This is a Validated Antibody Database (VAD) review about rat Hmgcr, based on 16 published articles (read how Labome selects the articles), using Hmgcr antibody in all methods. It is aimed to help Labome visitors find the most suited Hmgcr antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Hmgcr synonym: 3H3M

Abcam
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; 1:500; loading ...; fig 2e
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on mouse samples at 1:500 (fig 2e). Nat Commun (2021) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; loading ...; fig s4f
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on mouse samples (fig s4f). iScience (2021) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; 1:1000; loading ...; fig s4a
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on mouse samples at 1:1000 (fig s4a). Mol Ther Nucleic Acids (2021) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; loading ...; fig 2
Abcam Hmgcr antibody (abcam, Ab174830) was used in western blot on mouse samples (fig 2). Int J Mol Sci (2020) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; human; loading ...; fig 4e
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on human samples (fig 4e). Biomolecules (2019) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; loading ...; fig 1b
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on mouse samples (fig 1b). EMBO J (2019) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; loading ...; fig 2a
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on mouse samples (fig 2a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; loading ...; fig 3a
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on mouse samples (fig 3a). Int J Mol Med (2016) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; mouse; fig 5
Abcam Hmgcr antibody (AbCam, ab174830) was used in western blot on mouse samples (fig 5). J Lipid Res (2016) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • western blot; human; loading ...; fig s1c
Abcam Hmgcr antibody (Abcam, ab174830) was used in western blot on human samples (fig s1c). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (EPR1685(N))
  • immunohistochemistry - frozen section; mouse; 1:50; fig 8
In order to elucidate the mechanisms by which increased LMNB1 levels cause autosomal dominant leukodystrophy, Abcam Hmgcr antibody (Abcam, ab174830) was used in immunohistochemistry - frozen section on mouse samples at 1:50 (fig 8). J Neurosci (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (C-1)
  • western blot; human; loading ...; fig 2c
Santa Cruz Biotechnology Hmgcr antibody (Santa Cruz, sc-271595) was used in western blot on human samples (fig 2c). Cell Death Dis (2019) ncbi
mouse monoclonal (C-1)
  • western blot; mouse; loading ...; fig 5e
Santa Cruz Biotechnology Hmgcr antibody (Santa, sc-271595) was used in western blot on mouse samples (fig 5e). Cell (2019) ncbi
mouse monoclonal (C-1)
  • western blot; human; fig 1
Santa Cruz Biotechnology Hmgcr antibody (Santa Cruz, sc-271595) was used in western blot on human samples (fig 1). Cell Death Dis (2015) ncbi
mouse monoclonal (C-1)
  • western blot; human; 1:1000; fig 3
Santa Cruz Biotechnology Hmgcr antibody (santa Cruz, sc-271595) was used in western blot on human samples at 1:1000 (fig 3). Oncotarget (2015) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2k
Invitrogen Hmgcr antibody (Thermo Fisher Scientific, PA5-37367) was used in western blot on mouse samples (fig 2k). Cell (2019) ncbi
Articles Reviewed
  1. Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, et al. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021;12:3005 pubmed publisher
  2. Li Y, Chen L, Li L, Sottas C, Petrillo S, Lazaris A, et al. Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021;24:102457 pubmed publisher
  3. Zhang Z, Wen H, Peng B, Weng J, Zeng F. HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. Mol Ther Nucleic Acids. 2021;24:711-727 pubmed publisher
  4. Kim Y, Oh S, Ahn J, Yook J, Kim C, Park S, et al. The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia. Int J Mol Sci. 2020;21: pubmed publisher
  5. Yu H, Rimbert A, Palmer A, Toyohara T, Xia Y, Xia F, et al. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell. 2019;179:1276-1288.e14 pubmed publisher
  6. Zhou L, Wang Q, Zhang H, Li Y, Xie S, Xu M. YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine. Biomolecules. 2019;9: pubmed publisher
  7. Su L, Zhou L, Chen F, Wang H, Qian H, Sheng Y, et al. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 2019;38: pubmed publisher
  8. Göbel A, Breining D, Rauner M, Hofbauer L, Rachner T. Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells. Cell Death Dis. 2019;10:91 pubmed publisher
  9. Moon S, Huang C, Houlihan S, Regunath K, Freed Pastor W, Morris J, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019;176:564-580.e19 pubmed publisher
  10. Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher
  11. Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher
  12. Tao W, Moore R, Meng Y, Smith E, Xu X. Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol. J Lipid Res. 2016;57:809-17 pubmed publisher
  13. Sharma M, Tuaine J, McLaren B, Waters D, Black K, Jones L, et al. Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells. PLoS ONE. 2016;11:e0148049 pubmed publisher
  14. Laezza C, D Alessandro A, Di Croce L, Picardi P, Ciaglia E, Pisanti S, et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. Cell Death Dis. 2015;6:e1909 pubmed publisher
  15. Rolyan H, Tyurina Y, Hernandez M, Amoscato A, Sparvero L, Nmezi B, et al. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015;35:12002-17 pubmed publisher
  16. Sharon C, Baranwal S, Patel N, Rodriguez Agudo D, Pandak W, Majumdar A, et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. Oncotarget. 2015;6:15332-47 pubmed