This is a Validated Antibody Database (VAD) review about rat Keap1, based on 19 published articles (read how Labome selects the articles), using Keap1 antibody in all methods. It is aimed to help Labome visitors find the most suited Keap1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Keap1 synonym: Inrf2

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D6B12)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling Tech, 8047) was used in western blot knockout validation on human samples (fig 6a). Animals (Basel) (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6B12)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling Tech, 8047) was used in western blot knockout validation on human samples (fig 6a). BMC Cancer (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6B12)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling Tech, 8047) was used in western blot knockout validation on human samples (fig 6a). Aging (Albany NY) (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6B12)
  • western blot; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology Keap1 antibody (CST, 8047S) was used in western blot on mouse samples at 1:1000 (fig 4b). Front Pharmacol (2021) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; human; 1:1000; loading ...; fig 5j, 5m
Cell Signaling Technology Keap1 antibody (CST, 8047) was used in western blot on human samples at 1:1000 (fig 5j, 5m). J Cell Mol Med (2021) ncbi
domestic rabbit polyclonal
  • western blot; rat; 1:1000; loading ...; fig 6c
Cell Signaling Technology Keap1 antibody (Cell Signaling Technology, 4678) was used in western blot on rat samples at 1:1000 (fig 6c). Front Pharmacol (2021) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling Tech, 8047) was used in western blot knockout validation on human samples (fig 6a). Animals (Basel) (2021) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling Tech, 8047) was used in western blot knockout validation on human samples (fig 6a). BMC Cancer (2021) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot knockout validation; human; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling Tech, 8047) was used in western blot knockout validation on human samples (fig 6a). Aging (Albany NY) (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Cell Signaling Technology Keap1 antibody (Cell Signaling Technology, 4617) was used in western blot on human samples . Nat Commun (2020) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; mouse; 1:1000; loading ...; fig 8b
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047) was used in western blot on mouse samples at 1:1000 (fig 8b). Front Pharmacol (2019) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; human; loading ...; fig s2k
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047) was used in western blot on human samples (fig s2k). Cell (2019) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; mouse; 1:1000; loading ...; fig 3i
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047) was used in western blot on mouse samples at 1:1000 (fig 3i). Biochem Biophys Res Commun (2018) ncbi
domestic rabbit monoclonal (D1G10)
  • western blot; human; loading ...; fig 1e
Cell Signaling Technology Keap1 antibody (Cell signaling, D1G10) was used in western blot on human samples (fig 1e). Science (2018) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; human; 1:1000; loading ...; fig 2f, 2h
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047S) was used in western blot on human samples at 1:1000 (fig 2f, 2h). EMBO J (2018) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; human; loading ...; fig 1A; 1B
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047) was used in western blot on human samples (fig 1A; 1B). Oncotarget (2017) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; human; 1:1000; loading ...; fig 2f
In order to identify and characterize an inhibitor of the COP9 signalosome, Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047) was used in western blot on human samples at 1:1000 (fig 2f). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; rat; fig 3
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047) was used in western blot on rat samples (fig 3). Sci Rep (2016) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; human; fig 2a
Cell Signaling Technology Keap1 antibody (Cell-Signaling, 8047) was used in western blot on human samples (fig 2a). Free Radic Biol Med (2015) ncbi
domestic rabbit monoclonal (D1G10)
  • western blot; human; fig s7
Cell Signaling Technology Keap1 antibody (Cell Signaling, 7705S) was used in western blot on human samples (fig s7). Mol Cancer Res (2015) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; mouse; fig 6a
Cell Signaling Technology Keap1 antibody (Cell Signaling, D6B12) was used in western blot on mouse samples (fig 6a). J Biol Chem (2015) ncbi
domestic rabbit monoclonal (D6B12)
  • western blot; rat; 1:1000
Cell Signaling Technology Keap1 antibody (Cell Signaling, 8047S) was used in western blot on rat samples at 1:1000. PLoS ONE (2014) ncbi
Articles Reviewed
  1. Li S, Jin H, Sun G, Zhang C, Wang J, Xu H, et al. Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress. Front Pharmacol. 2021;12:634115 pubmed publisher
  2. Hu J, Wang J, Li C, Shang Y. Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway. J Cell Mol Med. 2021;25:5001-5014 pubmed publisher
  3. Zhou F, Zou X, Zhang J, Wang Z, Yang Y, Wang D. Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats. Front Pharmacol. 2021;12:630210 pubmed publisher
  4. Strous E, Vanhoudt A, Smolenaars A, van Schaik G, Schouten M, de Pater H, et al. Observational Study on Variation of Longitudinal Platelet Counts in Calves over the First 14 Days of Life and Reference Intervals from Cross-Sectional Platelet and Leukocyte Counts in Dairy Calves up to Two Months of Age. Animals (Basel). 2021;11: pubmed publisher
  5. Xi Y, Jing Z, Wei W, Chun Z, Quan Q, Qing Z, et al. Inhibitory effect of sodium butyrate on colorectal cancer cells and construction of the related molecular network. BMC Cancer. 2021;21:127 pubmed publisher
  6. Huang D, Dai C, Li S, Li X. Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury. Aging (Albany NY). 2021;13:11010-11025 pubmed publisher
  7. Brockway S, Wang G, Jackson J, Amici D, Takagishi S, Clutter M, et al. Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq. Nat Commun. 2020;11:5722 pubmed publisher
  8. Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y. Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function. Front Pharmacol. 2019;10:1354 pubmed publisher
  9. Sanghvi V, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, et al. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell. 2019;178:807-819.e21 pubmed publisher
  10. Li C, Liu Q, Xie L. Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress. Biochem Biophys Res Commun. 2018;507:22-29 pubmed publisher
  11. Mena E, Kjolby R, Saxton R, Werner A, Lew B, Boyle J, et al. Dimerization quality control ensures neuronal development and survival. Science. 2018;362: pubmed publisher
  12. Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher
  13. Cheng L, Li K, Yi N, Li X, Wang F, Xue B, et al. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. Oncotarget. 2017;8:13186-13194 pubmed publisher
  14. Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher
  15. Ashino T, Yamamoto M, Numazawa S. Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep. 2016;6:26291 pubmed publisher
  16. Kabaria S, Choi D, Chaudhuri A, Jain M, Li H, Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic Biol Med. 2015;89:548-56 pubmed publisher
  17. Dorr C, Janik C, Weg M, Been R, Bader J, Kang R, et al. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Mol Cancer Res. 2015;13:1238-47 pubmed publisher
  18. Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher
  19. Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, Banerjee S. Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS ONE. 2014;9:e94228 pubmed publisher