This is a Validated Antibody Database (VAD) review about rat Lyn, based on 14 published articles (read how Labome selects the articles), using Lyn antibody in all methods. It is aimed to help Labome visitors find the most suited Lyn antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Lyn synonym: p53Lyn; p56Lyn

Santa Cruz Biotechnology
mouse monoclonal (H-6)
  • immunocytochemistry; human; loading ...; fig 3e
  • western blot; human; loading ...; fig 2e
Santa Cruz Biotechnology Lyn antibody (Santa Cruz Biotechnology, sc-7274) was used in immunocytochemistry on human samples (fig 3e) and in western blot on human samples (fig 2e). Biol Open (2019) ncbi
mouse monoclonal (H-6)
  • western blot; human; loading ...; fig s8a
  • western blot; mouse; fig s8a
Santa Cruz Biotechnology Lyn antibody (Santa Cruz, sc-7274) was used in western blot on human samples (fig s8a) and in western blot on mouse samples (fig s8a). Leukemia (2017) ncbi
mouse monoclonal (H-6)
  • western blot; human; fig 3
Santa Cruz Biotechnology Lyn antibody (Santa Cruz, sc-7274) was used in western blot on human samples (fig 3). Oncotarget (2015) ncbi
mouse monoclonal (H-6)
  • western blot; human; fig 1g
Santa Cruz Biotechnology Lyn antibody (Santa, sc-7274) was used in western blot on human samples (fig 1g). J Biol Chem (2014) ncbi
mouse monoclonal (H-6)
  • western blot; human
Santa Cruz Biotechnology Lyn antibody (Santa Cruz Biotechnology, SC-7274) was used in western blot on human samples . Cell Death Dis (2014) ncbi
Abcam
mouse monoclonal (LYN-01)
  • western blot; mouse; fig 5c
  • western blot; human; loading ...; fig 5c
Abcam Lyn antibody (Abcam, ab1890) was used in western blot on mouse samples (fig 5c) and in western blot on human samples (fig 5c). Leukemia (2017) ncbi
mouse monoclonal (LYN-01)
  • western blot; human
Abcam Lyn antibody (Abcam, ab1890) was used in western blot on human samples . Biomed Res Int (2014) ncbi
mouse monoclonal (LYN-01)
  • western blot; mouse; fig 6
Abcam Lyn antibody (Abcam, ab1890) was used in western blot on mouse samples (fig 6). J Immunol (2009) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C13F9)
  • western blot; human; 1:1000; loading ...; fig 5i
Cell Signaling Technology Lyn antibody (Cell Signaling, C13F9) was used in western blot on human samples at 1:1000 (fig 5i). Nat Immunol (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s8a
  • western blot; mouse; fig s8a
Cell Signaling Technology Lyn antibody (Cell Signaling, 2731) was used in western blot on human samples (fig s8a) and in western blot on mouse samples (fig s8a). Leukemia (2017) ncbi
domestic rabbit monoclonal (C13F9)
  • western blot; mouse; 1:1000; loading ...; fig 2a
In order to elucidate the role of SCIMP in Toll-like receptor signaling, Cell Signaling Technology Lyn antibody (Cell Signaling, 2796) was used in western blot on mouse samples at 1:1000 (fig 2a). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2
In order to describe the effects of long- and short-term exposure to erythropoietin on white adipose tissue, Cell Signaling Technology Lyn antibody (Cell signaling, 2731) was used in western blot on human samples (fig 2). Lipids Health Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2
In order to describe the effects of long- and short-term exposure to erythropoietin on white adipose tissue, Cell Signaling Technology Lyn antibody (Cell signaling, 2732) was used in western blot on human samples (fig 2). Lipids Health Dis (2016) ncbi
domestic rabbit monoclonal (C13F9)
  • western blot; mouse; fig 7
In order to determine the response threshold of immunoreceptor tyrosine-based activation motifs, Cell Signaling Technology Lyn antibody (Cell Signaling, 2796) was used in western blot on mouse samples (fig 7). elife (2015) ncbi
domestic rabbit monoclonal (C13F9)
  • western blot; human; 0.015 ug/ml; fig 4
  • western blot; mouse; 0.015 ug/ml; fig s3
In order to analyze breast cancer liver metastasis and how Lyn modulates Claudin-2 expression as a therapeutic target, Cell Signaling Technology Lyn antibody (Cell Signaling Technology, 2796) was used in western blot on human samples at 0.015 ug/ml (fig 4) and in western blot on mouse samples at 0.015 ug/ml (fig s3). Oncotarget (2015) ncbi
domestic rabbit monoclonal (C13F9)
  • western blot; mouse; fig 2b
Cell Signaling Technology Lyn antibody (Cell Signaling, C13F9) was used in western blot on mouse samples (fig 2b). Nature (2015) ncbi
domestic rabbit monoclonal (C13F9)
  • western blot; human
In order to study how phosphorylation alters COP1-binding sites of oncoproteins, Cell Signaling Technology Lyn antibody (Cell Signaling, 2796) was used in western blot on human samples . Cancer Cell (2014) ncbi
Articles Reviewed
  1. Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed publisher
  2. Xiong X, Lee C, Li W, Yu J, Zhu L, Kim Y, et al. Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins. Biol Open. 2019;: pubmed publisher
  3. Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, et al. Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia. 2017;31:1502-1512 pubmed publisher
  4. Luo L, Bokil N, Wall A, Kapetanovic R, Lansdaal N, Marceline F, et al. SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nat Commun. 2017;8:14133 pubmed publisher
  5. Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
  6. Amigo Jiménez I, Bailón E, Aguilera Montilla N, Terol M, García Marco J, García Pardo A. Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways. Oncotarget. 2015;6:44832-48 pubmed publisher
  7. Freedman T, Tan Y, Skrzypczynska K, Manz B, Sjaastad F, Goodridge H, et al. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. elife. 2015;4: pubmed publisher
  8. Tabariès S, Annis M, Hsu B, Tam C, Savage P, Park M, et al. Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis. Oncotarget. 2015;6:9476-87 pubmed
  9. Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
  10. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014;26:222-34 pubmed publisher
  11. Caliceti C, Zambonin L, Rizzo B, Fiorentini D, Vieceli Dalla Sega F, Hrelia S, et al. Role of plasma membrane caveolae/lipid rafts in VEGF-induced redox signaling in human leukemia cells. Biomed Res Int. 2014;2014:857504 pubmed publisher
  12. Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, et al. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 2014;289:12313-29 pubmed publisher
  13. Liu L, Wen Q, Gong R, Gilles L, Stankiewicz M, Guo M, et al. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Cell Death Dis. 2014;5:e988 pubmed publisher
  14. Gross A, Lyandres J, Panigrahi A, Prak E, DeFranco A. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009;182:5382-92 pubmed publisher