This is a Validated Antibody Database (VAD) review about rat Lck, based on 19 published articles (read how Labome selects the articles), using Lck antibody in all methods. It is aimed to help Labome visitors find the most suited Lck antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Lck synonym: Lck1; Lcktkr; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte-specific protein tyrosine kinase; p56-LCK

Santa Cruz Biotechnology
mouse monoclonal (3A5)
  • western blot; mouse; loading ...; fig 6a
Santa Cruz Biotechnology Lck antibody (Santa, sc-433) was used in western blot on mouse samples (fig 6a). Nat Immunol (2018) ncbi
mouse monoclonal (3A5)
  • western blot; human; loading ...; fig s7
Santa Cruz Biotechnology Lck antibody (SantaCruz, 3A5) was used in western blot on human samples (fig s7). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (3A5)
  • western blot; human; loading ...; fig 3c
Santa Cruz Biotechnology Lck antibody (Santa Cruz, SC-433) was used in western blot on human samples (fig 3c). Redox Biol (2017) ncbi
mouse monoclonal (3A5)
  • immunocytochemistry; human; loading ...; fig 1a
Santa Cruz Biotechnology Lck antibody (Santa Cruz, 3A5) was used in immunocytochemistry on human samples (fig 1a). J Immunol (2016) ncbi
mouse monoclonal (3A5)
  • flow cytometry; human; fig 1c
Santa Cruz Biotechnology Lck antibody (SantaCruz, 3A5) was used in flow cytometry on human samples (fig 1c). J Virol (2016) ncbi
mouse monoclonal (3A5)
  • immunocytochemistry; human; fig 4
Santa Cruz Biotechnology Lck antibody (Santa Cruz, sc-433) was used in immunocytochemistry on human samples (fig 4). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (3A5)
  • western blot; human; loading ...; fig 3a
In order to test if the two hematopoietic systems in patients with mixed chimerism remain functional and study immunological differences, Santa Cruz Biotechnology Lck antibody (Santa Cruz, 3A5) was used in western blot on human samples (fig 3a). PLoS ONE (2016) ncbi
mouse monoclonal (3A5)
  • western blot; mouse; fig 5
Santa Cruz Biotechnology Lck antibody (Santa Cruz, 3A5) was used in western blot on mouse samples (fig 5). J Exp Med (2016) ncbi
mouse monoclonal (3A5)
  • western blot; mouse; fig 6
Santa Cruz Biotechnology Lck antibody (Santa Cruz, sc-433) was used in western blot on mouse samples (fig 6). Oncogene (2016) ncbi
mouse monoclonal (3A5)
  • western blot; mouse; fig s4
Santa Cruz Biotechnology Lck antibody (santa Cruz, sc-433) was used in western blot on mouse samples (fig s4). Front Cell Neurosci (2015) ncbi
mouse monoclonal (3A5)
  • western blot; mouse; fig 6a
Santa Cruz Biotechnology Lck antibody (Santa Cruz Biotechnology, 3A5) was used in western blot on mouse samples (fig 6a). J Exp Med (2015) ncbi
mouse monoclonal (3A5)
  • western blot; mouse; fig 1
Santa Cruz Biotechnology Lck antibody (Santa Cruz, sc-433) was used in western blot on mouse samples (fig 1). PLoS ONE (2015) ncbi
mouse monoclonal (3A5)
  • western blot; human; loading ...; fig 1c
Santa Cruz Biotechnology Lck antibody (Santa Cruz, sc-433) was used in western blot on human samples (fig 1c). PLoS ONE (2014) ncbi
mouse monoclonal (3A5)
  • western blot; human; fig 3
In order to show that CKIP-1 interacts with CARMA1 and inhibits PKCtheta-CBM-NF-kappaB signaling, Santa Cruz Biotechnology Lck antibody (Santa, sc-433) was used in western blot on human samples (fig 3). PLoS ONE (2014) ncbi
mouse monoclonal (3A5)
  • western blot; human
Santa Cruz Biotechnology Lck antibody (Santa Cruz Biotechnology, 3A5) was used in western blot on human samples . Mol Cell Biol (2014) ncbi
mouse monoclonal (3A5)
  • western blot; human
Santa Cruz Biotechnology Lck antibody (Santa Cruz, 3A5) was used in western blot on human samples . J Immunol (2013) ncbi
mouse monoclonal (3A5)
  • western blot; human; fig 1
Santa Cruz Biotechnology Lck antibody (Santa Cruz, sc-433) was used in western blot on human samples (fig 1). BMC Immunol (2009) ncbi
BD Biosciences
mouse monoclonal (28/Lck)
  • western blot; human; loading ...; fig 4a
In order to report the proteome of CADA-treated SUP-T1 human CD4+ T lymphocytes, BD Biosciences Lck antibody (BD Biosciences, 28) was used in western blot on human samples (fig 4a). Mol Cell Proteomics (2017) ncbi
mouse monoclonal (4/LCK-Y505)
  • flow cytometry; human
In order to study NK function in solid tumors, BD Biosciences Lck antibody (BD Biosciences, 4/LCK-Y505) was used in flow cytometry on human samples . Int J Cancer (2014) ncbi
Articles Reviewed
  1. Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley L, et al. Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol. 2018;19:594-605 pubmed publisher
  2. Li L, Guo X, Shi X, Li C, Wu W, Yan C, et al. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. 2017;114:E5891-E5899 pubmed publisher
  3. Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed publisher
  4. Van Puyenbroeck V, Claeys E, Schols D, Bell T, Vermeire K. A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics. 2017;16:157-167 pubmed publisher
  5. Silva J, Martins N, Henriques R, Soares H. HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse. J Immunol. 2016;197:4042-4052 pubmed
  6. Trautz B, Pierini V, Wombacher R, Stolp B, Chase A, Pizzato M, et al. The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor. J Virol. 2016;90:10915-10927 pubmed publisher
  7. Pageon S, Tabarin T, Yamamoto Y, Ma Y, Nicovich P, Bridgeman J, et al. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci U S A. 2016;113:E5454-63 pubmed publisher
  8. Stikvoort A, Sundin M, Uzunel M, Gertow J, Sundberg B, Schaffer M, et al. Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?. PLoS ONE. 2016;11:e0154737 pubmed publisher
  9. Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed publisher
  10. Franciosa G, Diluvio G, Gaudio F, Giuli M, Palermo R, Grazioli P, et al. Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression. Oncogene. 2016;35:4741-51 pubmed publisher
  11. De Mario A, Castellani A, Peggion C, Massimino M, Lim D, Hill A, et al. The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase. Front Cell Neurosci. 2015;9:416 pubmed publisher
  12. Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Jie Z, et al. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015;212:1323-36 pubmed publisher
  13. Silva O, Crocetti J, Humphries L, Burkhardt J, Miceli M. Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells. PLoS ONE. 2015;10:e0133353 pubmed publisher
  14. Baens M, Bonsignore L, Somers R, Vanderheydt C, Weeks S, Gunnarsson J, et al. MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes. PLoS ONE. 2014;9:e103774 pubmed publisher
  15. Prinz P, Mendler A, Brech D, Masouris I, Oberneder R, Noessner E. NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention. Int J Cancer. 2014;135:1832-41 pubmed publisher
  16. Sakamoto T, Kobayashi M, Tada K, Shinohara M, Io K, Nagata K, et al. CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1. PLoS ONE. 2014;9:e85762 pubmed publisher
  17. Kloog Y, Mor A. Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1. Mol Cell Biol. 2014;34:978-88 pubmed publisher
  18. Paster W, Brockmeyer C, Fu G, Simister P, de Wet B, Martinez Riaño A, et al. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol. 2013;190:3749-56 pubmed publisher
  19. Ngai J, Inngjerdingen M, Berge T, Tasken K. Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. BMC Immunol. 2009;10:27 pubmed publisher