This is a Validated Antibody Database (VAD) review about rat Mdm4, based on 7 published articles (read how Labome selects the articles), using Mdm4 antibody in all methods. It is aimed to help Labome visitors find the most suited Mdm4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Mdm4 synonym: protein Mdm4; Mdm4 p53 binding protein homolog; double minute 4 homolog; double minute 4 protein; mdm2-like p53-binding protein; p53-binding protein Mdm4; protein Mdmx; transformed mouse 3T3 cell double minute 4

Santa Cruz Biotechnology
mouse monoclonal (G-10)
  • western blot; human; 1:500; loading ...; fig 3b
Santa Cruz Biotechnology Mdm4 antibody (Santa Cruz Biotechnology, sc-74467) was used in western blot on human samples at 1:500 (fig 3b). Nat Commun (2018) ncbi
mouse monoclonal (D-4)
  • western blot; mouse; 1:200; fig s4
Santa Cruz Biotechnology Mdm4 antibody (Santa Cruz, sc-74468) was used in western blot on mouse samples at 1:200 (fig s4). Nat Commun (2016) ncbi
mouse monoclonal (A-11)
  • western blot; human; loading ...; fig 3c
Santa Cruz Biotechnology Mdm4 antibody (Santa Cruz, sc-374147) was used in western blot on human samples (fig 3c). Oncogene (2016) ncbi
Proteintech Group
rabbit polyclonal
  • western blot; human
Proteintech Group Mdm4 antibody (Proteintech, 17914-1-AP) was used in western blot on human samples . Cancer Res (2014) ncbi
Sigma-Aldrich
mouse monoclonal (MDMX-82)
  • western blot; human; 1:1000; fig 4
In order to investigate MDM4 exon 6 skipping by antisense oligionucleotides and its affect on inhibiting tumor growth, Sigma-Aldrich Mdm4 antibody (Sigma-Aldrich, MDMX-82) was used in western blot on human samples at 1:1000 (fig 4). J Clin Invest (2016) ncbi
mouse monoclonal (MDMX-82)
  • western blot; mouse
Sigma-Aldrich Mdm4 antibody (Sigma-Aldrich, MDMX82) was used in western blot on mouse samples . Cell Death Dis (2015) ncbi
mouse monoclonal (MDMX-82)
  • immunohistochemistry - paraffin section; human
  • immunoprecipitation; human; 2 ugs
  • western blot; human; fig 6
In order to study the relationship between USP2-MDM4 and p53 in tumorigenesis, Sigma-Aldrich Mdm4 antibody (Sigma, M0445) was used in immunohistochemistry - paraffin section on human samples , in immunoprecipitation on human samples at 2 ugs and in western blot on human samples (fig 6). Carcinogenesis (2014) ncbi
Articles Reviewed
  1. Ng S, Yoshida N, Christie A, Ghandi M, Dharia N, Dempster J, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018;9:2024 pubmed publisher
  2. Riascos Bernal D, Chinnasamy P, Cao L, Dunaway C, Valenta T, Basler K, et al. β-Catenin C-terminal signals suppress p53 and are essential for artery formation. Nat Commun. 2016;7:12389 pubmed publisher
  3. Xie X, Lozano G, Siddik Z. Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene. 2016;35:4798-806 pubmed publisher
  4. Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo S, Low D, et al. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth. J Clin Invest. 2016;126:68-84 pubmed publisher
  5. Yan H, Solozobova V, Zhang P, Armant O, Kuehl B, Brenner Weiss G, et al. p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53. Cell Death Dis. 2015;6:e1662 pubmed publisher
  6. Ling X, Xu C, Fan C, Zhong K, Li F, Wang X. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. Cancer Res. 2014;74:7487-97 pubmed publisher
  7. Wang C, Wang J, Liu Z, Ma X, Wang X, Jin H, et al. Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma. Carcinogenesis. 2014;35:1500-9 pubmed publisher