This is a Validated Antibody Database (VAD) review about rat Cblb, based on 11 published articles (read how Labome selects the articles), using Cblb antibody in all methods. It is aimed to help Labome visitors find the most suited Cblb antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Cblb synonym: E3 ubiquitin-protein ligase CBL-B; Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; casitas B-lineage lymphoma proto-oncogene b; signal transduction protein CBL-B

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (B-5)
  • western blot knockout validation; mouse; fig 6
Santa Cruz Biotechnology Cblb antibody (santa Cruz, sc-376409) was used in western blot knockout validation on mouse samples (fig 6). Mol Syst Biol (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (D3C12)
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology Cblb antibody (Cell Signaling, D3C12) was used in western blot knockout validation on mouse samples (fig 1). Oncotarget (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (G-1)
  • western blot; mouse; loading ...; fig 6c
Santa Cruz Biotechnology Cblb antibody (Santa, SC-8006) was used in western blot on mouse samples (fig 6c). Sci Signal (2018) ncbi
mouse monoclonal (B-5)
  • western blot knockout validation; mouse; fig 6
Santa Cruz Biotechnology Cblb antibody (santa Cruz, sc-376409) was used in western blot knockout validation on mouse samples (fig 6). Mol Syst Biol (2016) ncbi
mouse monoclonal (G-1)
  • immunoprecipitation; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 6c
Santa Cruz Biotechnology Cblb antibody (SantaCruz, G-1) was used in immunoprecipitation on mouse samples (fig 2a) and in western blot on mouse samples (fig 6c). Nat Med (2016) ncbi
mouse monoclonal (G-1)
  • western blot; human; loading ...; fig 6b
In order to establish an integrated multilayered proteomics approach to study receptor signaling, Santa Cruz Biotechnology Cblb antibody (SantaCruz, sc-8006) was used in western blot on human samples (fig 6b). Nat Struct Mol Biol (2016) ncbi
mouse monoclonal (G-1)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, Santa Cruz Biotechnology Cblb antibody (SCBT, G-1) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (G-1)
  • western blot; human; fig 1e
In order to characterize enhancement of tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b by H19 non coding RNA-derived miR-675, Santa Cruz Biotechnology Cblb antibody (Santa Cruz, sc-8006) was used in western blot on human samples (fig 1e). Oncotarget (2015) ncbi
mouse monoclonal (G-1)
  • flow cytometry; human
In order to study the molecular signaling responsible for retinoic acid-induced differentiation, Santa Cruz Biotechnology Cblb antibody (Santa Cruz Biotechnology, sc-8006) was used in flow cytometry on human samples . PLoS ONE (2015) ncbi
mouse monoclonal (B-5)
  • immunohistochemistry - paraffin section; human; 1:250; fig 2
Santa Cruz Biotechnology Cblb antibody (santa Cruz, sc-376409) was used in immunohistochemistry - paraffin section on human samples at 1:250 (fig 2). Oncotarget (2015) ncbi
Cell Signaling Technology
rabbit monoclonal (D3C12)
  • western blot; human; fig 8c
Cell Signaling Technology Cblb antibody (Cell Signaling, 9498S) was used in western blot on human samples (fig 8c). Cancer Cell (2017) ncbi
rabbit monoclonal (D3C12)
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology Cblb antibody (Cell Signaling, D3C12) was used in western blot knockout validation on mouse samples (fig 1). Oncotarget (2016) ncbi
rabbit monoclonal (D3C12)
  • western blot; human; loading ...; fig 7
Cell Signaling Technology Cblb antibody (Cell Signaling, 9498) was used in western blot on human samples (fig 7). J Biol Chem (2016) ncbi
rabbit monoclonal (D3C12)
  • western blot; human
In order to study the molecular signaling responsible for retinoic acid-induced differentiation, Cell Signaling Technology Cblb antibody (Cell Signaling, 9498) was used in western blot on human samples . PLoS ONE (2015) ncbi
Articles Reviewed
  1. Roy N, MacKay J, Robertson T, Hammer D, Burkhardt J. Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Sci Signal. 2018;11: pubmed publisher
  2. Robles Valero J, Lorenzo Martín L, Menacho Márquez M, Fernández Pisonero I, Abad A, Camos M, et al. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2017;32:608-623.e9 pubmed publisher
  3. Voisinne G, García Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, et al. Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation. Mol Syst Biol. 2016;12:876 pubmed publisher
  4. Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, et al. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med. 2016;22:906-14 pubmed publisher
  5. Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck M, et al. A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Oncotarget. 2016;7:51107-51123 pubmed publisher
  6. Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher
  7. Rorsman C, Tsioumpekou M, Heldin C, Lennartsson J. The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem. 2016;291:11608-18 pubmed publisher
  8. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  9. Vennin C, Spruyt N, Dahmani F, Julien S, Bertucci F, Finetti P, et al. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. Oncotarget. 2015;6:29209-23 pubmed publisher
  10. Bunaciu R, Jensen H, Macdonald R, Latocha D, Varner J, Yen A. 6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. PLoS ONE. 2015;10:e0135668 pubmed publisher
  11. Zhang L, Teng Y, Fan Y, Wang Y, Li W, Shi J, et al. The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis. Oncotarget. 2015;6:22918-33 pubmed