rat Mfn2 antibody | antibody review based on formal publications

This is a Validated Antibody Database (VAD) review about rat Mfn2, based on 78 published articles (read how Labome selects the articles), using Mfn2 antibody in all methods. It is aimed to help Labome visitors find the most suited Mfn2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.

Mfn2 synonym: HSG

Knockout validation

Abcam mouse monoclonal ab56889	western blot knockout validation; human; 1:500; fig s1b	In order to investigate PINK1-Mfn2-Parkin-mediated mitophagy in mouse hearts, Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot knockout validation on human samples at 1:500 (fig s1b). Science (2015) ncbi
Abcam mouse monoclonal ab56889	western blot knockout validation; mouse; 1:1000; fig s4	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot knockout validation on mouse samples at 1:1000 (fig s4). J Cell Biol (2015) ncbi
Abcam mouse monoclonal ab56889	western blot knockout validation; mouse; 1:1000; fig 1	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1). Cell Metab (2015) ncbi
Cell Signaling Technology domestic rabbit monoclonal (D2D10) 9482	western blot knockout validation; mouse; 1:1000; fig 2c	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot knockout validation on mouse samples at 1:1000 (fig 2c). Nat Commun (2019) ncbi

Abcam

domestic rabbit monoclonal (NIAR164) ab124773	western blot; mouse; 1:500; loading ...; fig 4d	Abcam Mfn2 antibody (Abcam, ab124773) was used in western blot on mouse samples at 1:500 (fig 4d). PLoS ONE (2021) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:1000; loading ...; fig s7b	Abcam Mfn2 antibody (Abcam, Ab56889) was used in western blot on mouse samples at 1:1000 (fig s7b). Cell Death Dis (2021) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:1000; loading ...; fig 3a	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples at 1:1000 (fig 3a). Front Cell Dev Biol (2021) ncbi
mouse monoclonal ab56889	western blot; mouse; loading ...; fig 5a	Abcam Mfn2 antibody (Abcam, 56889) was used in western blot on mouse samples (fig 5a). Aging Cell (2021) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:1000; loading ...; fig 2b	Abcam Mfn2 antibody (AbCAM, ab56889) was used in western blot on mouse samples at 1:1000 (fig 2b). elife (2020) ncbi
mouse monoclonal ab56889	western blot; human; 1:1000; loading ...; fig 3c	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on human samples at 1:1000 (fig 3c). Life Sci Alliance (2020) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:2000; loading ...; fig 6a	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples at 1:2000 (fig 6a). Antioxidants (Basel) (2020) ncbi
mouse monoclonal ab56889	western blot; human; loading ...; fig 2i	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on human samples (fig 2i). Cell Death Differ (2020) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:2000; loading ...	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples at 1:2000. Cell Death Dis (2020) ncbi
domestic rabbit monoclonal (NIAR164) ab124773	western blot; mouse; 1:1000; loading ...; fig 7b	Abcam Mfn2 antibody (Abcam, ab124773) was used in western blot on mouse samples at 1:1000 (fig 7b). Biochem J (2019) ncbi
mouse monoclonal ab56889	western blot; mouse; loading ...; fig s1e	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples (fig s1e). Cell (2019) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:1000; loading ...; fig 5a	Abcam Mfn2 antibody (Abcam, Ab56889) was used in western blot on mouse samples at 1:1000 (fig 5a). Aging Cell (2019) ncbi
mouse monoclonal ab56889	western blot; mouse; loading ...; fig 4a	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples (fig 4a). Cell Rep (2018) ncbi
mouse monoclonal ab56889	western blot; mouse; loading ...; fig s1c	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples (fig s1c). Cell Rep (2018) ncbi
mouse monoclonal ab56889	western blot; human; 1:1000; loading ...; fig 8f	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on human samples at 1:1000 (fig 8f). J Biol Chem (2018) ncbi
mouse monoclonal ab56889	western blot; mouse; loading ...; fig 3c	Abcam Mfn2 antibody (abcam, ab56889) was used in western blot on mouse samples (fig 3c). J Mol Histol (2018) ncbi
domestic rabbit monoclonal (NIAR164) ab124773	western blot; mouse; loading ...; fig 5d	Abcam Mfn2 antibody (Abcam, ab124773) was used in western blot on mouse samples (fig 5d). Cell Death Dis (2018) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:1000; loading ...; fig 2a	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples at 1:1000 (fig 2a). Endocrinology (2018) ncbi
domestic rabbit monoclonal (NIAR164) ab124773	western blot; rat; 1:1000; loading ...; fig 5a	Abcam Mfn2 antibody (Abcam, ab124773) was used in western blot on rat samples at 1:1000 (fig 5a). PLoS ONE (2017) ncbi
mouse monoclonal ab56889	immunohistochemistry; mouse; loading ...; fig 5e western blot; mouse; loading ...; fig 2a western blot; human; loading ...; fig 5c	Abcam Mfn2 antibody (Abcam, 56889) was used in immunohistochemistry on mouse samples (fig 5e), in western blot on mouse samples (fig 2a) and in western blot on human samples (fig 5c). Autophagy (2017) ncbi
mouse monoclonal ab56889	western blot; human; 1:5000; loading ...; fig 2a	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on human samples at 1:5000 (fig 2a). Brain (2017) ncbi
mouse monoclonal ab56889	western blot; mouse; loading ...; fig 4b	In order to evaluate an approach for correcting mitochondrial fusion, Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples (fig 4b). Nature (2016) ncbi
mouse monoclonal ab56889	western blot; mouse; 1:2000; fig 6	In order to study affects of acute minimization of brown adipose tissue function by increased reliance on muscle based thermogenesis, Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples at 1:2000 (fig 6). J Biol Chem (2016) ncbi
mouse monoclonal ab56889	western blot; mouse; fig s4	In order to study inhibition of mitochondrial fragmentation and attenuation of kainic acid-induced hippocampal cell death by a mitochondrial division inhibitor, Mdivi-1, Abcam Mfn2 antibody (Abcam, 56889) was used in western blot on mouse samples (fig s4). BMC Neurosci (2016) ncbi
mouse monoclonal ab56889	western blot; human; fig s1	Abcam Mfn2 antibody (Abcam, 56889) was used in western blot on human samples (fig s1). J Immunol (2016) ncbi
domestic rabbit monoclonal (NIAR164) ab124773	western blot; mouse; fig 1	In order to study protection against acute myocardial infaction via hearts lacking Mfn1 and Mfn2, Abcam Mfn2 antibody (Abcam, ab124773) was used in western blot on mouse samples (fig 1). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal ab50838	western blot; rat; 1:1000; fig 2	In order to elucidate how inhibition of vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation occurs by glucagon-like peptide 1, Abcam Mfn2 antibody (Abcam, ab50838) was used in western blot on rat samples at 1:1000 (fig 2). Biochem Pharmacol (2016) ncbi
mouse monoclonal ab56889	immunocytochemistry; mouse; fig 2 western blot; mouse; fig 4	Abcam Mfn2 antibody (Abcam, ab56889) was used in immunocytochemistry on mouse samples (fig 2) and in western blot on mouse samples (fig 4). Nature (2016) ncbi
mouse monoclonal ab56889	western blot knockout validation; human; 1:500; fig s1b	In order to investigate PINK1-Mfn2-Parkin-mediated mitophagy in mouse hearts, Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot knockout validation on human samples at 1:500 (fig s1b). Science (2015) ncbi
domestic rabbit polyclonal ab50838	western blot; mouse; fig s2	In order to analyze delay of neurodegeneration by preventing stress-induced OPA1 processing in mitochondria by loss of OMA1, Abcam Mfn2 antibody (Abcam, ab50838) was used in western blot on mouse samples (fig s2). J Cell Biol (2016) ncbi
domestic rabbit monoclonal (NIAR164) ab124773	western blot; human; 1:1000; fig 3	In order to determine how mitochondrial homeostasis is affected by ubiquitin-mediated regulation of E3 ligase GP78 by MGRN1 in trans, Abcam Mfn2 antibody (Abcam, ab124773) was used in western blot on human samples at 1:1000 (fig 3). J Cell Sci (2016) ncbi
mouse monoclonal ab56889	flow cytometry; mouse; fig 1h	In order to develop the MitoTimer protein to study individual mitochondria, Abcam Mfn2 antibody (Abcam, ab56889) was used in flow cytometry on mouse samples (fig 1h). J Mol Cell Cardiol (2016) ncbi
mouse monoclonal ab56889	other; mouse; 1:500; fig s4	Abcam Mfn2 antibody (Abcam, ab56889) was used in other on mouse samples at 1:500 (fig s4). Nat Commun (2015) ncbi
mouse monoclonal ab56889	western blot; rat; fig 6d	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on rat samples (fig 6d). Cell Res (2015) ncbi
mouse monoclonal ab56889	western blot; human; fig s1	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on human samples (fig s1). Nat Neurosci (2015) ncbi
mouse monoclonal ab56889	western blot knockout validation; mouse; 1:1000; fig s4	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot knockout validation on mouse samples at 1:1000 (fig s4). J Cell Biol (2015) ncbi
mouse monoclonal ab56889	western blot knockout validation; mouse; 1:1000; fig 1	Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1). Cell Metab (2015) ncbi
mouse monoclonal ab56889	western blot; mouse; fig 3	In order to study how obesity alters mitochondria-associated ER membranes, Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on mouse samples (fig 3). Nat Med (2014) ncbi
mouse monoclonal ab56889	western blot; human; 1:500	In order to report and characterize the interaction between BECN1 and PARK2, Abcam Mfn2 antibody (Abcam, ab56889) was used in western blot on human samples at 1:500. Autophagy (2014) ncbi

Santa Cruz Biotechnology

mouse monoclonal (XX-1) sc-100560	western blot; rat; 1:50; loading ...; fig 5c	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in western blot on rat samples at 1:50 (fig 5c). Aging (Albany NY) (2020) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; rat; fig 3d	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, SC100560) was used in western blot on rat samples (fig 3d). J Cachexia Sarcopenia Muscle (2020) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; human; loading ...; fig 6c	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in western blot on human samples (fig 6c). Dev Cell (2019) ncbi
mouse monoclonal (XX-1) sc-100560	immunohistochemistry; mouse; 1:500; loading ...; fig 1f	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in immunohistochemistry on mouse samples at 1:500 (fig 1f). Cell Death Dis (2018) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; mouse; loading ...; fig 2e	In order to research the role of mTOR in mitochondrial dynamics and cell survival, Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in western blot on mouse samples (fig 2e). Mol Cell (2017) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; human; loading ...; fig 1a western blot; mouse; loading ...; fig 4a	In order to research the protective effect of Mfn2 on dopaminergic neurons, Santa Cruz Biotechnology Mfn2 antibody (SantaCruz, sc-100560) was used in western blot on human samples (fig 1a) and in western blot on mouse samples (fig 4a). Biochim Biophys Acta Mol Basis Dis (2017) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; mouse; loading ...; fig 2g western blot; human; 1:100; loading ...; fig 1b	In order to propose that Mfn2 contributes to cachexia-induced muscle loss, Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in western blot on mouse samples (fig 2g) and in western blot on human samples at 1:100 (fig 1b). Oncol Lett (2016) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; human; loading ...; fig 2a	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz Biotechnology, sc-100560) was used in western blot on human samples (fig 2a). EMBO Mol Med (2016) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; human; 1:1000; fig 4a	Santa Cruz Biotechnology Mfn2 antibody (santa cruz, sc-100560) was used in western blot on human samples at 1:1000 (fig 4a). PLoS ONE (2016) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; human; fig 1a	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz Biotechnology, XX-1) was used in western blot on human samples (fig 1a). J Cell Biol (2016) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; human; fig 1	In order to characterize how dengue virus cleaves mitofusins and impairs mitochondrial fusion, Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in western blot on human samples (fig 1). PLoS Pathog (2015) ncbi
mouse monoclonal (XX-1) sc-100560	western blot; mouse	Santa Cruz Biotechnology Mfn2 antibody (Santa Cruz, sc-100560) was used in western blot on mouse samples . Mol Neurobiol (2014) ncbi

Abnova

mouse monoclonal (6A8) H00009927-M01	western blot; mouse; 1:2000; loading ...; fig s2g	Abnova Mfn2 antibody (Abnova, H00009927-M01) was used in western blot on mouse samples at 1:2000 (fig s2g). Sci Adv (2020) ncbi
mouse monoclonal (4H8) H00009927-M03	western blot; human; loading ...; fig 2c	Abnova Mfn2 antibody (Abnova, H00009927-M03) was used in western blot on human samples (fig 2c). J Cell Biol (2018) ncbi
mouse monoclonal (6A8) H00009927-M01	western blot; human; loading ...; fig 2c	Abnova Mfn2 antibody (Abnova, H00009927-M01) was used in western blot on human samples (fig 2c). J Cell Biol (2018) ncbi
mouse monoclonal (4H8) H00009927-M03	western blot; mouse; loading ...; fig 5j	Abnova Mfn2 antibody (Abnova, H00009927-M03) was used in western blot on mouse samples (fig 5j). Mol Cell (2017) ncbi
mouse monoclonal (6A8) H00009927-M01	western blot; mouse; 1:1000; fig 1a	Abnova Mfn2 antibody (Abnova, H00009927-M01) was used in western blot on mouse samples at 1:1000 (fig 1a). Biochim Biophys Acta Mol Basis Dis (2017) ncbi
mouse monoclonal (4H8) H00009927-M03	western blot; mouse; fig 6	In order to study the independent occurrence of BAK, BAX, and APAF1 from DRP-1 dependent apoptotic mitochondrial fission to amplify cell death by BID and oxidative stress, Abnova Mfn2 antibody (Abnova, H0009927-(MO3)) was used in western blot on mouse samples (fig 6). Biochim Biophys Acta (2016) ncbi
mouse monoclonal (4H8) H00009927-M03	western blot; human	Abnova Mfn2 antibody (Abnova, H00009927-M03) was used in western blot on human samples . J Physiol (2016) ncbi
mouse monoclonal (4H8) H00009927-M03	western blot; human	Abnova Mfn2 antibody (Abnova, H00009927-M03) was used in western blot on human samples . Hum Mol Genet (2015) ncbi
mouse monoclonal (6A8) H00009927-M01	immunohistochemistry; mouse; 1:600	Abnova Mfn2 antibody (Abnova, H00009927-M01) was used in immunohistochemistry on mouse samples at 1:600. PLoS ONE (2014) ncbi

Cell Signaling Technology

domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; 1:1000; loading ...; fig 4n	Cell Signaling Technology Mfn2 antibody (CST, 9482S) was used in western blot on mouse samples at 1:1000 (fig 4n). Front Cardiovasc Med (2021) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; human; 1:500; loading ...; fig 6f western blot; mouse; 1:1000; loading ...; fig 5c	Cell Signaling Technology Mfn2 antibody (CST, D2D10) was used in western blot on human samples at 1:500 (fig 6f) and in western blot on mouse samples at 1:1000 (fig 5c). JCI Insight (2021) ncbi
domestic rabbit monoclonal (D2D10) 9482	immunohistochemistry - paraffin section; human; loading ...; fig s1b	Cell Signaling Technology Mfn2 antibody (Cell signaling, 9482) was used in immunohistochemistry - paraffin section on human samples (fig s1b). Sci Rep (2021) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; loading ...; fig 6c	Cell Signaling Technology Mfn2 antibody (Cell Signaling Technology, 9482) was used in western blot on mouse samples (fig 6c). Cell Death Dis (2020) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; human; fig 5a	Cell Signaling Technology Mfn2 antibody (Cell signaling, 9482) was used in western blot on human samples (fig 5a). Aging Cell (2020) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; loading ...; fig 6d	Cell Signaling Technology Mfn2 antibody (Cell Signaling Technology, 9482) was used in western blot on mouse samples (fig 6d). Oxid Med Cell Longev (2020) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; loading ...; fig 7s1a	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot on mouse samples (fig 7s1a). elife (2019) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; loading ...; fig 4b	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot on mouse samples (fig 4b). Cardiovasc Res (2019) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot knockout validation; mouse; 1:1000; fig 2c	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot knockout validation on mouse samples at 1:1000 (fig 2c). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; 1:1000; loading ...; fig 5a	In order to study the role of succinyl-CoA synthase ADP-forming beta subunit in mtDNA stability and mitochondrial dynamics, Cell Signaling Technology Mfn2 antibody (Cell Signaling Technology, 9482) was used in western blot on mouse samples at 1:1000 (fig 5a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; human; 1:1000; loading ...; fig 3d	Cell Signaling Technology Mfn2 antibody (Cell Signaling, D2D10) was used in western blot on human samples at 1:1000 (fig 3d). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; loading ...; fig 4a	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot on mouse samples (fig 4a). Front Physiol (2016) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse; fig 4	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (D2D10) 9482	immunoprecipitation; human; loading ...; fig 2e western blot; human; loading ...; fig 2e	In order to determine the role of mitophagy in apoptosis induced by oxidized low-density lipoproteins using human vascular smooth muscle cells, Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in immunoprecipitation on human samples (fig 2e) and in western blot on human samples (fig 2e). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D2D10) 9482	immunocytochemistry; mouse; fig 2 western blot; mouse; fig 4	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in immunocytochemistry on mouse samples (fig 2) and in western blot on mouse samples (fig 4). Nature (2016) ncbi
domestic rabbit monoclonal (D2D10) 9482	western blot; mouse	Cell Signaling Technology Mfn2 antibody (Cell Signaling, 9482) was used in western blot on mouse samples . PLoS ONE (2014) ncbi

MilliporeSigma

domestic rabbit polyclonal M6319	western blot; human; loading ...; fig 4a	MilliporeSigma Mfn2 antibody (Sigma, M6319) was used in western blot on human samples (fig 4a). Sci Adv (2021) ncbi
mouse monoclonal (4H8) WH0009927M3	western blot; human; loading ...; fig sf1	In order to research the mechanisms of mitochondrial division, MilliporeSigma Mfn2 antibody (Sigma, WH0009927M3) was used in western blot on human samples (fig sf1). Nature (2016) ncbi
mouse monoclonal (4H8) WH0009927M3	immunocytochemistry; human; 1:1000; fig 4 western blot; human; 1:1000; fig 3	In order to study mitochondrial development, neurogenesis, and synapse formation in human induced pluripotent stem cell-derived cortical neurons, MilliporeSigma Mfn2 antibody (Sigma, WH0009927M3) was used in immunocytochemistry on human samples at 1:1000 (fig 4) and in western blot on human samples at 1:1000 (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (4H8) WH0009927M3	immunohistochemistry - paraffin section; human; loading ...; fig 3b	In order to investigate the contribution of PINK1 and PARKIN to cell death, MilliporeSigma Mfn2 antibody (Sigma-Aldrich, 4H8) was used in immunohistochemistry - paraffin section on human samples (fig 3b). J Biol Chem (2016) ncbi

Articles Reviewed

Huang X, Yan Y, Zheng W, Ma Y, Wang X, Gong W, et al. Secreted Frizzled-Related Protein 5 Protects Against Cardiac Rupture and Improves Cardiac Function Through Inhibiting Mitochondrial Dysfunction. Front Cardiovasc Med. 2021;8:682409 pubmed publisher
Kuroda R, Tominaga K, Kasashima K, Kuroiwa K, Sakashita E, Hayakawa H, et al. Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo. PLoS ONE. 2021;16:e0255355 pubmed publisher
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
Park G, Lee J, Han H, An H, Jin Z, Jeong E, et al. Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death Dis. 2021;12:445 pubmed publisher
Tian F, Zhang Y. Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering. Front Cell Dev Biol. 2021;9:636553 pubmed publisher
Hung C, Lombardo P, Malik N, Brun S, Hellberg K, Van Nostrand J, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021;7: pubmed publisher
Hsiao Y, Shimizu I, Wakasugi T, Yoshida Y, Ikegami R, Hayashi Y, et al. Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy. Sci Rep. 2021;11:6722 pubmed publisher
Niu M, Zhao F, Bondelid K, Siedlak S, Torres S, Fujioka H, et al. VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease. Aging Cell. 2021;20:e13347 pubmed publisher
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
Chiu C, Weng Y, Huang Y, Chen R, Liu Y, Yeh T, et al. (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death Dis. 2020;11:1018 pubmed publisher
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed publisher
Okur M, Fang E, Fivenson E, Tiwari V, Croteau D, Bohr V. Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling. Aging Cell. 2020;19:e13268 pubmed publisher
Sun Q, Chen J, Xu L, Kang J, Wu X, Ren Y, et al. MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model. Oxid Med Cell Longev. 2020;2020:4828256 pubmed publisher
Franco A, Dang X, Walton E, Ho J, Zablocka B, Ly C, et al. Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. elife. 2020;9: pubmed publisher
Rusilowicz Jones E, Jardine J, Kallinos A, Pinto Fernandez A, Guenther F, Giurrandino M, et al. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020;3: pubmed publisher
Meza Torres C, Hernández Camacho J, Cortés Rodríguez A, Fang L, Bui Thanh T, Rodríguez Bies E, et al. Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. Antioxidants (Basel). 2020;9: pubmed publisher
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
Edwards G, Perkins G, Kim K, Kong Y, Lee Y, Choi S, et al. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020;11:254 pubmed publisher
Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
Varuzhanyan G, Rojansky R, Sweredoski M, Graham R, Hess S, Ladinsky M, et al. Mitochondrial fusion is required for spermatogonial differentiation and meiosis. elife. 2019;8: pubmed publisher
Oka S, Chin A, Park J, Ikeda S, Mizushima W, Ralda G, et al. Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart. Cardiovasc Res. 2019;: pubmed publisher
Martínez J, Tarallo D, Martinez Palma L, Victoria S, Bresque M, Rodriguez Bottero S, et al. Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells. Biochem J. 2019;476:2463-2486 pubmed publisher
Chung K, Hsu C, Fan L, Huang Z, Bhatia D, Chen Y, et al. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Commun. 2019;10:3390 pubmed publisher
Hernández Alvarez M, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell. 2019;177:881-895.e17 pubmed publisher
Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisher
Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, et al. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Aging Cell. 2019;18:e12941 pubmed publisher
D Eletto M, Rossin F, Occhigrossi L, Farrace M, Faccenda D, Desai R, et al. Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Rep. 2018;25:3573-3581.e4 pubmed publisher
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed publisher
De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui A, Saha S, et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. J Biol Chem. 2018;293:19740-19760 pubmed publisher
Zhao H, Pan W, Chen L, Luo Y, Xu R. Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation. J Mol Histol. 2018;49:599-613 pubmed publisher
Lin X, Cui M, Xu D, Hong D, Xia Y, Xu C, et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 2018;9:768 pubmed publisher
Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, et al. Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis. 2018;9:105 pubmed publisher
Mattie S, Riemer J, Wideman J, McBride H. A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space. J Cell Biol. 2018;217:507-515 pubmed publisher
Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed publisher
Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur J, Macmillan Crow L. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS ONE. 2017;12:e0185542 pubmed publisher
Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell. 2017;67:922-935.e5 pubmed publisher
Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher
Zhao Y, Tian J, Sui S, Yuan X, Chen H, Qu C, et al. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Sci Rep. 2017;7:7169 pubmed publisher
Zhao F, Wang W, Wang C, Siedlak S, Fujioka H, Tang B, et al. Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1359-1370 pubmed publisher
Wang Q, Wu S, Zhu H, Ding Y, Dai X, Ouyang C, et al. Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L. Autophagy. 2017;13:404-422 pubmed publisher
Caino M, Seo J, Aguinaldo A, Wait E, Bryant K, Kossenkov A, et al. A neuronal network of mitochondrial dynamics regulates metastasis. Nat Commun. 2016;7:13730 pubmed publisher
Guo X, Qi X. VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:552-559 pubmed publisher
Xi Q, Zhang B, Jiang Y, Zhang H, Meng Q, Chen Y, et al. Mitofusin-2 prevents skeletal muscle wasting in cancer cachexia. Oncol Lett. 2016;12:4013-4020 pubmed
Barreto R, Mandili G, Witzmann F, Novelli F, Zimmers T, Bonetto A. Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways. Front Physiol. 2016;7:472 pubmed
Puschmann A, Fiesel F, Caulfield T, Hudec R, Ando M, Truban D, et al. Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism. Brain. 2017;140:98-117 pubmed publisher
Lee J, Westrate L, Wu H, Page C, Voeltz G. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016;540:139-143 pubmed publisher
Franco A, Kitsis R, Fleischer J, Gavathiotis E, Kornfeld O, Gong G, et al. Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature. 2016;540:74-79 pubmed publisher
Fang D, Yan S, Yu Q, Chen D, Yan S. Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons. Sci Rep. 2016;6:31462 pubmed publisher
El Sikhry H, Alsaleh N, Dakarapu R, Falck J, Seubert J. Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. PLoS ONE. 2016;11:e0160380 pubmed publisher
Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, et al. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Mol Med. 2016;8:1019-38 pubmed publisher
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed publisher
Bal N, Maurya S, Singh S, Wehrens X, Periasamy M. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016;291:17247-57 pubmed publisher
Kim H, Lee J, Park K, Kim W, Roh G. A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death. BMC Neurosci. 2016;17:33 pubmed publisher
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
Hall A, Burke N, Dongworth R, Kalkhoran S, Dyson A, Vicencio J, et al. Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction. Cell Death Dis. 2016;7:e2238 pubmed publisher
Swiader A, Nahapetyan H, Faccini J, D Angelo R, Mucher E, Elbaz M, et al. Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Oncotarget. 2016;7:28821-35 pubmed publisher
Oettinghaus B, D Alonzo D, Barbieri E, Restelli L, Savoia C, Licci M, et al. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochim Biophys Acta. 2016;1857:1267-1276 pubmed publisher
Martínez Pizarro A, Desviat L, Ugarte M, Perez B, Richard E. Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects. PLoS ONE. 2016;11:e0150357 pubmed publisher
Otera H, Miyata N, Kuge O, Mihara K. Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling. J Cell Biol. 2016;212:531-44 pubmed publisher
Torres G, Morales P, GarcÃa Miguel M, Norambuena Soto I, Cartes Saavedra B, Vidal PeÃ±a G, et al. Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochem Pharmacol. 2016;104:52-61 pubmed publisher
Luchsinger L, de Almeida M, Corrigan D, Mumau M, Snoeck H. Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential. Nature. 2016;529:528-31 pubmed publisher
Gong G, Song M, Csordás G, Kelly D, Matkovich S, Dorn G. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015;350:aad2459 pubmed publisher
Korwitz A, Merkwirth C, Richter Dennerlein R, TrÃ¶der S, Sprenger H, QuirÃ³s P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
Mukherjee R, Chakrabarti O. Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis. J Cell Sci. 2016;129:757-73 pubmed publisher
Yu C, Liang J, Li J, Lee Y, Chang B, Su C, et al. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog. 2015;11:e1005350 pubmed publisher
Stotland A, Gottlieb R. Î±-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart. J Mol Cell Cardiol. 2016;90:53-8 pubmed publisher
Wu S, Kao C, Wang L, Creighton C, Yang J, Donti T, et al. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015;6:8245 pubmed publisher
Jacobs R, Lundby A, Fenk S, Gehrig S, Siebenmann C, FlÃ¼ck D, et al. Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle. J Physiol. 2016;594:1151-66 pubmed publisher
Wang C, Du W, Su Q, Zhu M, Feng P, Li Y, et al. Dynamic tubulation of mitochondria drives mitochondrial network formation. Cell Res. 2015;25:1108-20 pubmed publisher
Sawyer S, Cheuk Him Ng A, Innes A, Wagner J, Dyment D, Tetreault M, et al. Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy. Hum Mol Genet. 2015;24:5109-14 pubmed publisher
Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, et al. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci. 2015;18:501-10 pubmed publisher
Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, et al. Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol. 2015;208:429-42 pubmed publisher
Song M, Mihara K, Chen Y, Scorrano L, Dorn G. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015;21:273-85 pubmed publisher
Arruda A, Pers B, ParlakgÃ¼l G, GÃ¼ney E, Inouye K, Hotamisligil G. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014;20:1427-35 pubmed publisher
Stacchiotti A, Favero G, Giugno L, Lavazza A, Reiter R, Rodella L, et al. Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. PLoS ONE. 2014;9:e111141 pubmed publisher
Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed publisher
Ost M, Werner F, Dokas J, Klaus S, Voigt A. Activation of AMPK?2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS ONE. 2014;9:e94689 pubmed publisher
Wu Z, Zhu Y, Cao X, Sun S, Zhao B. Mitochondrial toxic effects of A? through mitofusins in the early pathogenesis of Alzheimer's disease. Mol Neurobiol. 2014;50:986-96 pubmed publisher

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