This is a Validated Antibody Database (VAD) review about rat Lrp1, based on 19 published articles (read how Labome selects the articles), using Lrp1 antibody in all methods. It is aimed to help Labome visitors find the most suited Lrp1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Lrp1 synonym: LRP-1

Knockout validation
MilliporeSigma
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; fig s1e
MilliporeSigma Lrp1 antibody (Sigma, L2295) was used in western blot knockout validation on human samples at 1:1000 (fig s1e). Nature (2020) ncbi
Abcam
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse
Abcam Lrp1 antibody (Abcam, EPR3724) was used in western blot on mouse samples . Adv Sci (Weinh) (2021) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse
Abcam Lrp1 antibody (Abcam, EPR3724) was used in western blot on mouse samples . Alzheimers Res Ther (2021) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry; human; 1:200; loading ...; fig 6c
Abcam Lrp1 antibody (Abcam, ab92544) was used in immunohistochemistry on human samples at 1:200 (fig 6c). Acta Neuropathol (2020) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunocytochemistry; human; 1:200; loading ...; fig 4a
  • western blot; human; 1:2000; loading ...; fig 4b
Abcam Lrp1 antibody (Abcam, ab92544) was used in immunocytochemistry on human samples at 1:200 (fig 4a) and in western blot on human samples at 1:2000 (fig 4b). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; 1:1000; loading ...; fig 2j
Abcam Lrp1 antibody (Abcam, ab92544) was used in western blot on mouse samples at 1:1000 (fig 2j). CNS Neurosci Ther (2020) ncbi
domestic rabbit monoclonal (EPR3724)
  • other; mouse; loading ...; fig 4f
  • immunocytochemistry; mouse; loading ...; fig 5a
Abcam Lrp1 antibody (Abcam, ab195567) was used in other on mouse samples (fig 4f) and in immunocytochemistry on mouse samples (fig 5a). J Exp Med (2019) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; human; loading ...; fig 4a
Abcam Lrp1 antibody (Abcam, ab92544) was used in western blot on human samples (fig 4a). Cell Rep (2018) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4d
Abcam Lrp1 antibody (Abcam, ab92544) was used in immunohistochemistry on mouse samples at 1:500 (fig 4d). Brain Behav Immun (2018) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; loading ...; fig s1a
Abcam Lrp1 antibody (Abcam, ab92544) was used in western blot on mouse samples (fig s1a). Arterioscler Thromb Vasc Biol (2018) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; loading ...; fig s5d
Abcam Lrp1 antibody (Abcam, ab92544) was used in western blot on mouse samples (fig s5d). PLoS Genet (2017) ncbi
domestic rabbit monoclonal (EPR3724)
  • blocking or activating experiments; rat; loading ...; fig 3g
In order to elucidate the regulation and function of enzymatically inactive heparanase, Abcam Lrp1 antibody (Abcam, ab92544) was used in blocking or activating experiments on rat samples (fig 3g). Cardiovasc Res (2016) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; fig  1
Abcam Lrp1 antibody (Epitomics, 2703-1) was used in western blot on mouse samples (fig  1). J Mol Cell Cardiol (2015) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse
Abcam Lrp1 antibody (Epitomics, 2703-1) was used in western blot on mouse samples . J Neuroinflammation (2014) ncbi
Invitrogen
domestic rabbit recombinant (SA0290)
  • immunohistochemistry; mouse; 1:300; loading ...
Invitrogen Lrp1 antibody (Thermo Fisher, MA5-31959) was used in immunohistochemistry on mouse samples at 1:300. Nat Commun (2021) ncbi
mouse monoclonal (A2MR-beta-1)
  • western blot; human; fig 3
In order to report that heat shock protein-90alpha allows cancer cells to survive hypoxia, Invitrogen Lrp1 antibody (Life Technologies, 37?C7600) was used in western blot on human samples (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (A2MR-beta-1)
  • western blot; human
In order to elucidate a role for heat shock proteins in ischemia, Invitrogen Lrp1 antibody (Life Technologies, 37-7600) was used in western blot on human samples . J Cell Sci (2015) ncbi
mouse monoclonal (A2MR-beta-1)
  • immunoprecipitation; human; fig 4
  • western blot; human; fig 4
In order to elucidate the mechanism by which eHsp90alpha regulates promotility action, Invitrogen Lrp1 antibody (Invitrogen, 37-7600) was used in immunoprecipitation on human samples (fig 4) and in western blot on human samples (fig 4). Mol Cell Biol (2013) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; fig s1e
MilliporeSigma Lrp1 antibody (Sigma, L2295) was used in western blot knockout validation on human samples at 1:1000 (fig s1e). Nature (2020) ncbi
mouse monoclonal (LRP1-11)
  • immunocytochemistry; human; 1:200; fig s7
  • western blot; human; 1:1000; fig s7
MilliporeSigma Lrp1 antibody (Sigma, L2420) was used in immunocytochemistry on human samples at 1:200 (fig s7) and in western blot on human samples at 1:1000 (fig s7). Nat Commun (2015) ncbi
Articles Reviewed
  1. Dai X, Jiang Y, Gu J, Jiang Z, Wu Y, Yu C, et al. The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Adv Sci (Weinh). 2021;8:2003636 pubmed publisher
  2. Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher
  3. He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Möller Hackbarth K, et al. Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun. 2021;12:2141 pubmed publisher
  4. Rauch J, Luna G, Guzman E, Audouard M, Challis C, Sibih Y, et al. LRP1 is a master regulator of tau uptake and spread. Nature. 2020;580:381-385 pubmed publisher
  5. Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher
  6. Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher
  7. Zhang R, Liu Y, Chen Y, Li Q, Marshall C, Wu T, et al. Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption. CNS Neurosci Ther. 2020;26:228-239 pubmed publisher
  8. Weckbach L, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, et al. Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. J Exp Med. 2019;216:350-368 pubmed publisher
  9. Leslie P, Franklin D, Liu Y, Zhang Y. p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell Rep. 2018;24:1484-1495 pubmed publisher
  10. Storck S, Hartz A, Bernard J, Wolf A, Kachlmeier A, Mahringer A, et al. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain Behav Immun. 2018;73:21-33 pubmed publisher
  11. Yu P, Xiong T, Tenedero C, Lebeau P, Ni R, Macdonald M, et al. Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering. Arterioscler Thromb Vasc Biol. 2018;38:26-39 pubmed publisher
  12. Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher
  13. Wang F, Jia J, Lal N, Zhang D, Chiu A, Wan A, et al. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res. 2016;112:656-668 pubmed
  14. Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, YING Q, et al. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016;6:20605 pubmed publisher
  15. Chaumet A, Wright G, Seet S, Tham K, Gounko N, Bard F. Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. Nat Commun. 2015;6:8218 pubmed publisher
  16. Revuelta López E, Cal R, Herraiz Martínez A, De Gonzalo Calvo D, Nasarre L, Roura S, et al. Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes. J Mol Cell Cardiol. 2015;85:25-36 pubmed publisher
  17. Jayaprakash P, Dong H, Zou M, Bhatia A, O Brien K, Chen M, et al. Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci. 2015;128:1475-80 pubmed publisher
  18. Niesman I, Schilling J, Shapiro L, Kellerhals S, Bonds J, Kleschevnikov A, et al. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014;11:39 pubmed publisher
  19. Tsen F, Bhatia A, O Brien K, Cheng C, Chen M, Hay N, et al. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013;33:4947-59 pubmed publisher