This is a Validated Antibody Database (VAD) review about rat Gclm, based on 11 published articles (read how Labome selects the articles), using Gclm antibody in all methods. It is aimed to help Labome visitors find the most suited Gclm antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Gclm synonym: Glclr; glutamate--cysteine ligase regulatory subunit; GCS light chain; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory

Abcam
rabbit monoclonal (EPR6668)
  • other; human; loading ...; fig 4c
Abcam Gclm antibody (Abcam, ab124827) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit monoclonal (EPR6668)
  • immunohistochemistry - paraffin section; human; loading ...; fig 5c
  • western blot; human; 1:100; loading ...; fig 5a
Abcam Gclm antibody (Abcam, ab124827) was used in immunohistochemistry - paraffin section on human samples (fig 5c) and in western blot on human samples at 1:100 (fig 5a). Biochim Biophys Acta (2017) ncbi
rabbit polyclonal
  • western blot; mouse; fig 6
Abcam Gclm antibody (Abcam, ab81445) was used in western blot on mouse samples (fig 6). Redox Biol (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 2d
Abcam Gclm antibody (Abcam, ab153967) was used in western blot on mouse samples at 1:500 (fig 2d). Toxicol Appl Pharmacol (2016) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam Gclm antibody (Abcam, ab81445) was used in western blot on mouse samples . Arthritis Rheumatol (2014) ncbi
rabbit polyclonal
  • western blot; rat
Abcam Gclm antibody (Abcam, ab81445) was used in western blot on rat samples . J Gerontol A Biol Sci Med Sci (2014) ncbi
rabbit polyclonal
  • western blot; mouse
In order to study the ability of moderate exercise to reverse the age-related decline in cardiac Nrf2 transcriptional activity and its associated antioxidants, Abcam Gclm antibody (Abcam, ab81445) was used in western blot on mouse samples . PLoS ONE (2012) ncbi
Proteintech Group
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3c
Proteintech Group Gclm antibody (Proteintech Group, 14241-1-AP) was used in western blot on mouse samples (fig 3c). Neuroscience (2018) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 1
Proteintech Group Gclm antibody (Proteintech, 14241-1-AP) was used in western blot on human samples at 1:1000 (fig 1). J Hematol Oncol (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (F-8)
  • western blot; human; 1:500; fig 5
Santa Cruz Biotechnology Gclm antibody (Santa Cruz, sc166603) was used in western blot on human samples at 1:500 (fig 5). Biochem Pharmacol (2016) ncbi
mouse monoclonal (E-4)
  • western blot; rat
Santa Cruz Biotechnology Gclm antibody (Santa Cruz Biotechnology, sc-55586) was used in western blot on rat samples . Chem Biol Interact (2009) ncbi
Articles Reviewed
  1. Lv W, Deng B, Duan W, Li Y, Liu Y, Li Z, et al. Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury. Neuroscience. 2018;382:1-13 pubmed publisher
  2. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  3. Jin X, Xu Z, Cao J, Shao P, Zhou M, Qin Z, et al. Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia. Biochim Biophys Acta. 2017;1865:1207-1214 pubmed publisher
  4. Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, et al. Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer. J Hematol Oncol. 2016;9:83 pubmed publisher
  5. Shanmugam G, Narasimhan M, Sakthivel R, Kumar R R, Davidson C, Palaniappan S, et al. A biphasic effect of TNF-? in regulation of the Keap1/Nrf2 pathway in cardiomyocytes. Redox Biol. 2016;9:77-89 pubmed publisher
  6. Wang Y, Chen M, Zhang Y, Huo T, Fang Y, Jiao X, et al. Effects of realgar on GSH synthesis in the mouse hippocampus: Involvement of system XAG(-), system XC(-), MRP-1 and Nrf2. Toxicol Appl Pharmacol. 2016;308:91-101 pubmed publisher
  7. Koyani C, Kitz K, Rossmann C, Bernhart E, Huber E, Trummer C, et al. Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. Biochem Pharmacol. 2016;104:29-41 pubmed publisher
  8. Wu T, Ye Y, Min S, Zhu J, Khobahy E, Zhou J, et al. Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid. Arthritis Rheumatol. 2014;66:3129-39 pubmed publisher
  9. Mach J, Huizer Pajkos A, Cogger V, McKenzie C, Le Couteur D, Jones B, et al. The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. J Gerontol A Biol Sci Med Sci. 2014;69:387-97 pubmed publisher
  10. Gounder S, Kannan S, Devadoss D, Miller C, Whitehead K, Whitehead K, et al. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS ONE. 2012;7:e45697 pubmed publisher
  11. Paonessa J, Munday C, Mhawech Fauceglia P, Munday R, Zhang Y. 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder. Chem Biol Interact. 2009;180:119-26 pubmed publisher