This is a Validated Antibody Database (VAD) review about rat Cdkn2a, based on 27 published articles (read how Labome selects the articles), using Cdkn2a antibody in all methods. It is aimed to help Labome visitors find the most suited Cdkn2a antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Cdkn2a synonym: Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF

Abcam
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4c
Abcam Cdkn2a antibody (Abcam, ab189034) was used in western blot on mouse samples (fig 4c). Aging Cell (2021) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 1a
Abcam Cdkn2a antibody (Abcam, ab54210) was used in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 1a). Aging (Albany NY) (2021) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry; human; 1:1000
Abcam Cdkn2a antibody (Abcam, 2D9A12) was used in immunohistochemistry on human samples at 1:1000. Ann Med (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4a
Abcam Cdkn2a antibody (Abcam, ab189034) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 4a). Cell Death Dis (2020) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry; human; 1:500; loading ...; fig 1a
Abcam Cdkn2a antibody (Abcam, ab54210) was used in immunohistochemistry on human samples at 1:500 (fig 1a). elife (2020) ncbi
mouse monoclonal (2D9A12)
  • western blot; human; loading ...; fig 5d
Abcam Cdkn2a antibody (Santa Cruz, ab54210) was used in western blot on human samples (fig 5d). elife (2020) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry - free floating section; mouse; 1:100; loading ...; fig 4d
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1c
Abcam Cdkn2a antibody (Abcam, ab54210) was used in immunohistochemistry - free floating section on mouse samples at 1:100 (fig 4d) and in immunohistochemistry - paraffin section on human samples at 1:100 (fig 1c). Nat Neurosci (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4c
Abcam Cdkn2a antibody (Abcam, ab189034) was used in immunohistochemistry on mouse samples at 1:500 (fig 4c). Cell Death Dis (2018) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3i
In order to elucidate novel functions of the senescence-associated secretory in promoting a proregenerative response through the induction of cell plasticity and stemness, Abcam Cdkn2a antibody (Abcam, 2D9A12) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig 3i). Genes Dev (2017) ncbi
mouse monoclonal (2D9A12)
  • western blot; human; loading ...; fig 8a
Abcam Cdkn2a antibody (Abcam, ab54210) was used in western blot on human samples (fig 8a). J Cell Physiol (2017) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig s5
In order to discover a role for H3K27 methylation in governing chondrocyte proliferation and hypertrophy in the growth plate, Abcam Cdkn2a antibody (abcam, ab54210) was used in immunohistochemistry - paraffin section on mouse samples at 1:1000 (fig s5). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s6
In order to discover a role for H3K27 methylation in governing chondrocyte proliferation and hypertrophy in the growth plate, Abcam Cdkn2a antibody (abcam, ab189034) was used in western blot on mouse samples at 1:1000 (fig s6). Nat Commun (2016) ncbi
mouse monoclonal (2D9A12)
  • western blot; human; loading ...; fig 1b
Abcam Cdkn2a antibody (Abcam, ab54210) was used in western blot on human samples (fig 1b). Oncotarget (2016) ncbi
mouse monoclonal (2D9A12)
  • western blot; mouse; fig 4
Abcam Cdkn2a antibody (Abcam, ab54210) was used in western blot on mouse samples (fig 4). Autophagy (2015) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry - paraffin section; human
In order to study the clinical and pathological findings of two unusual cases of Bowen's disease, Abcam Cdkn2a antibody (Abcam, 2D9A12) was used in immunohistochemistry - paraffin section on human samples . J Dermatol (2015) ncbi
mouse monoclonal (2D9A12)
  • western blot; human; fig 7
Abcam Cdkn2a antibody (Abcam, ab54210) was used in western blot on human samples (fig 7). Oncogene (2015) ncbi
mouse monoclonal (2D9A12)
  • immunohistochemistry - paraffin section; human; 1:200; fig 3
  • western blot; human; 1:1000; fig 1
Abcam Cdkn2a antibody (Abcam, ab54210) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 3) and in western blot on human samples at 1:1000 (fig 1). Arthritis Res Ther (2014) ncbi
mouse monoclonal (2D9A12)
  • western blot; human
Abcam Cdkn2a antibody (Abcam, ab54210) was used in western blot on human samples . Age (Dordr) (2013) ncbi
Invitrogen
mouse monoclonal (1E12E10)
  • immunohistochemistry; mouse; loading ...; fig 5b
Invitrogen Cdkn2a antibody (Invitrogen, MA5-17142) was used in immunohistochemistry on mouse samples (fig 5b). Exp Mol Med (2021) ncbi
rat monoclonal (12-A1-1)
  • immunohistochemistry; mouse; fig 1
  • western blot; mouse; fig 1
In order to analyze the induction of tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo due to loss of keratin 17, Invitrogen Cdkn2a antibody (Thermo Scientific, MA1-16664) was used in immunohistochemistry on mouse samples (fig 1) and in western blot on mouse samples (fig 1). Oncogene (2016) ncbi
domestic rabbit polyclonal
In order to use transgenic mice to show that CDK5 activity is crucial for cell cycle progression and medullary thyroid carcinoma proliferation, Invitrogen Cdkn2a antibody (Pierce, PA5-20379) was used . Oncotarget (2015) ncbi
domestic rabbit polyclonal
In order to elucidate how GREM1 contributes to hereditary mixed polyposis syndrome, Invitrogen Cdkn2a antibody (Thermoscientific, PA1-30670) was used . Nat Med (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (C-7)
  • western blot; rat; loading ...; fig 5a
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology, sc-377412) was used in western blot on rat samples (fig 5a). Mol Med Rep (2020) ncbi
mouse monoclonal (C-7)
  • western blot; mouse; loading ...; fig 2j
Santa Cruz Biotechnology Cdkn2a antibody (Santa, sc-377412) was used in western blot on mouse samples (fig 2j). Aging Cell (2019) ncbi
mouse monoclonal (C-7)
  • western blot; mouse; fig s2
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz, sc-377412) was used in western blot on mouse samples (fig s2). Sci Rep (2016) ncbi
mouse monoclonal (C-7)
  • western blot; human; 1:500; fig 2
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz, sc-377412) was used in western blot on human samples at 1:500 (fig 2). Nat Commun (2015) ncbi
Novus Biologicals
domestic rabbit polyclonal (KBB36)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1g
Novus Biologicals Cdkn2a antibody (Novus, NB200-106) was used in immunohistochemistry on mouse samples at 1:100 (fig 1g). Nat Commun (2021) ncbi
domestic rabbit polyclonal (KBB36)
  • immunohistochemistry; mouse; loading ...; fig s4c
In order to find a role for chicken ovalbumin upstream promoter-transcription factor II in a murine model of duchenne muscular dystrophy, Novus Biologicals Cdkn2a antibody (Novus Biologicals, NB200-106) was used in immunohistochemistry on mouse samples (fig s4c). J Clin Invest (2016) ncbi
Articles Reviewed
  1. Novais E, Tran V, Johnston S, Darris K, Roupas A, Sessions G, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213 pubmed publisher
  2. Lee H, Donati A, Feliers D, Sun Y, Ding Y, Madesh M, et al. Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging Cell. 2021;20:e13407 pubmed publisher
  3. Huang P, Bai L, Liu L, Fu J, Wu K, Liu H, et al. Redd1 knockdown prevents doxorubicin-induced cardiac senescence. Aging (Albany NY). 2021;13:13788-13806 pubmed publisher
  4. Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed publisher
  5. Azzimonti B, Raimondo L, Squarzanti D, Rosso T, Zanetta P, Aluffi Valletti P, et al. Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma. Ann Med. 2021;53:541-550 pubmed publisher
  6. Liang X, Yan Z, Ma W, Qian Y, Zou X, Cui Y, et al. Peroxiredoxin 4 protects against ovarian ageing by ameliorating D-galactose-induced oxidative damage in mice. Cell Death Dis. 2020;11:1053 pubmed publisher
  7. Cherif H, Bisson D, Mannarino M, Rabau O, Ouellet J, Haglund L. Senotherapeutic drugs for human intervertebral disc degeneration and low back pain. elife. 2020;9: pubmed publisher
  8. Hu D, Dong R, Zhang Y, Yang Y, Chen Z, Tang Y, et al. Age‑related changes in mineralocorticoid receptors in rat hearts. Mol Med Rep. 2020;22:1859-1867 pubmed publisher
  9. Alessio N, Squillaro T, Di Bernardo G, Galano G, De Rosa R, Melone M, et al. Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. elife. 2020;9: pubmed publisher
  10. Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler R, Zhang S, et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22:719-728 pubmed publisher
  11. Chen L, Yang R, Qiao W, Zhang W, Chen J, Mao L, et al. 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling. Aging Cell. 2019;18:e12951 pubmed publisher
  12. Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, et al. Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis. 2018;9:105 pubmed publisher
  13. Ritschka B, Storer M, Mas A, Heinzmann F, Ortells M, Morton J, et al. The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes Dev. 2017;31:172-183 pubmed publisher
  14. Squillaro T, Antonucci I, Alessio N, Esposito A, Cipollaro M, Melone M, et al. Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. J Cell Physiol. 2017;232:3454-3467 pubmed publisher
  15. Lui J, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, et al. EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Nat Commun. 2016;7:13685 pubmed publisher
  16. Saia M, Termanini A, Rizzi N, Mazza M, Barbieri E, Valli D, et al. AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells. Sci Rep. 2016;6:34957 pubmed publisher
  17. Xie X, Tsai S, Tsai M. COUP-TFII regulates satellite cell function and muscular dystrophy. J Clin Invest. 2016;126:3929-3941 pubmed publisher
  18. Mirkheshti N, Park S, Jiang S, Cropper J, Werner S, Song C, et al. Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer. Oncotarget. 2016;7:62240-62254 pubmed publisher
  19. Hobbs R, Batazzi A, Han M, Coulombe P. Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo. Oncogene. 2016;35:5653-5662 pubmed publisher
  20. Grootaert M, da Costa Martins P, Bitsch N, Pintelon I, De Meyer G, Martinet W, et al. Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. Autophagy. 2015;11:2014-2032 pubmed publisher
  21. Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, et al. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 2015;6:7505 pubmed publisher
  22. Pozo K, Hillmann A, Augustyn A, Plattner F, Hai T, Singh T, et al. Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis. Oncotarget. 2015;6:12080-93 pubmed
  23. Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med. 2015;21:62-70 pubmed publisher
  24. Hsu C, Chen Y, Yang W, Hsu K, Chao S, Lee J. Bowen's disease with features resembling myrmecia wart. J Dermatol. 2015;42:90-3 pubmed publisher
  25. Wang W, Catto J, Meuth M. Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors. Oncogene. 2015;34:2887-96 pubmed publisher
  26. Philipot D, Guérit D, Platano D, Chuchana P, Olivotto E, Espinoza F, et al. p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis. Arthritis Res Ther. 2014;16:R58 pubmed publisher
  27. Zhang B, Cui S, Bai X, Zhuo L, Sun X, Hong Q, et al. SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr). 2013;35:2237-53 pubmed publisher