This is a Validated Antibody Database (VAD) review about rat Kv2 1, based on 13 published articles (read how Labome selects the articles), using Kv2 1 antibody in all methods. It is aimed to help Labome visitors find the most suited Kv2 1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Kv2 1 synonym: DRK1PC; Kcr1-1; Kv2.1; Shab

Knockout validation
Neuromab
mouse monoclonal (K89/34)
  • immunohistochemistry knockout validation; mouse; 1:1000; loading ...; fig 2a
Neuromab Kv2 1 antibody (NeuroMab, 75-014) was used in immunohistochemistry knockout validation on mouse samples at 1:1000 (fig 2a). Int J Mol Sci (2021) ncbi
Neuromab
mouse monoclonal (K89/34)
  • immunohistochemistry knockout validation; mouse; 1:1000; loading ...; fig 2a
Neuromab Kv2 1 antibody (NeuroMab, 75-014) was used in immunohistochemistry knockout validation on mouse samples at 1:1000 (fig 2a). Int J Mol Sci (2021) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry; rat; fig 1c
Neuromab Kv2 1 antibody (NeuroMab, 73-014) was used in immunohistochemistry on rat samples (fig 1c). Mol Biol Cell (2018) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry; mouse; loading ...; fig 2a
Neuromab Kv2 1 antibody (NeuroMab, 73-014) was used in immunohistochemistry on mouse samples (fig 2a). Front Mol Neurosci (2018) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry - frozen section; mouse; 1:100; fig 2b
  • western blot; mouse; fig 3a
Neuromab Kv2 1 antibody (NeuroMab, K89/34) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 2b) and in western blot on mouse samples (fig 3a). J Neurosci (2016) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry; mouse; 1:1000; fig 1
Neuromab Kv2 1 antibody (Neuromab, 75-014) was used in immunohistochemistry on mouse samples at 1:1000 (fig 1). Front Neuroanat (2016) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry; mouse; 1:250; fig 1
In order to study neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons by Neuregulin 1, Neuromab Kv2 1 antibody (NeuroMab, K89/34) was used in immunohistochemistry on mouse samples at 1:250 (fig 1). Acta Neuropathol Commun (2016) ncbi
mouse monoclonal (K89/34)
  • western blot; mouse; fig 2
Neuromab Kv2 1 antibody (NeuroMab, K89/34) was used in western blot on mouse samples (fig 2). J Neurosci (2015) ncbi
mouse monoclonal (K89/34)
  • western blot; mouse; fig 4
Neuromab Kv2 1 antibody (NeuroMab, K89/34) was used in western blot on mouse samples (fig 4). Nat Commun (2015) ncbi
mouse monoclonal (K89/34)
  • western blot; mouse; 1:2
In order to assess if impaired voltage-gated K(+) channel function contributes to arterial tone during diabetes, Neuromab Kv2 1 antibody (NeuroMab, 73-014) was used in western blot on mouse samples at 1:2. J Biol Chem (2015) ncbi
mouse monoclonal (K89/34)
  • immunocytochemistry; mouse; 1:400; fig 6
Neuromab Kv2 1 antibody (NeuroMab, 75-014) was used in immunocytochemistry on mouse samples at 1:400 (fig 6). J Neurosci (2015) ncbi
mouse monoclonal (K89/34)
  • western blot; human; 1:500
In order to discuss the role of increasing copy number of variants in neurodevelopmental disorders, Neuromab Kv2 1 antibody (NeuroMab, K89/34) was used in western blot on human samples at 1:500. Ann Neurol (2014) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry - free floating section; mouse; fig 1
In order to study Kv2.1 expression and phosphorylation, Neuromab Kv2 1 antibody (NeuroMab, 73-014) was used in immunohistochemistry - free floating section on mouse samples (fig 1). J Comp Neurol (2014) ncbi
mouse monoclonal (K89/34)
  • immunohistochemistry - free floating section; rat; 10 ug/ml
In order to study Kv2.1 function and membrane excitability in the axon initial segment, Neuromab Kv2 1 antibody (NeuroMab, 75-014) was used in immunohistochemistry - free floating section on rat samples at 10 ug/ml. J Comp Neurol (2014) ncbi
Articles Reviewed
  1. Jiang X, Rashwan R, Voigt V, NERBONNE J, Hunt D, Carvalho L. Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1. Int J Mol Sci. 2021;22: pubmed publisher
  2. Kirmiz M, Palacio S, Thapa P, King A, Sack J, Trimmer J. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Mol Biol Cell. 2018;29:2410-2432 pubmed publisher
  3. Bishop H, Cobb M, Kirmiz M, Parajuli L, Mandikian D, Philp A, et al. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons. Front Mol Neurosci. 2018;11:1 pubmed publisher
  4. Yu W, Parakramaweera R, Teng S, Gowda M, Sharad Y, Thakker Varia S, et al. Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. J Neurosci. 2016;36:11084-11096 pubmed
  5. Vereczki V, Veres J, Müller K, Nagy G, Rácz B, Barsy B, et al. Synaptic Organization of Perisomatic GABAergic Inputs onto the Principal Cells of the Mouse Basolateral Amygdala. Front Neuroanat. 2016;10:20 pubmed publisher
  6. Lasiene J, Komine O, Fujimori Tonou N, Powers B, Endo F, Watanabe S, et al. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Acta Neuropathol Commun. 2016;4:15 pubmed publisher
  7. Bishop H, Guan D, Bocksteins E, Parajuli L, Murray K, Cobb M, et al. Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons. J Neurosci. 2015;35:14922-42 pubmed publisher
  8. Vullhorst D, Mitchell R, Keating C, Roychowdhury S, Karavanova I, Tao Cheng J, et al. A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling. Nat Commun. 2015;6:7222 pubmed publisher
  9. Nieves Cintrón M, Nystoriak M, Prada M, Johnson K, Fayer W, Dell Acqua M, et al. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015;290:7918-29 pubmed publisher
  10. Medalla M, Luebke J. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015;35:112-27 pubmed publisher
  11. Torkamani A, Bersell K, Jorge B, Bjork R, Friedman J, Bloss C, et al. De novo KCNB1 mutations in epileptic encephalopathy. Ann Neurol. 2014;76:529-540 pubmed publisher
  12. Mandikian D, Bocksteins E, Parajuli L, Bishop H, Cerda O, Shigemoto R, et al. Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors. J Comp Neurol. 2014;522:3555-74 pubmed publisher
  13. King A, Manning C, Trimmer J. A unique ion channel clustering domain on the axon initial segment of mammalian neurons. J Comp Neurol. 2014;522:2594-608 pubmed publisher