
  4. Lian W, Zhang L, Yang L, Chen W. AP-2α reverses vincristine-induced multidrug resistance of SGC7901 gastric cancer cells by inhibiting the Notch pathway. Apoptosis. 2017;22:933-941 pubmed publisher
  5. Lapierre L, Manning E, Mitchell K, Caldwell C, Goldenring J. Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition. Mol Biol Cell. 2017;28:1088-1100 pubmed publisher
  6. García Heredia J, Lucena Cacace A, Verdugo Sivianes E, Pérez M, Carnero A. The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB. Clin Cancer Res. 2017;23:3871-3883 pubmed publisher
  7. Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed publisher
  8. Dustrude E, Moutal A, Yang X, Wang Y, Khanna M, Khanna R. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. Proc Natl Acad Sci U S A. 2016;113:E8443-E8452 pubmed publisher
  9. Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed
  10. Ju X, Hou Q, Sheng A, Wu K, Zhou Y, Jin Y, et al. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. elife. 2016;5: pubmed publisher
  11. Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed publisher
  12. Verbist K, Guy C, Milasta S, Liedmann S, Kaminski M, Wang R, et al. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 2016;532:389-93 pubmed publisher
  13. Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies F, et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016;7:10533 pubmed publisher
  14. Yu C, Rafiq N, Cao F, Zhou Y, Krishnasamy A, Biswas K, et al. Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force. Nat Commun. 2015;6:8672 pubmed publisher
  15. Archibald A, Al Masri M, Liew Spilger A, McCaffrey L. Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell. 2015;26:3578-95 pubmed publisher
  16. Hwang W, Jiang J, Yang S, Huang T, Lan H, Teng H, et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-80 pubmed publisher
  17. Camps J, Pitt J, Emons G, Hummon A, Case C, Grade M, et al. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. Cancer Res. 2013;73:2003-13 pubmed publisher