This is a Validated Antibody Database (VAD) review about rat Notch2, based on 26 published articles (read how Labome selects the articles), using Notch2 antibody in all methods. It is aimed to help Labome visitors find the most suited Notch2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D67C8)
  • immunohistochemistry knockout validation; mouse; 1:2000; loading ...; fig ed7c
  • immunohistochemistry - frozen section; mouse; 1:2000; loading ...; fig 2b
Cell Signaling Technology Notch2 antibody (Cell Signaling, D67C8) was used in immunohistochemistry knockout validation on mouse samples at 1:2000 (fig ed7c) and in immunohistochemistry - frozen section on mouse samples at 1:2000 (fig 2b). Nature (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D76A6)
  • western blot; human; 1:100; loading ...
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology, 5732) was used in western blot on human samples at 1:100. J Clin Invest (2022) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; mouse; 1:100; fig s4-1d
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology, 5732) was used in western blot on mouse samples at 1:100 (fig s4-1d). elife (2020) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1c
Cell Signaling Technology Notch2 antibody (CST, 5732) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 1c). Aging (Albany NY) (2020) ncbi
domestic rabbit monoclonal (D67C8)
  • western blot; human; loading ...; fig s1a, s1b
Cell Signaling Technology Notch2 antibody (Cell Signaling, 4530) was used in western blot on human samples (fig s1a, s1b). Mol Cancer (2019) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; mouse; 1:1000; loading ...; fig f1s3b
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in western blot on mouse samples at 1:1000 (fig f1s3b). elife (2019) ncbi
domestic rabbit monoclonal (D76A6)
  • immunocytochemistry; human; 1:100; fig 2g
  • western blot; human; 1:1000; loading ...; fig 2e
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in immunocytochemistry on human samples at 1:100 (fig 2g) and in western blot on human samples at 1:1000 (fig 2e). Nat Commun (2018) ncbi
domestic rabbit monoclonal (D76A6)
  • immunocytochemistry; human; loading ...; fig 7g
  • western blot; human; loading ...; fig 7c
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in immunocytochemistry on human samples (fig 7g) and in western blot on human samples (fig 7c). Cell Death Dis (2018) ncbi
domestic rabbit monoclonal (D76A6)
  • immunocytochemistry; human; 1:100; loading ...; fig 6f
  • western blot; human; 1:1000; loading ...; fig 3a
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in immunocytochemistry on human samples at 1:100 (fig 6f) and in western blot on human samples at 1:1000 (fig 3a). Nat Commun (2017) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; mouse; 1:200; fig 5b
Cell Signaling Technology Notch2 antibody (CST, D76A6) was used in western blot on mouse samples at 1:200 (fig 5b). Life Sci (2018) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - paraffin section; mouse; 1:200; fig s2g
  • western blot; mouse; fig 2c
In order to study the effect of Notch signalling on small-cell lung cancer progression, Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig s2g) and in western blot on mouse samples (fig 2c). Nature (2017) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; rat; fig 6a
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology, 5732) was used in western blot on rat samples (fig 6a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; human; 1:1000; fig 4a
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology, 5732) was used in western blot on human samples at 1:1000 (fig 4a). Nat Commun (2017) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - frozen section; mouse; 1:600; loading ...
Cell Signaling Technology Notch2 antibody (Cell Signaling, D76A6) was used in immunohistochemistry - frozen section on mouse samples at 1:600. Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; human; fig 6d
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in western blot on human samples (fig 6d). Biochem Pharmacol (2016) ncbi
domestic rabbit monoclonal (D67C8)
  • immunohistochemistry knockout validation; mouse; 1:2000; loading ...; fig ed7c
  • immunohistochemistry - frozen section; mouse; 1:2000; loading ...; fig 2b
Cell Signaling Technology Notch2 antibody (Cell Signaling, D67C8) was used in immunohistochemistry knockout validation on mouse samples at 1:2000 (fig ed7c) and in immunohistochemistry - frozen section on mouse samples at 1:2000 (fig 2b). Nature (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - frozen section; mouse; 1:400; fig 3
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in immunohistochemistry - frozen section on mouse samples at 1:400 (fig 3). Development (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - paraffin section; human; 1:100
In order to develop and characterize patient-derived primary xenografts to a model of muscle invasive bladder cancer, Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732) was used in immunohistochemistry - paraffin section on human samples at 1:100. Oncotarget (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - paraffin section; mouse; fig 2
Cell Signaling Technology Notch2 antibody (Cell Signaling Tech, 5732) was used in immunohistochemistry - paraffin section on mouse samples (fig 2). Oncotarget (2015) ncbi
domestic rabbit monoclonal (D67C8)
  • immunohistochemistry - paraffin section; human
  • western blot; human; 1:1000
In order to investigate the role of Notch signaling in human basal cell differentiation, Cell Signaling Technology Notch2 antibody (Cell Signaling, 4530) was used in immunohistochemistry - paraffin section on human samples and in western blot on human samples at 1:1000. PLoS ONE (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
  • western blot; human; fig s2
Cell Signaling Technology Notch2 antibody (Cell Signaling, D76A6) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 1) and in western blot on human samples (fig s2). Placenta (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • other; human; loading ...; fig 5b
  • western blot; human; loading ...; fig 5a
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology Inc., 5732) was used in other on human samples (fig 5b) and in western blot on human samples (fig 5a). Mol Carcinog (2015) ncbi
domestic rabbit monoclonal (D67C8)
  • western blot; human; fig 1
Cell Signaling Technology Notch2 antibody (Cell Signaling, 4530) was used in western blot on human samples (fig 1). Oncotarget (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; human; fig 1b
Cell Signaling Technology Notch2 antibody (Cell Signaling, 5732S) was used in western blot on human samples (fig 1b). Leukemia (2015) ncbi
domestic rabbit monoclonal (D76A6)
  • western blot; human
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology, 5732) was used in western blot on human samples . PLoS ONE (2014) ncbi
domestic rabbit monoclonal (D67C8)
  • western blot; human
Cell Signaling Technology Notch2 antibody (Cell Signaling Technology, 4530P) was used in western blot on human samples . PLoS ONE (2014) ncbi
domestic rabbit monoclonal (D67C8)
  • western blot; human
Cell Signaling Technology Notch2 antibody (Cell Signaling, 4530) was used in western blot on human samples . Cell Cycle (2014) ncbi
Articles Reviewed
  1. Dave J, Chakraborty R, Ntokou A, Saito J, Saddouk F, Feng Z, et al. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. J Clin Invest. 2022;132: pubmed publisher
  2. Pan L, Lemieux M, Thomas T, Rogers J, Lipper C, Lee W, et al. IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation. elife. 2020;9: pubmed publisher
  3. Hu J, Yu J, Gan J, Song N, Shi L, Liu J, et al. Notch1/2/3/4 are prognostic biomarker and correlated with immune infiltrates in gastric cancer. Aging (Albany NY). 2020;12:2595-2609 pubmed publisher
  4. Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019;18:156 pubmed publisher
  5. Nandagopal N, Santat L, Elowitz M. Cis-activation in the Notch signaling pathway. elife. 2019;8: pubmed publisher
  6. Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed publisher
  7. Huang G, Jiang H, Lin Y, Wu Y, Cai W, Shi B, et al. lncAKHE enhances cell growth and migration in hepatocellular carcinoma via activation of NOTCH2 signaling. Cell Death Dis. 2018;9:487 pubmed publisher
  8. Bhardwaj A, Yang Y, Ueberheide B, Smith S. Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation. Nat Commun. 2017;8:2214 pubmed publisher
  9. Ma Q, Wang Y, Zhang T, Zuo W. Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy. Life Sci. 2018;193:104-109 pubmed publisher
  10. Lim J, Ibaseta A, Fischer M, Cancilla B, O Young G, Cristea S, et al. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature. 2017;545:360-364 pubmed publisher
  11. Rippe C, Zhu B, Krawczyk K, Bavel E, Albinsson S, Sjölund J, et al. Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway. Sci Rep. 2017;7:1334 pubmed publisher
  12. Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  13. Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed
  14. Zhang P, He D, Chen Z, Pan Q, Du F, Zang X, et al. Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer. Biochem Pharmacol. 2016;118:18-30 pubmed publisher
  15. Pardo Saganta A, Tata P, Law B, Saez B, Chow R, Prabhu M, et al. Parent stem cells can serve as niches for their daughter cells. Nature. 2015;523:597-601 pubmed publisher
  16. Liu Z, Brunskill E, Varnum Finney B, Zhang C, Zhang A, Jay P, et al. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development. 2015;142:2452-63 pubmed publisher
  17. Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt A, et al. Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies. Oncotarget. 2015;6:21522-32 pubmed
  18. Li X, Tao J, Cigliano A, Sini M, Calderaro J, Azoulay D, et al. Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver. Oncotarget. 2015;6:10102-15 pubmed
  19. Gomi K, Arbelaez V, Crystal R, Walters M. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS ONE. 2015;10:e0116507 pubmed publisher
  20. Plessl K, Haider S, Fiala C, Pollheimer J, Knöfler M. Expression pattern and function of Notch2 in different subtypes of first trimester cytotrophoblast. Placenta. 2015;36:365-71 pubmed publisher
  21. Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher
  22. Dong X, Lin Q, Aihara A, Li Y, Huang C, Chung W, et al. Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype. Oncotarget. 2015;6:1231-48 pubmed
  23. Ortega M, Bhatnagar H, Lin A, Wang L, Aster J, Sill H, et al. A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies. Leukemia. 2015;29:968-76 pubmed publisher
  24. So J, Lin J, Wahler J, Liby K, Sporn M, Suh N. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS ONE. 2014;9:e107616 pubmed publisher
  25. Subramani R, Lopez Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher
  26. Singh A, Zapata M, Choi Y, Yoon S. GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation. Cell Cycle. 2014;13:157-66 pubmed publisher