This is a Validated Antibody Database (VAD) review about rat Fyn, based on 32 published articles (read how Labome selects the articles), using Fyn antibody in all methods. It is aimed to help Labome visitors find the most suited Fyn antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Santa Cruz Biotechnology
mouse monoclonal (15)
  • western blot; mouse; 1:1000; loading ...; fig 4b
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-434) was used in western blot on mouse samples at 1:1000 (fig 4b). Cell Rep Med (2022) ncbi
mouse monoclonal (15)
  • western blot; mouse; 1:200; loading ...; fig 4g
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-434) was used in western blot on mouse samples at 1:200 (fig 4g). Front Pharmacol (2020) ncbi
mouse monoclonal (E-3)
  • western blot; human; loading ...; fig 3c
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, SC-365913) was used in western blot on human samples (fig 3c). Redox Biol (2017) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:1000; loading ...; fig s9b
In order to examine whether p140Cap protein levels in ERBB2-amplified breast cancer patients correlate with survival, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, B-12) was used in western blot on human samples at 1:1000 (fig s9b). Nat Commun (2017) ncbi
mouse monoclonal
  • western blot; human; 1:1000; loading ...; fig s9b
In order to examine whether p140Cap protein levels in ERBB2-amplified breast cancer patients correlate with survival, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, B-12) was used in western blot on human samples at 1:1000 (fig s9b). Nat Commun (2017) ncbi
mouse monoclonal (E-12)
  • western blot; human; fig s17b
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-271294) was used in western blot on human samples (fig s17b). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (B-12)
  • western blot; rat; loading ...
In order to examine the impact of ischemia/reperfusion injury on sodium potassium ATPase enzymatic and signaling functions, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, Sc-8056) was used in western blot on rat samples . Physiol Rep (2016) ncbi
mouse monoclonal (E-3)
  • western blot; human; loading ...; fig 4c
In order to characterize the molecular changes involved in human aortic smooth muscle cell proliferation, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, SC-365913) was used in western blot on human samples (fig 4c). Sci Rep (2016) ncbi
mouse monoclonal (B-12)
  • western blot; human; fig 2
In order to determine an enrichment in insulin-like growth factor I receptor, c-Src, G-protein-coupled receptor kinases, and focal adhesion kinase in porstate cancer cell exosomes, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in western blot on human samples (fig 2). J Cell Biochem (2017) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • immunoprecipitation; human; 1:50; fig 4
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:200; fig 1
In order to study improvement of the pathology of hypertrophic scar by simultaneous deactivation of FAK and Src, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1), in immunoprecipitation on human samples at 1:50 (fig 4), in immunocytochemistry on human samples at 1:100 (fig 4) and in western blot on human samples at 1:200 (fig 1). Sci Rep (2016) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:200; fig 1
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056;) was used in western blot on human samples at 1:200 (fig 1). Int J Mol Med (2016) ncbi
mouse monoclonal (B-12)
  • western blot; rat; loading ...; fig 8a
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in western blot on rat samples (fig 8a). J Cell Mol Med (2016) ncbi
mouse monoclonal (15)
  • western blot; rat
In order to study how BDNF activation and phosphorylation of Fyn regulate oligodendrocyte myelination, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotech, sc-434) was used in western blot on rat samples . Glia (2016) ncbi
mouse monoclonal (B-12)
  • immunocytochemistry; mouse
In order to investigate the molecular mechanisms involved in TASK1 internalization in PC12 cells, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in immunocytochemistry on mouse samples . Am J Physiol Cell Physiol (2015) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in western blot on human samples . Mol Cell Endocrinol (2015) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:1000; fig 5
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056 B-12) was used in western blot on human samples at 1:1000 (fig 5). PLoS ONE (2015) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:50
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in immunohistochemistry - paraffin section on human samples at 1:50. Exp Dermatol (2015) ncbi
mouse monoclonal (B-12)
  • immunocytochemistry; human; 1:50
  • western blot; human; 1:200
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, Sc-8056) was used in immunocytochemistry on human samples at 1:50 and in western blot on human samples at 1:200. Cell Signal (2015) ncbi
mouse monoclonal (B-12)
  • western blot; mouse; fig 8
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on mouse samples (fig 8). J Neurosci (2015) ncbi
mouse monoclonal (B-12)
  • western blot; pigs
In order to study the effect of ouabain on Src kinase and Na(+)/K(+)-ATPase, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on pigs samples . Biochem Biophys Res Commun (2014) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:150
  • immunoprecipitation; human
  • western blot; human; 1:1000
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in immunohistochemistry - paraffin section on human samples at 1:150, in immunoprecipitation on human samples and in western blot on human samples at 1:1000. Int J Cancer (2014) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on human samples . Eur J Cancer (2014) ncbi
mouse monoclonal (B-12)
  • western blot; mouse
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in western blot on mouse samples . J Hepatol (2014) ncbi
mouse monoclonal (15)
  • immunoprecipitation; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-434) was used in immunoprecipitation on human samples . J Biol Chem (2013) ncbi
Abcam
domestic rabbit monoclonal (EPR5500)
  • western blot; mouse; 1:3000; loading ...; fig 3e
Abcam Fyn antibody (Abcam, ab125016) was used in western blot on mouse samples at 1:3000 (fig 3e). Front Aging Neurosci (2019) ncbi
domestic rabbit monoclonal (EPR5500)
  • western blot; rat
In order to determine the role of miR-125a-3p and Fyn in granulosa cells, Abcam Fyn antibody (Abcam, ab125016) was used in western blot on rat samples . FASEB J (2015) ncbi
BD Biosciences
mouse monoclonal (25/Fyn)
  • western blot; dogs; loading ...; fig s4f
BD Biosciences Fyn antibody (BD Biosciences, 610163) was used in western blot on dogs samples (fig s4f). Life Sci Alliance (2021) ncbi
mouse monoclonal (25/Fyn)
  • western blot; human; loading ...; fig 2e
BD Biosciences Fyn antibody (BD Biosciences, clone 25/Fyn) was used in western blot on human samples (fig 2e). Biol Open (2019) ncbi
mouse monoclonal (25/Fyn)
  • immunohistochemistry - frozen section; rat; loading ...; fig 6h
  • western blot; rat; loading ...; fig 6i
BD Biosciences Fyn antibody (Becton-Dickinson, 610163) was used in immunohistochemistry - frozen section on rat samples (fig 6h) and in western blot on rat samples (fig 6i). Development (2017) ncbi
mouse monoclonal (25/Fyn)
  • immunocytochemistry; rat; 1:500; fig 7
  • western blot; rat; 1:250; fig 5
In order to study how cellular localization affects DHHC5 activity, BD Biosciences Fyn antibody (BD Transduction Laboratories, 610163) was used in immunocytochemistry on rat samples at 1:500 (fig 7) and in western blot on rat samples at 1:250 (fig 5). Nat Commun (2015) ncbi
mouse monoclonal (25/Fyn)
  • western blot; mouse
BD Biosciences Fyn antibody (Transduction Laboratories, 25) was used in western blot on mouse samples . Eur J Immunol (2015) ncbi
mouse monoclonal (25/Fyn)
  • western blot; human; fig 7
BD Biosciences Fyn antibody (BD, 610163) was used in western blot on human samples (fig 7). J Biol Chem (2014) ncbi
mouse monoclonal (25/Fyn)
  • western blot; mouse
In order to study the regulation of adipogenesis by mechanical strain in mesenchymal stem cells and the roles played by Fyn, mTORC2 and RhoA, BD Biosciences Fyn antibody (BD Biosciences, 610163) was used in western blot on mouse samples . Stem Cells (2013) ncbi
Articles Reviewed
  1. Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, et al. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022;3:100597 pubmed publisher
  2. Kajiwara K, Yamano S, Aoki K, Okuzaki D, Matsumoto K, Okada M. CDCP1 promotes compensatory renal growth by integrating Src and Met signaling. Life Sci Alliance. 2021;4: pubmed publisher
  3. Tan Y, Xu Y, Cheng C, Zheng C, Zeng W, Wang J, et al. LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. Front Pharmacol. 2020;11:183 pubmed publisher
  4. Yao X, Xian X, Fang M, Fan S, Li W. Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer's Disease Mice. Front Aging Neurosci. 2019;11:365 pubmed publisher
  5. Xiong X, Lee C, Li W, Yu J, Zhu L, Kim Y, et al. Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins. Biol Open. 2019;: pubmed publisher
  6. Roberts S, Dun X, Doddrell R, Mindos T, Drake L, Onaitis M, et al. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development. 2017;144:3114-3125 pubmed publisher
  7. Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed publisher
  8. Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed publisher
  9. Sanchez Martin M, Ambesi Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, et al. Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proc Natl Acad Sci U S A. 2017;114:2006-2011 pubmed publisher
  10. Belliard A, Gulati G, Duan Q, Alves R, Brewer S, Madan N, et al. Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning. Physiol Rep. 2016;4: pubmed
  11. Janjanam J, Rao G. Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1. Sci Rep. 2016;6:28687 pubmed publisher
  12. DeRita R, Zerlanko B, Singh A, Lu H, Iozzo R, Benovic J, et al. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017;118:66-73 pubmed publisher
  13. Su L, Li X, Wu X, Hui B, Han S, Gao J, et al. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Sci Rep. 2016;6:26023 pubmed publisher
  14. Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed publisher
  15. Peng K, Tian X, Qian Y, Skibba M, Zou C, Liu Z, et al. Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II. J Cell Mol Med. 2016;20:482-94 pubmed publisher
  16. Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick T, et al. Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia. 2016;64:255-69 pubmed publisher
  17. Brigidi G, Santyr B, Shimell J, Jovellar B, Bamji S. Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Nat Commun. 2015;6:8200 pubmed publisher
  18. Matsuoka H, Inoue M. Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor. Am J Physiol Cell Physiol. 2015;309:C251-63 pubmed publisher
  19. Grossman H, Chuderland D, Ninio Many L, Hasky N, Kaplan Kraicer R, Shalgi R. A novel regulatory pathway in granulosa cells, the LH/human chorionic gonadotropin-microRNA-125a-3p-Fyn pathway, is required for ovulation. FASEB J. 2015;29:3206-16 pubmed publisher
  20. Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  21. Carnesecchi J, Malbouyres M, de Mets R, Balland M, Beauchef G, Vié K, et al. Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS ONE. 2015;10:e0120672 pubmed publisher
  22. Choi C, Kim Y, Sohn J, Lee H, Kim W. Focal adhesion kinase and Src expression in premalignant and malignant skin lesions. Exp Dermatol. 2015;24:361-4 pubmed publisher
  23. Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed publisher
  24. Sheng L, Leshchyns ka I, Sytnyk V. Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. J Neurosci. 2015;35:1739-52 pubmed publisher
  25. Gütgemann S, Sandusky M, Wingert S, Claus M, Watzl C. Recruitment of activating NK-cell receptors 2B4 and NKG2D to membrane microdomains in mammalian cells is dependent on their transmembrane regions. Eur J Immunol. 2015;45:1258-69 pubmed publisher
  26. Gable M, Abdallah S, Najjar S, Liu L, Askari A. Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase. Biochem Biophys Res Commun. 2014;446:1151-4 pubmed publisher
  27. Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, et al. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 2014;289:12313-29 pubmed publisher
  28. Bouchekioua Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedER? is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher
  29. Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X, et al. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. 2014;50:1013-24 pubmed publisher
  30. Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  31. Thompson W, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, et al. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013;31:2528-37 pubmed publisher
  32. Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher