This is a Validated Antibody Database (VAD) review about rat Htt, based on 48 published articles (read how Labome selects the articles), using Htt antibody in all methods. It is aimed to help Labome visitors find the most suited Htt antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Htt synonym: Hd; Hdh

Knockout validation
Abcam
domestic rabbit monoclonal (EPR5526)
  • western blot knockout validation; mouse; loading ...; fig 3c
Abcam Htt antibody (Abcam, EPR5526) was used in western blot knockout validation on mouse samples (fig 3c). Proc Natl Acad Sci U S A (2016) ncbi
EMD Millipore
mouse monoclonal (1HU-4C8)
  • western blot knockout validation; mouse; loading ...; fig 1b
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot knockout validation on mouse samples (fig 1b). Proc Natl Acad Sci U S A (2016) ncbi
Abcam
domestic rabbit monoclonal (EPR5526)
  • western blot; mouse; 1:5000; loading ...; fig 5b
Abcam Htt antibody (Abcam, ab109115) was used in western blot on mouse samples at 1:5000 (fig 5b). PLoS Genet (2017) ncbi
domestic rabbit monoclonal (EPR5526)
  • western blot; mouse; 1:3000; loading ...; fig 3c
In order to discuss regulation of mutant huntingtin by transcription factor EB, Abcam Htt antibody (Abcam, EPR5526) was used in western blot on mouse samples at 1:3000 (fig 3c). J Huntingtons Dis (2016) ncbi
domestic rabbit monoclonal (EPR5526)
  • western blot; mouse; 1:3000; loading ...; fig 6a
In order to test if increased NUB1 protein levels reduces mutant huntingtin levels through a proteasome dependent mechanism, Abcam Htt antibody (Abcam, EPR5526) was used in western blot on mouse samples at 1:3000 (fig 6a). J Huntingtons Dis (2016) ncbi
domestic rabbit monoclonal (EPR5526)
  • western blot knockout validation; mouse; loading ...; fig 3c
Abcam Htt antibody (Abcam, EPR5526) was used in western blot knockout validation on mouse samples (fig 3c). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (EP867Y)
  • flow cytometry; mouse; fig s1
Abcam Htt antibody (Abcam, EP867Y) was used in flow cytometry on mouse samples (fig s1). Sci Rep (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D7F7)
  • western blot; mouse; 1:1000; loading ...; fig ev1c
Cell Signaling Technology Htt antibody (Cell signaling, D7F7) was used in western blot on mouse samples at 1:1000 (fig ev1c). EMBO Mol Med (2020) ncbi
domestic rabbit monoclonal (D7F7)
  • western blot; human; 1:1000; loading ...; fig 1b
Cell Signaling Technology Htt antibody (Cell Signaling, D7F7) was used in western blot on human samples at 1:1000 (fig 1b). PLoS ONE (2016) ncbi
EMD Millipore
mouse monoclonal (1HU-4C8)
  • ELISA; mouse; 4 ug/ml; loading ...; fig 4b
  • western blot; human; 1:500; loading ...; fig 1g
EMD Millipore Htt antibody (Millipore, MAB2166) was used in ELISA on mouse samples at 4 ug/ml (fig 4b) and in western blot on human samples at 1:500 (fig 1g). Nat Med (2019) ncbi
mouse monoclonal (1HU-4C8)
  • immunocytochemistry; human; 1:500; loading ...; fig 4b
EMD Millipore Htt antibody (Millipore, MAB2166) was used in immunocytochemistry on human samples at 1:500 (fig 4b). Neurochem Int (2018) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; fig s5e
EMD Millipore Htt antibody (Chemicon, Mab2166) was used in western blot on mouse samples (fig s5e). Nat Commun (2017) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human; 1:1000; loading ...; fig 6a
In order to demonstrate the protective effects of an oligomer-specific single-chain variable fragment antibody in Parkinson's disease and Huntington's disease mouse models, EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on human samples at 1:1000 (fig 6a). Sci Rep (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:1000; loading ...; fig 2c
In order to investigate the impact of locked nucleic acid-modified antisense oligonucleotide complementary to the CAG repeat on Huntington's disease, EMD Millipore Htt antibody (EMD Millipore, MAB2166) was used in western blot on mouse samples at 1:1000 (fig 2c). J Clin Invest (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:1000; fig 1c
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:1000 (fig 1c). Nat Commun (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:3000; loading ...; fig s3a
EMD Millipore Htt antibody (Millipore, mAb2166) was used in western blot on mouse samples at 1:3000 (fig s3a). J Clin Invest (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:1000; loading ...; fig 6a
In order to test if increased NUB1 protein levels reduces mutant huntingtin levels through a proteasome dependent mechanism, EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:1000 (fig 6a). J Huntingtons Dis (2016) ncbi
mouse monoclonal (1HU-4C8)
  • immunohistochemistry - paraffin section; mouse; 1:500; fig s2
EMD Millipore Htt antibody (Millipore, MAB2166) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig s2). Sci Rep (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot knockout validation; mouse; loading ...; fig 1b
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot knockout validation on mouse samples (fig 1b). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:1000; loading ...; fig 1a
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:1000 (fig 1a). J Huntingtons Dis (2016) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; rat; fig s7
EMD Millipore Htt antibody (Chemicon, MAB2166) was used in western blot on rat samples (fig s7). Autophagy (2015) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; fig 4
EMD Millipore Htt antibody (Millipore, MAB 2166) was used in western blot on mouse samples (fig 4). EMBO Mol Med (2015) ncbi
mouse monoclonal (1HU-4C8)
  • flow cytometry; mouse
  • western blot; mouse; 1:2000; loading ...; fig 3b
EMD Millipore Htt antibody (Millipore, MAB2166) was used in flow cytometry on mouse samples and in western blot on mouse samples at 1:2000 (fig 3b). Sci Rep (2015) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:200; fig 2
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:200 (fig 2). Dis Model Mech (2015) ncbi
mouse monoclonal (1HU-4C8)
  • immunoprecipitation; mouse
  • western blot; mouse; 1:1000
  • immunoprecipitation; human
  • western blot; human; 1:1000
In order to assess transgenic mice expressing different forms of huntingtin protein for disease, EMD Millipore Htt antibody (Millipore, MAB2166) was used in immunoprecipitation on mouse samples , in western blot on mouse samples at 1:1000, in immunoprecipitation on human samples and in western blot on human samples at 1:1000. J Biol Chem (2015) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; fig 4
EMD Millipore Htt antibody (Chemicon, MAB2166) was used in western blot on mouse samples (fig 4). PLoS Genet (2015) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:1000; fig 1
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:1000 (fig 1). elife (2015) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse
EMD Millipore Htt antibody (EMD Milliporeon, MAB2166) was used in western blot on mouse samples . Dev Biol (2015) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human
EMD Millipore Htt antibody (Millipore, 1HU-4C8) was used in western blot on human samples . Dis Model Mech (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:2000
EMD Millipore Htt antibody (Chemicon, MAB2166) was used in western blot on mouse samples at 1:2000. J Huntingtons Dis (2012) ncbi
mouse monoclonal (1HU-4C8)
  • immunohistochemistry - paraffin section; human; 1:150
EMD Millipore Htt antibody (Millipore, MAB2166) was used in immunohistochemistry - paraffin section on human samples at 1:150. PLoS ONE (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human; 1:10000
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on human samples at 1:10000. PLoS ONE (2014) ncbi
mouse monoclonal (1HU-4C8)
  • immunohistochemistry - paraffin section; human; 1:500
In order to investigate the association of eosinophilic neuronal cytoplasmic inclusions with stress granules and autophagy in two clinical cases, EMD Millipore Htt antibody (Millipore, 1HU-4C8) was used in immunohistochemistry - paraffin section on human samples at 1:500. Neuropathology (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human; 1:1000; fig 6
EMD Millipore Htt antibody (EMD Millipore, MAB2166) was used in western blot on human samples at 1:1000 (fig 6). Ann Neurol (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human; 1:1000
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on human samples at 1:1000. PLoS Curr (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; African green monkey; 1:1000
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on African green monkey samples at 1:1000. PLoS ONE (2014) ncbi
mouse monoclonal (1HU-4C8)
  • immunohistochemistry - paraffin section; human; 1:200
EMD Millipore Htt antibody (Chemicon, MAB2166) was used in immunohistochemistry - paraffin section on human samples at 1:200. Neuropathol Appl Neurobiol (2014) ncbi
mouse monoclonal (1HU-4C8)
  • immunoprecipitation; human
  • western blot; human
EMD Millipore Htt antibody (Chemicon, 2166) was used in immunoprecipitation on human samples and in western blot on human samples . J Biol Chem (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human
EMD Millipore Htt antibody (Chemicon, mAB 2166) was used in western blot on human samples . PLoS ONE (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse
In order to investigate the role of huntingtin in the the regulation of autophagosome dynamics, EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples . J Neurosci (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human; 1:1,000
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on human samples at 1:1,000. Nucleic Acid Ther (2014) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:2000
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:2000. PLoS ONE (2013) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on human samples . Biochemistry (2013) ncbi
mouse monoclonal (1HU-4C8)
  • immunoprecipitation; human
EMD Millipore Htt antibody (Millipore, MAB2166) was used in immunoprecipitation on human samples . Cell Rep (2013) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human
EMD Millipore Htt antibody (Chemicon Millipore, MAB2166) was used in western blot on human samples . Nucleic Acids Res (2013) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples . J Huntingtons Dis (2012) ncbi
mouse monoclonal (1HU-4C8)
  • immunohistochemistry - paraffin section; mouse; 1:50
EMD Millipore Htt antibody (Chemicon / Millipore, MAB2166) was used in immunohistochemistry - paraffin section on mouse samples at 1:50. J Comp Neurol (2013) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; mouse; 1:250
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on mouse samples at 1:250. Mitochondrion (2013) ncbi
mouse monoclonal (1HU-4C8)
  • immunohistochemistry; rat
  • western blot; rat
EMD Millipore Htt antibody (Millipore, MAB2166) was used in immunohistochemistry on rat samples and in western blot on rat samples . Antioxid Redox Signal (2013) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; rat; 1:2,500
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on rat samples at 1:2,500. Mol Pharm (2013) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human; 1:2000
  • western blot; rat; 1:2000
EMD Millipore Htt antibody (Millipore, MAB2166) was used in western blot on human samples at 1:2000 and in western blot on rat samples at 1:2000. J Neurosci (2012) ncbi
mouse monoclonal (1HU-4C8)
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human; fig 5c
EMD Millipore Htt antibody (Chemicon, MAB2166) was used in immunoprecipitation on human samples , in immunocytochemistry on human samples and in western blot on human samples (fig 5c). PLoS ONE (2012) ncbi
mouse monoclonal (1HU-4C8)
  • western blot; human
EMD Millipore Htt antibody (Chemicon, MAB2166) was used in western blot on human samples . Nucleic Acids Res (2012) ncbi
Articles Reviewed
  1. Ehinger Y, Bruyère J, Panayotis N, Abada Y, Borloz E, Matagne V, et al. Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice. EMBO Mol Med. 2020;12:e10889 pubmed publisher
  2. Zeitler B, Froelich S, Marlen K, Shivak D, Yu Q, Li D, et al. Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease. Nat Med. 2019;25:1131-1142 pubmed publisher
  3. Vidoni C, Secomandi E, Castiglioni A, Melone M, Isidoro C. Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation. Neurochem Int. 2018;117:174-187 pubmed publisher
  4. Gómez Pastor R, Burchfiel E, Neef D, Jaeger A, Cabiscol E, McKinstry S, et al. Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease. Nat Commun. 2017;8:14405 pubmed publisher
  5. Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, et al. Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction. PLoS Genet. 2017;13:e1006578 pubmed publisher
  6. Zha J, Liu X, Zhu J, Liu S, Lu S, Xu P, et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep. 2016;6:36631 pubmed publisher
  7. Rue L, Bañez Coronel M, Creus Muncunill J, Giralt A, Alcalá Vida R, Mentxaka G, et al. Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels. J Clin Invest. 2016;126:4319-4330 pubmed publisher
  8. Vodicka P, Chase K, Iuliano M, Tousley A, Valentine D, Sapp E, et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:249-260 pubmed
  9. Guo X, Sun X, Hu D, Wang Y, Fujioka H, Vyas R, et al. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun. 2016;7:12646 pubmed publisher
  10. Kratter I, Zahed H, Lau A, Tsvetkov A, Daub A, Weiberth K, et al. Serine 421 regulates mutant huntingtin toxicity and clearance in mice. J Clin Invest. 2016;126:3585-97 pubmed publisher
  11. Vodicka P, Chase K, Iuliano M, Valentine D, Sapp E, Lu B, et al. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:163-74 pubmed publisher
  12. Lewis M, Buniello A, Hilton J, Zhu F, Zhang W, Evans S, et al. Exploring regulatory networks of miR-96 in the developing inner ear. Sci Rep. 2016;6:23363 pubmed publisher
  13. Wang G, Liu X, Gaertig M, Li S, Li X. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A. 2016;113:3359-64 pubmed publisher
  14. Culver B, DeClercq J, Dolgalev I, Yu M, Ma B, Heguy A, et al. Huntington's Disease Protein Huntingtin Associates with its own mRNA. J Huntingtons Dis. 2016;5:39-51 pubmed publisher
  15. Lopes C, Aubert S, Bourgois Rocha F, Barnat M, Rego A, Déglon N, et al. Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells. PLoS ONE. 2016;11:e0148680 pubmed publisher
  16. Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher
  17. Hwang S, Disatnik M, Mochly Rosen D. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med. 2015;7:1307-26 pubmed publisher
  18. Southwell A, Smith S, Davis T, Caron N, Villanueva E, Xie Y, et al. Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression. Sci Rep. 2015;5:12166 pubmed publisher
  19. Szlachcic W, Switonski P, Krzyzosiak W, Figlerowicz M, Figiel M. Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway. Dis Model Mech. 2015;8:1047-57 pubmed publisher
  20. O Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring K, Zhang N, et al. Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. J Biol Chem. 2015;290:19287-306 pubmed publisher
  21. Cheng H, Chern Y, Chen I, Liu C, Li S, Chun S, et al. Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown. PLoS Genet. 2015;11:e1005043 pubmed publisher
  22. Yao Y, Cui X, Al Ramahi I, Sun X, Li B, Hou J, et al. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. elife. 2015;4: pubmed publisher
  23. Sanders S, Hou J, Sutton L, Garside V, Mui K, Singaraja R, et al. Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development. Dev Biol. 2015;397:257-66 pubmed publisher
  24. Brandstaetter H, Kruppa A, Buss F. Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane. Dis Model Mech. 2014;7:1335-40 pubmed publisher
  25. Graham R, Deng Y, Pouladi M, Vaid K, Ehrnhoefer D, Southwell A, et al. Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo. J Huntingtons Dis. 2012;1:243-60 pubmed publisher
  26. Simeone P, Trerotola M, Urbanella A, Lattanzio R, Ciavardelli D, Di Giuseppe F, et al. A unique four-hub protein cluster associates to glioblastoma progression. PLoS ONE. 2014;9:e103030 pubmed publisher
  27. Macdonald D, Tessari M, Boogaard I, Smith M, Pulli K, Szynol A, et al. Quantification assays for total and polyglutamine-expanded huntingtin proteins. PLoS ONE. 2014;9:e96854 pubmed publisher
  28. Mori F, Watanabe Y, Miki Y, Tanji K, Odagiri S, Eto K, et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases. Neuropathology. 2014;34:140-7 pubmed
  29. Cicchetti F, Lacroix S, Cisbani G, Vallières N, Saint Pierre M, St Amour I, et al. Mutant huntingtin is present in neuronal grafts in Huntington disease patients. Ann Neurol. 2014;76:31-42 pubmed publisher
  30. An M, O Brien R, Zhang N, Patra B, de la Cruz M, Ray A, et al. Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System. PLoS Curr. 2014;6: pubmed publisher
  31. Sanders S, Mui K, Sutton L, Hayden M. Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L. PLoS ONE. 2014;9:e90669 pubmed publisher
  32. Schiffer D, Caldera V, Mellai M, Conforti P, Cattaneo E, Zuccato C. Repressor element-1 silencing transcription factor (REST) is present in human control and Huntington's disease neurones. Neuropathol Appl Neurobiol. 2014;40:899-910 pubmed publisher
  33. Marion S, Urs N, Peterson S, Sotnikova T, Beaulieu J, Gainetdinov R, et al. Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein. J Biol Chem. 2014;289:11715-24 pubmed publisher
  34. Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed publisher
  35. Wong Y, Holzbaur E. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J Neurosci. 2014;34:1293-305 pubmed publisher
  36. Evers M, Tran H, Zalachoras I, Meijer O, den Dunnen J, van Ommen G, et al. Preventing formation of toxic N-terminal huntingtin fragments through antisense oligonucleotide-mediated protein modification. Nucleic Acid Ther. 2014;24:4-12 pubmed publisher
  37. Baldo B, Soylu R, Petersen A. Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction. PLoS ONE. 2013;8:e83050 pubmed publisher
  38. Aiba Y, Hu J, Liu J, Xiang Q, Martinez C, Corey D. Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions. Biochemistry. 2013;52:9329-38 pubmed publisher
  39. Sbodio J, Paul B, Machamer C, Snyder S. Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease. Cell Rep. 2013;4:890-7 pubmed publisher
  40. Liu J, Pendergraff H, Narayanannair K, Lackey J, Kuchimanchi S, Rajeev K, et al. RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression. Nucleic Acids Res. 2013;41:8788-801 pubmed publisher
  41. Strong M, Southwell A, Yonan J, Hayden M, MacGregor G, Thompson L, et al. Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background. J Huntingtons Dis. 2012;1:221-41 pubmed publisher
  42. Milman P, Woulfe J. Novel variant of neuronal intranuclear rodlet immunoreactive for 40 kDa huntingtin associated protein and ubiquitin in the mouse brain. J Comp Neurol. 2013;521:3832-46 pubmed publisher
  43. Silva A, Almeida S, Laço M, Duarte A, Domingues J, Oliveira C, et al. Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers. Mitochondrion. 2013;13:801-9 pubmed publisher
  44. Haun F, Nakamura T, Shiu A, Cho D, Tsunemi T, Holland E, et al. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal. 2013;19:1173-84 pubmed publisher
  45. Godinho B, Ogier J, Darcy R, O Driscoll C, Cryan J. Self-assembling modified ?-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease. Mol Pharm. 2013;10:640-9 pubmed publisher
  46. Yu Taeger L, Petrasch Parwez E, Osmand A, Redensek A, Metzger S, Clemens L, et al. A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease. J Neurosci. 2012;32:15426-38 pubmed publisher
  47. Qi L, Zhang X, Wu J, Lin F, Wang J, DiFiglia M, et al. The role of chaperone-mediated autophagy in huntingtin degradation. PLoS ONE. 2012;7:e46834 pubmed publisher
  48. Hu J, Liu J, Yu D, Chu Y, Corey D. Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway. Nucleic Acids Res. 2012;40:11270-80 pubmed publisher