This is a Validated Antibody Database (VAD) review about rat Jak1, based on 35 published articles (read how Labome selects the articles), using Jak1 antibody in all methods. It is aimed to help Labome visitors find the most suited Jak1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Abcam
domestic rabbit monoclonal (EPR349(N))
  • western blot; human; loading ...; fig 6a
Abcam Jak1 antibody (Abcam, ab133666) was used in western blot on human samples (fig 6a). Cell Mol Biol Lett (2020) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig s6
  • western blot; human; loading ...; fig 4k, 4o
Invitrogen Jak1 antibody (Invitrogen, PA5- 86682) was used in immunohistochemistry - paraffin section on human samples (fig s6) and in western blot on human samples (fig 4k, 4o). J Immunother Cancer (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (73)
  • western blot; human
Santa Cruz Biotechnology Jak1 antibody (Santa Cruz Biotechnology, sc- 136225) was used in western blot on human samples . Viral Immunol (2014) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s3b
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3332S) was used in western blot on human samples (fig s3b). Nat Cancer (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s7c
  • western blot; human; loading ...; fig 5a, s7d
Cell Signaling Technology Jak1 antibody (CST, 3331S) was used in western blot on mouse samples (fig s7c) and in western blot on human samples (fig 5a, s7d). J Clin Invest (2022) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 5a, s7d
  • western blot; mouse; loading ...; fig s7c
Cell Signaling Technology Jak1 antibody (CST, 3344S) was used in western blot on human samples (fig 5a, s7d) and in western blot on mouse samples (fig s7c). J Clin Invest (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3e
Cell Signaling Technology Jak1 antibody (CST, 3332) was used in western blot on mouse samples at 1:1000 (fig 3e). Nat Commun (2022) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples (fig 1f). Int J Med Sci (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3331) was used in western blot on human samples (fig 1f). Int J Med Sci (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 3h
  • western blot; human; 1:1000; loading ...; fig 3g, 3i
Cell Signaling Technology Jak1 antibody (CST, 3331) was used in western blot on mouse samples at 1:1000 (fig 3h) and in western blot on human samples at 1:1000 (fig 3g, 3i). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 6c
Cell Signaling Technology Jak1 antibody (Cell signaling, 3344) was used in western blot on human samples (fig 6c). Cell Rep (2021) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; mouse; fig 4d
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on mouse samples (fig 4d). Nat Commun (2021) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; mouse; loading ...; fig 1c
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 6G4) was used in western blot on mouse samples (fig 1c). Nat Commun (2020) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3344) was used in western blot on human samples (fig 1f). Int J Mol Sci (2020) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 6G4) was used in western blot on human samples (fig 4c). J Exp Clin Cancer Res (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1c
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 1c). Cell Stem Cell (2019) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; 1:1000; loading ...; fig 4a
Cell Signaling Technology Jak1 antibody (Cell Signaling, 6G4) was used in western blot on human samples at 1:1000 (fig 4a). Br J Cancer (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3d
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 3d). Cancer Discov (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 1f). Cell (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3332) was used in western blot on mouse samples (fig 1f). Cell (2018) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; mouse; 1:500; loading ...; fig 4e
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3344) was used in western blot on mouse samples at 1:500 (fig 4e). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology Jak1 antibody (Cell Signaling Technologies, 3332) was used in western blot on human samples (fig 1b). Oncoimmunology (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 9a
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on human samples (fig 9a). Nature (2017) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 3e
Cell Signaling Technology Jak1 antibody (Cell signaling, 3344) was used in western blot on human samples (fig 3e). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3a
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on human samples at 1:1000 (fig 3a). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5a
Cell Signaling Technology Jak1 antibody (cell signalling, 3331) was used in western blot on human samples (fig 5a). PLoS Med (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s8
In order to find that that vascular endothelial growth factor 165b prevents activation of vascular endothelial growth factor receptor 1-STAT3 signaling by vascular endothelial growth factor 165a, Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig s8). Circ Res (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (6G4)
  • immunoprecipitation; mouse; loading ...; fig 4
  • western blot; mouse; loading ...; fig 4
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Cell Signaling Technology Jak1 antibody (Cell Signaling, 3344) was used in immunoprecipitation on mouse samples (fig 4) and in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; loading ...; fig s4
Cell Signaling Technology Jak1 antibody (cell signalling, 3331) was used in western blot on human samples at 1:200 (fig s4). Oncotarget (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig s4
Cell Signaling Technology Jak1 antibody (cell signalling, 3332) was used in western blot on human samples at 1:500 (fig s4). Oncotarget (2017) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; mouse; 1:2000; loading ...; fig 9a
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on mouse samples at 1:2000 (fig 9a). Drug Des Devel Ther (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 9a
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3331) was used in western blot on mouse samples at 1:1000 (fig 9a). Drug Des Devel Ther (2016) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; mouse; fig 6c
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 6G4) was used in western blot on mouse samples (fig 6c). J Exp Med (2016) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 6G4) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 3g
  • western blot; human; loading ...; fig 3f
Cell Signaling Technology Jak1 antibody (Cell Signaling, 3331) was used in immunohistochemistry on mouse samples (fig 3g) and in western blot on human samples (fig 3f). J Clin Invest (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 7a
In order to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways, Cell Signaling Technology Jak1 antibody (Cell Signaling Technologies, 3332) was used in western blot on mouse samples at 1:500 (fig 7a). Nat Commun (2016) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; fig 4
Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human; 1:1000; fig 4
In order to analyze multidrug resistant human cancer cells and autocrime cytokine/JAK/STAT-signaling induces kynurenin synthesis, Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples at 1:1000 (fig 4). PLoS ONE (2015) ncbi
domestic rabbit monoclonal (6G4)
  • western blot; human
In order to show that uPAR regulates nasopharyngeal carcinoma NPC progression, Cell Signaling Technology Jak1 antibody (Cell Signaling Technology, 3344) was used in western blot on human samples . Cell Cycle (2014) ncbi
BD Biosciences
mouse monoclonal (73/JAK1)
  • western blot; human; 1:1000; loading ...; fig 3a
BD Biosciences Jak1 antibody (BD Biosciences, 610231) was used in western blot on human samples at 1:1000 (fig 3a). Nat Commun (2016) ncbi
mouse monoclonal (73/JAK1)
  • western blot; human; loading ...; fig 3f
  • western blot; mouse; loading ...; fig 3a
BD Biosciences Jak1 antibody (BD Biosciences, 610231) was used in western blot on human samples (fig 3f) and in western blot on mouse samples (fig 3a). J Clin Invest (2016) ncbi
mouse monoclonal (73/JAK1)
  • western blot; human; 0.25 ug/ml
In order to evaluate the effect of JAK1/2 inhibitor AZD1480 on IL-6-induced experimental prostate cancer metastases formation, BD Biosciences Jak1 antibody (BD Biosciences, 610231) was used in western blot on human samples at 0.25 ug/ml. Mol Cancer Ther (2014) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 8
MilliporeSigma Jak1 antibody (Sigma, SAB4504446) was used in immunohistochemistry - paraffin section on human samples (fig 8). J Clin Invest (2016) ncbi
Articles Reviewed
  1. Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson N, et al. Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Nat Cancer. 2022;3:1071-1087 pubmed publisher
  2. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, et al. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. J Clin Invest. 2022;132: pubmed publisher
  3. Liu H, He J, Bagheri Yarmand R, Li Z, Liu R, Wang Z, et al. Osteocyte CIITA aggravates osteolytic bone lesions in myeloma. Nat Commun. 2022;13:3684 pubmed publisher
  4. Han J, Chen X, Xu J, Chu L, Li R, Sun N, et al. Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1. Int J Med Sci. 2021;18:3437-3451 pubmed publisher
  5. Xu P, Xiong W, Lin Y, Fan L, Pan H, Li Y. Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression. Cell Death Dis. 2021;12:779 pubmed publisher
  6. Sun Y, Jing J, Xu H, Xu L, Hu H, Tang C, et al. N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells. J Immunother Cancer. 2021;9: pubmed publisher
  7. Wang H, Hou W, Perera A, Bettler C, Beach J, Ding X, et al. Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Cell Rep. 2021;34:108765 pubmed publisher
  8. Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed publisher
  9. Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed publisher
  10. Ding H, Zhang X, Su Y, Jia C, Dai C. GNAS promotes inflammation-related hepatocellular carcinoma progression by promoting STAT3 activation. Cell Mol Biol Lett. 2020;25:8 pubmed publisher
  11. Hindupur S, Schmid S, Koch J, Youssef A, Baur E, Wang D, et al. STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy. Int J Mol Sci. 2020;21: pubmed publisher
  12. Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt M, Hermanns H, et al. IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression. J Exp Clin Cancer Res. 2019;38:397 pubmed publisher
  13. Wang E, Dai Z, Ferrante A, Drake C, Christiano A. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019;: pubmed publisher
  14. Martin V, Chiriaco C, Modica C, Acquadro A, Cortese M, Galimi F, et al. Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours. Br J Cancer. 2019;120:527-536 pubmed publisher
  15. Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  16. Xu X, Xu J, Wu J, Hu Y, Han Y, Gu Y, et al. Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response. Cell. 2018;175:1336-1351.e17 pubmed publisher
  17. Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  18. Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher
  19. Patel S, Sanjana N, Kishton R, Eidizadeh A, Vodnala S, Cam M, et al. Identification of essential genes for cancer immunotherapy. Nature. 2017;548:537-542 pubmed publisher
  20. Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed publisher
  21. Eletto D, Burns S, Angulo I, Plagnol V, Gilmour K, Henriquez F, et al. Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection. Nat Commun. 2016;7:13992 pubmed publisher
  22. Li Y, Buijs Gladdines J, Cant Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed publisher
  23. Ganta V, Choi M, Kutateladze A, Annex B. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circ Res. 2017;120:282-295 pubmed publisher
  24. Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  25. Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget. 2017;8:1304-1320 pubmed publisher
  26. He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  27. Textor A, Schmidt K, Kloetzel P, Weißbrich B, Perez C, Charo J, et al. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2016;213:2333-2348 pubmed
  28. Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher
  29. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, et al. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest. 2016;126:2064-76 pubmed publisher
  30. O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
  31. Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  32. Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE. 2015;10:e0126159 pubmed publisher
  33. Liu Y, Zhang Z, Zhao X, Yu R, Zhang X, Wu S, et al. Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression. Viral Immunol. 2014;27:267-76 pubmed publisher
  34. Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed publisher
  35. Gu L, Talati P, Vogiatzi P, Romero Weaver A, Abdulghani J, Liao Z, et al. Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation. Mol Cancer Ther. 2014;13:1246-58 pubmed publisher