This is a Validated Antibody Database (VAD) review about rat Npc1, based on 4 published articles (read how Labome selects the articles), using Npc1 antibody in all methods. It is aimed to help Labome visitors find the most suited Npc1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Npc1 synonym: Cdig2; SLC66A1

Knockout validation
Abcam
domestic rabbit monoclonal (EPR5209)
  • western blot knockout validation; human; 1:2000; loading ...; fig 8c
Abcam Npc1 antibody (Abcam, ab134113) was used in western blot knockout validation on human samples at 1:2000 (fig 8c). elife (2019) ncbi
Abcam
domestic rabbit monoclonal (EPR5209)
  • western blot; human; 1:3000; loading ...
Abcam Npc1 antibody (Abcam, EPR5209) was used in western blot on human samples at 1:3000. Nature (2020) ncbi
domestic rabbit monoclonal (EPR5209)
  • western blot; mouse; loading ...; fig 1c
Abcam Npc1 antibody (Abcam, ab134113) was used in western blot on mouse samples (fig 1c). Dis Model Mech (2020) ncbi
domestic rabbit monoclonal (EPR5209)
  • western blot knockout validation; human; 1:2000; loading ...; fig 8c
Abcam Npc1 antibody (Abcam, ab134113) was used in western blot knockout validation on human samples at 1:2000 (fig 8c). elife (2019) ncbi
domestic rabbit monoclonal (EPR5209)
  • western blot; mouse; loading ...; fig 5a
Abcam Npc1 antibody (Abcam, ab134113) was used in western blot on mouse samples (fig 5a). Sci Rep (2017) ncbi
Articles Reviewed
  1. Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisher
  2. Rodriguez Gil J, Watkins Chow D, Baxter L, Elliot G, Harper U, Wincovitch S, et al. Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1. Dis Model Mech. 2020;13: pubmed publisher
  3. McCauliff L, Langan A, Li R, Ilnytska O, Bose D, Waghalter M, et al. Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid. elife. 2019;8: pubmed publisher
  4. Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher