This is a Validated Antibody Database (VAD) review about rat Hk2, based on 33 published articles (read how Labome selects the articles), using Hk2 antibody in all methods. It is aimed to help Labome visitors find the most suited Hk2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Invitrogen
domestic rabbit polyclonal
  • western blot; human; 1:2000; loading ...; fig 4d
Invitrogen Hk2 antibody (Life Technologies, PA5-29326) was used in western blot on human samples at 1:2000 (fig 4d). Cell (2019) ncbi
domestic rabbit monoclonal (H.738.7)
  • western blot; human; loading ...; fig 1
In order to elucidate the role of hexokinases in colorectal cancer growth, Invitrogen Hk2 antibody (Thermo Fisher, MA5-14849) was used in western blot on human samples (fig 1). BMC Genet (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; Russian wild horse; fig 2
In order to find that the expression of HK2 is significantly greater during the progesterone-dominated phase of the cycle, Invitrogen Hk2 antibody (Thermo Fisher Scientific, PA5-29326) was used in immunohistochemistry - paraffin section on Russian wild horse samples (fig 2). Reprod Biol Endocrinol (2017) ncbi
Abnova
mouse monoclonal (4H1)
  • western blot; human; fig 3
In order to investigate MAPK14-driven metabolic reprogramming, Abnova Hk2 antibody (Abnova, H00003099-M01) was used in western blot on human samples (fig 3). Autophagy (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C64G5)
  • western blot; human; loading ...; fig 4j
Cell Signaling Technology Hk2 antibody (CST, 2867) was used in western blot on human samples (fig 4j). Sci Adv (2020) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; fig 2g
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples (fig 2g). Nature (2017) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; 1:1000; loading ...; fig 5c
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples at 1:1000 (fig 5c). J Clin Endocrinol Metab (2017) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; fig 5h
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples (fig 5h). Sci Rep (2017) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; mouse; loading ...; fig af6e
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on mouse samples (fig af6e). Mol Syst Biol (2017) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; loading ...; fig 3b
In order to explore the effect of different magnitudes of weight loss maintenance after intensive lifestyle interventions on cardiometabolic health, Cell Signaling Technology Hk2 antibody (Cell Signaling, C64G5) was used in western blot on human samples (fig 3b). Obes Res Clin Pract (2017) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; mouse; loading ...; fig 2b
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on mouse samples (fig 2b). Nat Immunol (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; mouse; loading ...; fig 4a
In order to test if LKB1 mutations contribute to cervical cancer initiation and progress, Cell Signaling Technology Hk2 antibody (Cell signaling, 2867) was used in western blot on mouse samples (fig 4a). Oncogene (2017) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; 1:1000; loading ...; fig s1
In order to evaluate the effects of pioglitazone on human Sertoli cells metabolism, Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples at 1:1000 (fig s1). Int J Biochem Cell Biol (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; loading ...; fig s9d
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867S) was used in western blot on human samples (fig s9d). Nature (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology Hk2 antibody (Cell Signaling, cs-2867) was used in western blot on mouse samples at 1:1000 (fig 5e). EMBO Mol Med (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; 1:5000; loading ...; fig 5a
In order to study 3-bromopyruvate, human colorectal cancer cells, glucose concentration, and hexokinase II expression, Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples at 1:5000 (fig 5a). Biosci Rep (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • immunohistochemistry; mouse; fig st1
  • western blot; mouse; fig st1
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in immunohistochemistry on mouse samples (fig st1) and in western blot on mouse samples (fig st1). Liver Int (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; 1:1000; fig 4
In order to investigate factors that control PHD1 activity, Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples at 1:1000 (fig 4). J Cell Sci (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • immunohistochemistry; mouse; 1:800; loading ...; fig 6a
In order to evaluate the use of phenformin with MLN0128 as a treatment strategy for non-small cell lung carcinoma, Cell Signaling Technology Hk2 antibody (Cell signaling, 2867) was used in immunohistochemistry on mouse samples at 1:800 (fig 6a). Cancer Res (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; 1:1000; fig 4b
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples at 1:1000 (fig 4b). Cell Death Dis (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; loading ...; fig 3c
In order to quantify proteins involved in mitochondrial oxidation and glucose and lipid metabolism in skeletal muscle of trained and untrained middle-aged men, Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples (fig 3c). Physiol Res (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; mouse; 1:1000; fig s9
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on mouse samples at 1:1000 (fig s9). Nat Commun (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human
Cell Signaling Technology Hk2 antibody (Cell Signaling Technology, 2867S) was used in western blot on human samples . J Physiol (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; mouse; 1:1000; fig 6l
Cell Signaling Technology Hk2 antibody (Cell Signaling Technology, 2867) was used in western blot on mouse samples at 1:1000 (fig 6l). FASEB J (2016) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; fig 5
Cell Signaling Technology Hk2 antibody (Cell signaling, 2867) was used in western blot on human samples (fig 5). J Cell Biol (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; fig 5a
In order to study the role of 14-3-3sigma in tumor metabolism, Cell Signaling Technology Hk2 antibody (Cell Signaling Technology, 2867) was used in western blot on human samples (fig 5a). Nat Commun (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; fig 6
In order to assess the effect of Roux-en-Y gastric bypass surgery on expression and regulation of proteins involved in regulation of peripheral glucose metabolism, Cell Signaling Technology Hk2 antibody (Cell Signaling Technology, 2867) was used in western blot on human samples (fig 6). Am J Physiol Regul Integr Comp Physiol (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human; 1:1000; loading ...; fig 1c
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on human samples at 1:1000 (fig 1c). Oncotarget (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • immunohistochemistry; mouse; 1:300; fig 8
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in immunohistochemistry on mouse samples at 1:300 (fig 8). J Clin Invest (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; human
In order to investigate the role of AMPK in regulating fatty acid oxidation in skeletal muscle with contraction/exercise, Cell Signaling Technology Hk2 antibody (Cell Signaling Technology, C64G5) was used in western blot on human samples . FASEB J (2015) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; rat
In order to study the effects of calorie restriction on glucose uptake and insulin signaling in muscle in vivo, Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in western blot on rat samples . PLoS ONE (2014) ncbi
domestic rabbit monoclonal (C64G5)
  • western blot; bovine; loading ...; fig 1d
Cell Signaling Technology Hk2 antibody (Cell Signaling, C64G5) was used in western blot on bovine samples (fig 1d). Oncogene (2014) ncbi
domestic rabbit monoclonal (C64G5)
  • immunocytochemistry; mouse
  • western blot; mouse
Cell Signaling Technology Hk2 antibody (Cell Signaling, 2867) was used in immunocytochemistry on mouse samples and in western blot on mouse samples . Exp Cell Res (2013) ncbi
Articles Reviewed
  1. Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
  2. Wiel C, Le Gal K, Ibrahim M, Jahangir C, Kashif M, Yao H, et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;: pubmed publisher
  3. Yu P, Wilhelm K, Dubrac A, Tung J, Alves T, Fang J, et al. FGF-dependent metabolic control of vascular development. Nature. 2017;545:224-228 pubmed publisher
  4. Krag T, Ruiz Ruiz C, Vissing J. Glycogen Synthesis in Glycogenin 1-Deficient Patients: A Role for Glycogenin 2 in Muscle. J Clin Endocrinol Metab. 2017;102:2690-2700 pubmed publisher
  5. Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, et al. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017;7:46344 pubmed publisher
  6. Graham N, Minasyan A, Lomova A, Cass A, Balanis N, Friedman M, et al. Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol. 2017;13:914 pubmed publisher
  7. Kudryavtseva A, Fedorova M, Zhavoronkov A, Moskalev A, Zasedatelev A, Dmitriev A, et al. Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells. BMC Genet. 2016;17:156 pubmed publisher
  8. Bramer S, Macedo A, Klein C. Hexokinase 2 drives glycogen accumulation in equine endometrium at day 12 of diestrus and pregnancy. Reprod Biol Endocrinol. 2017;15:4 pubmed publisher
  9. Dandanell S, Skovborg C, Præst C, Kristensen K, Nielsen M, Lionett S, et al. Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. Obes Res Clin Pract. 2017;11:489-498 pubmed publisher
  10. Gerriets V, Kishton R, Johnson M, Cohen S, Siska P, Nichols A, et al. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol. 2016;17:1459-1466 pubmed publisher
  11. Zeng Q, Chen J, Li Y, Werle K, Zhao R, Quan C, et al. LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism. Oncogene. 2017;36:1245-1255 pubmed publisher
  12. Meneses M, Bernardino R, Sa R, Silva J, Barros A, Sousa M, et al. Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis. Int J Biochem Cell Biol. 2016;79:52-60 pubmed publisher
  13. Powers J, Tsanov K, Pearson D, Roels F, Spina C, EBRIGHT R, et al. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016;535:246-51 pubmed publisher
  14. Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher
  15. Ho N, Morrison J, Silva A, Coomber B. The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. Biosci Rep. 2016;36:e00299 pubmed publisher
  16. Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed publisher
  17. Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
  18. Momcilovic M, McMickle R, Abt E, Seki A, Simko S, Magyar C, et al. Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Cancer Res. 2015;75:4910-22 pubmed publisher
  19. Carpentieri A, Cozzoli E, Scimeca M, Bonanno E, Sardanelli A, Gambacurta A. Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor. Cell Death Dis. 2015;6:e1974 pubmed publisher
  20. Vigelso A, Prats C, Ploug T, Dela F, Helge J. Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men. Physiol Res. 2016;65:293-302 pubmed
  21. Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed publisher
  22. Jacobs R, Lundby A, Fenk S, Gehrig S, Siebenmann C, Flück D, et al. Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle. J Physiol. 2016;594:1151-66 pubmed publisher
  23. Sharma B, Kolhe R, Black S, Keller J, Mivechi N, Satyanarayana A. Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J. 2016;30:262-75 pubmed publisher
  24. Xia H, Najafov A, Geng J, Galan Acosta L, Han X, Guo Y, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J Cell Biol. 2015;210:705-16 pubmed publisher
  25. Phan L, Chou P, Velazquez Torres G, Samudio I, Parreno K, Huang Y, et al. The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. Nat Commun. 2015;6:7530 pubmed publisher
  26. Albers P, Bojsen Møller K, Dirksen C, Serup A, Kristensen D, Frystyk J, et al. Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery. Am J Physiol Regul Integr Comp Physiol. 2015;309:R510-24 pubmed publisher
  27. Dai W, Wang F, Lu J, Xia Y, He L, Chen K, et al. By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. Oncotarget. 2015;6:13703-17 pubmed
  28. Venkatesh A, Ma S, Le Y, Hall M, Rüegg M, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015;125:1446-58 pubmed publisher
  29. Fentz J, Kjøbsted R, Birk J, Jordy A, Jeppesen J, Thorsen K, et al. AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice. FASEB J. 2015;29:1725-38 pubmed publisher
  30. Desideri E, Vegliante R, Cardaci S, Nepravishta R, Paci M, Ciriolo M. MAPK14/p38?-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation. Autophagy. 2014;10:1652-65 pubmed publisher
  31. Sharma N, Sequea D, Castorena C, Arias E, Qi N, Cartee G. Heterogeneous effects of calorie restriction on in vivo glucose uptake and insulin signaling of individual rat skeletal muscles. PLoS ONE. 2014;8:e65118 pubmed publisher
  32. Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman J. Theileria induces oxidative stress and HIF1? activation that are essential for host leukocyte transformation. Oncogene. 2014;33:1809-17 pubmed publisher
  33. Mathew J, Loranger A, Gilbert S, Faure R, Marceau N. Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling. Exp Cell Res. 2013;319:474-86 pubmed publisher